Inhibition of Migration of Normal Guinea Pig Blood Leukocytes by Homologous Immune γ&lt;sub&gt;2&lt;/sub&gt;-Globulin in the Presence of Specific Antigen

Packalén, Thorolf; Wasserman, J

doi:10.1159/000230569

Cited by 21 publications

(5 citation statements)

References 2 publications

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“…Migration inhibition testing was first described for inhibition of macrophage migration (David et al, 1964), and has been well correlated with delayed hypersensitivity and thus cell-mediated immune mechanisms. We have previously reviewed the various migration inhibition tests used in autoimmune thyroid disease (Okita et af., 1980a) and have indicated that tests using T lymphocytes alone are not subject to the criticisms levelled at the direct leukocyte inhibition factor test, of B lymphocyte (Rocklin et af., 1974;Yoshida et al, 1973) or immune complex (Packalen & Wasserman, 1971;Kotkes & Pick, 1974;Hall, 1978) involvement.…”

Section: Discussionmentioning

confidence: 99%

Allosuppressor T Lymphocytes Abolish Migration Inhibition Factor Production in Autoimmune Thyroid Disease: Evidence From Radiosensitivity Experiments

Topliss

Okita

Lewis

et al. 1981

Clinical Endocrinology

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The ability of normal T lymphocytes to abolish the production of migration inhibition factor by antigen-sensitized T lymphocytes of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in response to thyroid antigen has been studied by a modified migration inhibition factor test using isolated T lymphocytes alone. The production of migration inhibition factor was consistently abolished when normal T lymphocytes were mixed with GD or HT T lymphocytes in various ratios (1:9, 2:8, 5:5) as reported previously (Okita et al. 1980b). However, prior in-vitro irradiation (1000 rad) of the normal T lymphocytes resulted in loss of their ability to abolish migration inhibition factor production by the antigen-sensitized T lymphocytes of GD and HT. The effect is consistent with the radiosensitivity of suppressor T lymphocytes and indicates that the effect of normal T lymphocytes on GD and HT T lymphocytes is one of allosuppression. The results support the view that there is a defect in suppressor T cell function in GD and HT.

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Section: Discussionmentioning

confidence: 99%

Allosuppressor T Lymphocytes Abolish Migration Inhibition Factor Production in Autoimmune Thyroid Disease: Evidence From Radiosensitivity Experiments

Topliss

Okita

Lewis

et al. 1981

Clinical Endocrinology

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“…It is well known that measles virus induces dam age to the nuclear chromosomes [18] and this could interfere with migration inhibi tion factor release. The migration inhibition could also be mediated by antigen-antibody complexes [19,20].…”

Section: Discussionmentioning

confidence: 99%

Cell-Mediated Immunity in Measles Using the Leucocyte Migration Test

Desai¹,

Strashoon²,

Wesley³

1978

Int Arch Allergy Immunol

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The cell-mediated immune response was investigated in 21 children with acute measles and in 8 healthy children using the intradermal Heaf and leucocyte migration tests. Tuberculin and purified protein derivative were used as antigens. Whereas all the children with measles were anergic in the in vivo test, two groups of children, i. e. ‘reactors’ and ‘non-reactors’ could be delineated with the in vitro test. The mechanisms responsible for the anergy are discussed.

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“…It has been demonstrated that homologous IgG (y-subclass) may cause leucocyte inhibition in the presence of specific antigen (17). This observation leads us to the question of the immunological significance of the method.…”

Section: Qmentioning

confidence: 99%

Inhibition of Leucocyte Migration in Man by the Agarose Plate Technique Using Protein Purified Derivatives (Ppd) From Three Different Sources

Passaleva

Forti

Ricci

1974

Allergy

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Inhibition of Migration of Normal Guinea Pig Blood Leukocytes by Homologous Immune γ<sub>2</sub>-Globulin in the Presence of Specific Antigen

Cited by 21 publications

References 2 publications

Allosuppressor T Lymphocytes Abolish Migration Inhibition Factor Production in Autoimmune Thyroid Disease: Evidence From Radiosensitivity Experiments

Allosuppressor T Lymphocytes Abolish Migration Inhibition Factor Production in Autoimmune Thyroid Disease: Evidence From Radiosensitivity Experiments

Cell-Mediated Immunity in Measles Using the Leucocyte Migration Test

Inhibition of Leucocyte Migration in Man by the Agarose Plate Technique Using Protein Purified Derivatives (Ppd) From Three Different Sources

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