Inhibition of microtubule assembly and cytotoxic effect of graphene oxide on human colorectal carcinoma cell HCT116

Bera, Supriyo; Ghosh, Suvranil; Ali, Asif; Pal, Mahadeb; Chakrabarti, Pinak

doi:10.1016/j.abb.2021.108940

Cited by 13 publications

(8 citation statements)

References 63 publications

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“…GO's the chemosensitizing activity was also demonstrated based on the enhanced anticancer activity. GO acted synergistically with the chemotherapeutic agents and perturbed the plasma membrane, disrupted the cytoskeleton meshwork, diverted the autophagy flux, enhanced nuclear imports, and induced necrosis [208]. There were indications for both direct and indirect interactions of GO with F-actin cytoskeleton assembly, which resulted in potential anticancer activity.…”

Section: Go As a Chemosensitisermentioning

confidence: 97%

“…There is evidence for the in vitro and in vivo toxicity of GO indifferent cancer cells and extremely low toxicity innormal cells. Bera S. et al showed that GO is more toxic to human colon cancer cells (HCT116) compared to human embryonic kidney epithelial cells (HEK293) [208] (Table 3). In HCT116 cells, GO disrupted the microtubule assembly, which led to cell cycle arrest in the S phase and induced apoptosis by generating reactive oxygen species (ROS) in a dose and time-dependent manner.…”

Section: Direct Killing Effect Of Graphene Oxidementioning

confidence: 99%

“…There were indications for both direct and indirect interactions of GO with F-actin cytoskeleton assembly, which resulted in potential anticancer activity. It has been shown that PEG-grafted GO entered the cell and interacted with the F-actin cytoskeleton, inducing cell cycle alterations, apoptosis, and oxidative stress [208].…”

Section: Go As a Chemosensitisermentioning

confidence: 99%

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Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.

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Section: Go As a Chemosensitisermentioning

confidence: 97%

Section: Direct Killing Effect Of Graphene Oxidementioning

confidence: 99%

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Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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“…Moreover, Bera and co-workers using different biophysical and cellular assays explored the effect of graphene oxide (GO) on tubulin structure and found that how the NPs-induced structural changes of proteins affect the tubulin/MT dynamics and resultant cytotoxicity [Fig. 6d(i)] [127]. It was seen that GO led to an apparent disruption in the structural integrity of the tubulin, with consequent inhibition of tubulin polymerization as evidenced by UV-Vis [Fig.…”

Section: Direct Interaction Of Inorganic Nps With Microtubulesmentioning

confidence: 99%

“…Copyright 2021 Elsevier. (d) The anticancer effect of graphene oxide (GO) NPs against human colon cancer cells (HCT116) mediated by destabilization of the tubulin assembly and oxidative stress (i), UV-Vis (ii) and fluorescence spectroscopy (iii) analyses of tubulin polymerization with increasing concentrations of GO[127]. Reprinted with permission from Ref [127]…”

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confidence: 99%

An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics

Zhang

Cho

Bloukh

et al. 2022

International Journal of Biological Macromolecules

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Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity

Yang

Zheng

et al. 2023

Adv Materials Technologies

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Bigels are novel biphasic systems containing hydrogel and oleogel structures, which are designed to deliver multiple bioactives for synergistic activity. The current study develops bigels based on a carrageenan hydrogel and a monoglyceride (GMS) oleogel. Results show that the microstructures of bigels are facilely modified by two surface active ingredients (Tween 20 and polyglycerol polyricinoleate), which then influence the microstructures of the bigels. When curcumin and epigallocatechin gallate (EGCG) are delivered simultaneously, the bioactives work synergistically to slow thermal degradation. Simulated digestion tests indicate that the bigel structures can delay the release of the two bioactives in artificial saliva and simulated gastric fluid (SGF), and allow fast release in simulated intestinal fluid (SIF). DPPH and ABTS tests show the digested Tween 20 bigels containing EGCG and curcumin present synergistic antioxidant activity. Anticancer activity is evaluated in human colon adenocarcinoma HCT116, and the two bioactives work cooperatively to lower cell viability. The bioactives released from Tween 20 bigels have higher cytotoxicity than those from polyglycerol polyricinoleate bigels. The results reveal that facile structural design of bigels has the potential to achieve synergistic stability and bioactivity of co‐delivered bioactives, which is meaningful for the development of functional pharmaceutical, cosmetic, and food products.

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Inhibition of microtubule assembly and cytotoxic effect of graphene oxide on human colorectal carcinoma cell HCT116

Cited by 13 publications

References 63 publications

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics

Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity

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