Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability

Abstract

Treatment with GSO-494 results in smaller atherosclerotic lesions with increased plaque stability. Inhibition of miR-494 may decrease the risk of surgical complications or even avert endarterectomy surgery in some cases.

Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494

“…A literature demonstrated miR-494 suppression decrease carotid artery atherosclerotic lesion, suggesting a potential reduction of the ischemic stroke risk [ 25 ]. Results in our study stated miR-494 was up-regulated after OGD and the up-regulation could be reversed by SSCE treatment, indicating that miR-494 was associated with the protective effect of SSCE on OGD-induced injury.…”

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

“…The 14q32 locus (12F1 in mice) encodes >50 microRNA genes, and we, and others, have previously shown that 14q32 microRNAs, as well as the other types of noncoding RNAs from this locus, play a vital regulatory role in many aspects of cardiovascular physiology and pathology. 4 , 14 , 41 , 42 , 43 , 44 , 45 , 46 Additionally, 14q32 microRNAs have been implicated in rapid placental growth during gestation by regulating capillary formation of the placenta’s labyrinth zone, which fits with the microRNAs’ regulatory roles in angiogenesis during adulthood. 47 We now show that A-to-I editing of 14q32 microRNAs also contributes to the regulatory role of this locus in vascular remodeling.…”

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

“…miR-494 has been shown to be highly upregulated in retinoblastoma 27 , cardiovascular pathologies such as cardiac injury 28 , and in atherosclerotic lesion development 29 . miR-494 has also been reported as an angiogenesis inhibitor, supporting our data here 30 – 32 .…”