Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation

Kim, Sang Bum; Zhang, Lu; Barron, Summer; Shay, Jerry W.

doi:10.1016/j.lssr.2014.02.001

Cited by 14 publications

(14 citation statements)

References 29 publications

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“…The exact mechanism of miR‐31 in radiosensitivity has not been elucidated (Lynam‐Lennon et al, ). A similar study demonstrated that inhibition of miR‐31‐5p protected human colon epithelial cells against ionizing radiation (Kim et al, ).…”

Section: Mir‐31 Promotes Radiation‐induced Apoptosismentioning

confidence: 73%

“…miR‐31 plays an important role in different types of cancers, including breast (Sossey‐Alaoui et al, ; Lu et al, ; Körner et al, ; Mulrane et al, ; Viré et al, ), ovarian (Anderson et al, ; Yu et al, ; Hassan et al, ), lung (Liu et al, ; Meng et al, ; Dong et al, ; Edmonds et al, ; Yu et al, ), colon (Cottonham et al, ; Cekaite et al, ; Xu et al, ; Kim et al, ; Li et al, ; Kurihara et al, ), and melanoma (Greenberg et al, ; Asangani et al, ). Intriguingly, even though the expression of miR‐31 is consistently altered in various cancers, miR‐31 can perform either tumor‐suppressive or oncogenic functions, depending on the type of cancer (Table ) (reviewed in Laurila and Kallioniemi, ).…”

Section: Role Of Mir‐31 In Cancer Is Context‐dependentmentioning

confidence: 99%

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Function and regulation of microRNA‐31 in development and disease

Stepicheva

Song

2016

Molecular Reproduction Devel

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SUMMARY MicroRNAs (miRNAs) are small noncoding RNAs that orchestrate numerous cellular processes both under normal physiological conditions as well as in diseases. This review summarizes the functional roles and transcriptional regulation of the highly evolutionarily conserved miRNA, microRNA-31 (miR-31). miR-31 is an important regulator of embryonic implantation, development, bone and muscle homeostasis, and immune system function. Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. Limited studies suggest that miR-31 is transcriptionally regulated by epigenetics, such as methylation and acetylation, as well as by a number of transcription factors. Overall, miR-31 regulates diverse cellular and developmental processes by targeting genes involved in cell proliferation, apoptosis, cell differentiation, and cell motility.

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Section: Mir‐31 Promotes Radiation‐induced Apoptosismentioning

confidence: 73%

Section: Role Of Mir‐31 In Cancer Is Context‐dependentmentioning

confidence: 99%

Function and regulation of microRNA‐31 in development and disease

Stepicheva

Song

2016

Molecular Reproduction Devel

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“…1). To perform the meta-analysis, we needed to exclude the Kim et al 25 study, 1 which measured the effect of irradiation on miRNA expression after more than half year after the exposure, whereas the median time for all other studies equaled 1 day (interquartile range, 0.17-2 days). Thus, we ended up with 112 miRNAs in 29 articles divided into 93 records (Table E1; available online at https://doi.org/ 10.1016/j.ijrobp.2019.10.028).…”

Section: Resultsmentioning

confidence: 99%

“…* Two studies provided data for both mixed and sex-specific groups (Fendler et al 2017 11 , both mixed and male group, Kim et al 25 for both mixed, male and female analysis).…”

Section: Resultsmentioning

confidence: 99%

“…In all but 1 study using single fraction, evaluated timepoints did not exceed 7 days. One study, clearly different from the remainders, was performed by Kim et al 25 and measured the effect of irradiation on miRNA expression after more than half year after the exposure. The studies evaluating the effects of fractionated radiation were done on humans undergoing radiation therapy for various cancers; however, in the majority of cases first evaluation of miRNA expression level was done at the end of the first week of treatment.…”

Section: Discussionmentioning

confidence: 99%

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Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis

Małachowska

Tomasik

Stawiski

et al. 2020

International Journal of Radiation Oncology*Biology*Physics

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Purpose: MicroRNAs (miRNAs) were hypothesized to be robust and easily measured biomarkers of radiation exposure, which has led to multiple studies in various clinical and experimental scenarios. We sought to identify evolutionary conserved, radiation-induced circulating miRNAs through a multispecies, integrative systematic review and meta-analysis of miRNAs in radiation. Methods and Materials: The systematic review was registered in the PROSPERO database (ID: 81701). We downloaded a list of studies with the query: (circulating OR plasma OR serum) AND (miRNA or microRNA) AND (radiat* OR radiotherapy OR irradiati*) from MEDLINE (103 studies), EMBASE (364 studies), and Cochrane Database of Systematic Reviews (0 studies). After deleting 116 duplicates, the remaining 351 abstracts were reviewed. Inclusion criteria were experimental study; human, mice, rat or nonhuman primate study; and serum or plasma miRNA expression measured before and after radiation exposure. Results: The screening procedure yielded 62 research studies. After verification, 30 articles contained data on miRNA expression change after irradiation. Thus, we obtained a database of 131 miRNAs from 96 pairwise post-/preirradiation comparisons reporting 2508 fold changes (FCs) of circulating miRNAs. The meta-analysis showed 28 miRNAs with significant radiation-induced change of their expression in the serum. In metaregression analysis, 7 miRNAsdmiR-150 (FC Z 0.40; 95% confidence interval [CI], 0.35-0.45), miR-29a (FC Z 0.87; 95% CI, 0.79-0.96), miR-29b (FC Z 0.85; 95% CI,

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MicroRNA regulation in hypoxic environments: differential expression of microRNAs in the liver of largemouth bass (Micropterus salmoides)

Sun

Zhao

et al. 2020

Fish Physiol Biochem

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Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation

Cited by 14 publications

References 29 publications

Function and regulation of microRNA‐31 in development and disease

Function and regulation of microRNA‐31 in development and disease

Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis

MicroRNA regulation in hypoxic environments: differential expression of microRNAs in the liver of largemouth bass (Micropterus salmoides)

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