Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest

Wang, Yongchao; Gu, Tingting; Shi, Enyi; Yu, Lei; Wang, Chun; Zhang, Yuhai; Qin, Fang

doi:10.1016/j.jtcvs.2015.04.062

Cited by 17 publications

(20 citation statements)

References 31 publications

(36 reference statements)

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“…Lentivirus vector was used to transfer agomiR and antagomiR in vitro and in vivo. 14,15 Chemically modified agomiR-30a and antagomiR-30a lentivirus gene transfer vectors were constructed by Genechem (Shanghai, China). Empty lentivirus agomiR-vectors or antagomiR-vectors were used as controls.…”

Section: Lentivirus Vectorsmentioning

confidence: 99%

Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase

Shi

et al. 2017

The Journal of Thoracic and Cardiovascular Surgery

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Section: Lentivirus Vectorsmentioning

confidence: 99%

Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase

Shi

et al. 2017

The Journal of Thoracic and Cardiovascular Surgery

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“…Aortic surgery patients are also at risk of neurological injury by prolonged deep hypothermia circulatory arrest. Inhibition of miR-29c was suggested as protective for the neurological function in a rat study (Wang et al, 2015). Albeit preliminary, these observation hold promise for future exploration (Squiers et al, 2015) as neurological injury is a devastating complication after cardiovascular surgery and few pharmacological agents or interventions are available to effectively protect the brain and spinal cord in the postoperative period (Torres and Ishida, 2015).…”

Section: Post-operative Complicationsmentioning

confidence: 91%

Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?

Biglino

Caputo

Rajakaruna

et al. 2017

Pharmacology & Therapeutics

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This review focuses on microRNAs (miRs) in cardiac surgery, where they are emerging as potential targets for therapeutic intervention as well as novel clinical biomarkers. Identification of the up/down-regulation of specific miRs in defined groups of cardiac surgery patients can lead to the development of novel strategies for targeted treatment in order to maximise therapeutic results and minimise acute, delayed or chronic complications. MiRs could also be involved in determining the outcome independently of complications, for example in relation to myocardial perfusion and fibrosis. Because of their relevance in disease, their known sequence and pharmacological properties, miRs are attractive candidates for therapeutic manipulation. Pharmacological inhibition of individual miRs can be achieved by modified antisense oligonucleotides, referred to as antimiRs, while miR replacement can be achieved by miR mimics to increase the level of a specific miR. MiR mimics can restore the function of a lost or down-regulated miR, while antimiRs can inhibit the levels of disease-driving or aberrantly expressed miRs, thus de-repressing the expression of mRNAs targeted by the miR. The main delivery methods for miR therapeutics involve lipid-based vehicles, viral systems, cationic polymers, and intravenous or local injection of an antagomiR. Local delivery is particularly desirable for miR therapeutics and options include the development of devices specific for local delivery, light-induced antimiR, and vesicle-encapsulated miRs serving as therapeutic delivery agents able to improve intracellular uptake. Here, we discuss the potential therapeutic use of miRNAs in the context of cardiac surgery.

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“…Adeno-associated viral vectors of GAS5 siRNA or control vectors were transfected in vivo by means of intracerebroventricular injection 14 days before DHCA, as reported previously. 17 Rats were included in the following protocol only if they had normal neurologic function 3 days after the injection.…”

Section: Inhibition Of Growth Arrest-specific 5 In Vivomentioning

confidence: 99%

“…A rat model of cardiopulmonary bypass (CPB) and DHCA was conducted according to the method described previously (Video 1). 17…”

Section: Establishment Of Deep Hypothermic Circulatory Arrestmentioning

confidence: 99%

Inhibition of long noncoding RNA growth arrest–specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats

Gao

Shi

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

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Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest

Abstract: Inhibition of miR-29c attenuates neurologic injuries induced by prolonged deep hypothermia circulatory arrest through a peroxisome proliferator-activated receptor gamma coactivator 1-alpha pathway.

Cited by 17 publications

References 31 publications

Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase

Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase

Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?

Inhibition of long noncoding RNA growth arrest–specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats

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