Inhibition of MicroRNA-129-5p Promotes Neuroinflammation and Cognitive Impairment
Lalit Kaurani,
Jiayin Zhou,
Ranjit Pradhan
et al.
Abstract:Frontotemporal dementia (FTD) is a neurodegenerative disorder that causes the frontal and temporal lobes of the brain to deteriorate over time. This leads to changes in behavior, language problems, and a loss of mental abilities. Dysregulation of microRNAs (miRNAs) has been linked to several neurodegenerative diseases, including FTD, which suggests that they could be used as both biomarkers and therapeutic targets. We looked at smallRNA sequencing data from the frontal and temporal brain tissue of FTD patients… Show more
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