Inhibition of methanol metabolism in mice with acetyl salicylic acid

Hassan, Azza; Elghamry, M. I.; Abdelhamid, Fatma

doi:10.1007/bf01900163

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1968

1970

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“…However, the protection by acetyl-salicyclic acid (0.5 g/kg) injected i.p. one hour before the LDso of methanol in mice is due to inhibition of the peroxidase systems (xanthine-oxidase, monoamino-oxidase) [8] . In view of the very high rate of ethanol oxidation in mice especially after lethal and toxic doses [9], the effect of orotate may be additive.…”

Section: Discussionmentioning

confidence: 99%