Inhibition of message for FcεRI α chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae

Luo, Danlin; Dai, Yuling; Duffy, Lynn B.; Atkinson, T. Prescott

doi:10.1016/j.micpath.2007.10.008

Cited by 5 publications

(3 citation statements)

References 39 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mast cell cytokine production is dependent upon the presence of sialic acid residues on the target cell membrane and the P1 adhesin. More recent studies have revealed that the activation process requires expression of the heavily sialylated FcɛRI α chain by the mast cell (Luo et al , 2007). A model of cellular activation has been developed in which adherence by the bacterium to surface sialoglycoproteins results in cellular activation through the normal receptor‐signaling mechanisms.…”

Section: Interaction With Host Immune Cells and Autoimmunitymentioning

confidence: 99%

Epidemiology, clinical manifestations, pathogenesis and laboratory detection ofMycoplasma pneumoniaeinfections: Figure 1

2008

View full text Add to dashboard Cite

Since its initial description in the 1940s and eventual elucidation as a highly evolved pathogenic bacterium, Mycoplasma pneumoniae has come to be recognized as a worldwide cause of primary atypical pneumonia. Beyond its ability to cause severe lower respiratory illness and milder upper respiratory symptoms it has become apparent that a wide array of extrapulmonary infectious and postinfectious events may accompany the infections in humans caused by this organism. Autoimmune disorders and chronic diseases such as asthma and arthritis are increasingly being associated with this mycoplasma, which frequently persists in individuals for prolonged periods. The reductive evolutionary process that has led to the minimal genome of M. pneumoniae suggests that it exists as a highly specialized parasitic bacterium capable of residing in an intracellular state within the respiratory tissues, occasionally emerging to produce symptoms. This review includes discussion of some of the newer aspects of our knowledge on this pathogen, characteristics of clinical infections, how it causes disease, the recent emergence of macrolide resistance, and the status of laboratory diagnostic methods.

show abstract

Section: Interaction With Host Immune Cells and Autoimmunitymentioning

confidence: 99%

Epidemiology, clinical manifestations, pathogenesis and laboratory detection ofMycoplasma pneumoniaeinfections: Figure 1

2008

View full text Add to dashboard Cite

show abstract

“…Two recent studies by Hoek and colleagues demonstate how M. pneumoniae stimulates production of IL-4 by mast cells in co-culture experiments [25,26]. Cytokine production by mast cells is dependent upon the presence of sialic acid residues on the target cell membrane and the P1 adhesin components of the attachment organelle, and requires expression of the heavily sialylated FcεRI α-chain by the mast cell [26].…”

Section: Innate and Adaptive Immune Responsementioning

confidence: 99%

“…Cytokine production by mast cells is dependent upon the presence of sialic acid residues on the target cell membrane and the P1 adhesin components of the attachment organelle, and requires expression of the heavily sialylated FcεRI α-chain by the mast cell [26]. Mycoplasma adherence to surface sialoglycoproteins results in cellular activation through the normal receptor signaling mechanisms.…”

Section: Innate and Adaptive Immune Responsementioning

confidence: 99%

New Insights into the Pathogenesis and Detection of Mycoplasma Pneumoniae Infections

2008

View full text Add to dashboard Cite

Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections in persons of all ages and may be responsible for up to 40% of community-acquired pneumonias. A wide array of extrapulmonary events may accompany the infections caused by this organism, related to autommunity or direct spread. This review includes a discussion of the latest knowledge concerning the molecular pathological basis of mycoplasmal respiratory disease, how the organism interacts with the host immune system and its association with the development of chronic conditions such as asthma, recent emergence of macrolide resistance and the status of laboratory diagnostic methods. Keywordsantimicrobial resistance; asthma; community-acquired pneumonia; cytadherence; enzyme-linked immunoassay; Mycoplasma pneumoniae; PCR Although more than 200 species in the genus Mycoplasma are now recognized, relatively few are pathogenic in humans. The best known and most intensely studied of these species is Mycoplasma pneumoniae. The initial descriptions of M. pneumoniae as a human pathogen, realization that it was not a virus, characterization of clinical manifestations of mycoplasmal respiratory disease, mode and extent of transmission, and development of serological assays began more than 40 years ago. However, very little was known at that time about how this mycoplasma interacts with and damages host cells, affects the immune system, and the extent to which it may mediate illness outside of the respiratory tract.Progress in understanding the biological properties of M. pneumoniae and its true role as a human pathogen have been hindered significantly over the years by its very slow replication rate (∼6 h), fastidious demands for successful laboratory cultivation and the relatively low sensitivity and specificity of the earliest complement fixation serological tests, which were much better suited for less antigenically complex viral pathogens. Until recent years, as more sophisticated laboratory techniques have become available, dependence on nonstandardized sero-logical tests performed in reference laboratories requiring measurement of antibodies in

show abstract

Mast Cells in Lung Inflammation

Moiseeva

Bradding

2011

Mast Cell Biology

View full text Add to dashboard Cite

Mast cells play an important role in the lung in both health and disease. Their primary role is to initiate an appropriate program of inflammation and repair in response to tissue damage initiated by a variety of diverse stimuli. They are important for host immunity against bacterial infection and potentially in the host immune response to non small cell lung cancer. In situations of ongoing tissue damage, the sustained release of numerous pro-inflammatory mediators, proteases and cytokines, contributes to the pathophysiology of lung diseases such as asthma and interstitial lung disease. A key goal is the development of treatments which attenuate adverse mast cell function when administered chronically to humans in vivo. Such therapies may offer a novel approach to the treatment of many life-threatening diseases.

show abstract

Inhibition of message for FcεRI α chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae

Cited by 5 publications

References 39 publications

Epidemiology, clinical manifestations, pathogenesis and laboratory detection ofMycoplasma pneumoniaeinfections: Figure 1

Epidemiology, clinical manifestations, pathogenesis and laboratory detection ofMycoplasma pneumoniaeinfections: Figure 1

New Insights into the Pathogenesis and Detection of Mycoplasma Pneumoniae Infections

Mast Cells in Lung Inflammation

Contact Info

Product

Resources

About