Inhibition of melanogenesis by <i>β</i>‐caryophyllene from lime mint essential oil in mouse B16 melanoma cells

Yang, Chao‐Hsun; Huang, Yu‐Chun; Tsai, Max; Cheng, Ching-Yuan; Liu, L.-L.; Yen, Ying‐Tzu; Chen, W.-L.

doi:10.1111/ics.12224

Cited by 35 publications

(24 citation statements)

References 19 publications

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“…Although research on BPEO is fairly scarce, there is a fair amount of research on its isolated chemical constituents in skin disease models. For example, caryophyllene, the primary constituent of BPEO, was found to inhibit tumor growth in a B16F10 melanoma cell line (Yang et al, ). Consistent with this finding, our results show BPEO influences the regulation of oncogenes in skin cells.…”

Section: Resultsmentioning

confidence: 99%

Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells

Han¹,

Beaumont²,

Rodriguez³

et al. 2018

Phytotherapy Research

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Very few studies have investigated the biological activities of black pepper essential oil (BPEO) in human cells. Therefore, in the current study, we examined the biological activities of BPEO in cytokine-stimulated human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. BPEO exhibited significant antiproliferative activity in these skin cells and significantly inhibited the production of Collagen I, Collagen III, and plasminogen activator inhibitor 1. In addition, we studied the effect of BPEO on the regulation of genome-wide expression and found that BPEO diversely modulated global gene expression. Further analysis showed that BPEO affected many important genes and signaling pathways closely related to metabolism, inflammation, tissue remodeling, and cancer signaling. This study is the first to provide evidence of the biological activities of BPEO in human dermal fibroblasts. The data suggest that BPEO possesses promising potential to modulate the biological processes of tissue remodeling, wound healing, and metabolism. Although further research is required, BPEO appears to be a good therapeutic candidate for a variety of health conditions including wound care and metabolic diseases. Research into the biological and pharmacological mechanisms of action of BPEO and its major active constituents is recommended.

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Section: Resultsmentioning

confidence: 99%

Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells

Han¹,

Beaumont²,

Rodriguez³

et al. 2018

Phytotherapy Research

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“…Many EOs are rich in compounds that act as competitive inhibitors on the enzyme tyrosinase that can lead to reduced melanin synthesis . EOs with inhibitory activity of tyrosinase can be useful targets to treat skin disorders associated with hyper‐pigmentation . Therefore, EOs may be potential agents for skin whitening.…”

Section: Discussionmentioning

confidence: 99%

“…[23][37] [38] EOs with inhibitory activity of tyrosinase can be useful targets to treat skin disorders associated with hyper-pigmentation. [37] [40] Therefore, EOs may be potential agents for skin whitening.…”

Section: 3mentioning

confidence: 99%

Chemical Composition, Antioxidant and Anti‐melanogenic Activities of Essential Oils from Chrysanthemum boreale Makino at Different Harvesting Stages

Kim

Won

Hwang

et al. 2018

Chemistry & Biodiversity

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In the present study, the chemical compositions and skin whitening-related antioxidant and anti-melanogenic effect of essential oils (EOs) extracted from Chrysanthemum borealeMakino (CBM) (CBMEOs) at vegetative, pre-flowering and full-flowering are investigated and contrasted among the three stages. The yields and components of the CBMEOs were different at each stage. The CBMEOs increased DPPH and ABTs scavenging activities and attenuated the α-melanocyte stimulating hormone (α-MSH)-induced tyrosinase activity and melanin synthesis in B16BL6 cells. Among CBMEO components, eugenol had the highest DPPH and ABTs scavenging activities and cuminaldehyde was the strongest inhibitor of α-MSH-induced tyrosinase activity and melanin synthesis. The CBMEOs in each stage showed the different levels of phosphorylation of extracellular signal-regulated kinase1/2 and p38 MAPK. These findings demonstrate that the CBMEOs have antioxidative and anti-melanogenic activities in all the CBM harvesting stages, resulting in skin-whitening biological activities and that the levels of their component contents and bioactivities differ among the CBM harvesting stages. The CBMEOs may have the potential for use in cosmetics and alternative medicine.

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“…This might be due to the compounds present in these types of extracts (mainly mono-and sesquiterpenes). This observation already shows through the literature survey: compared to solvent extracts, only a few studies report the tyrosinase inhibition and/or anti-melanogenic effects of such extracts or of individual EOs' constituents [87,166,[176][177][178][179][180][181]. Single components, mainly acting as alternative substrates to L-Tyrosine and L-DOPA (eugenol, thymol, etc.…”

Section: Lab Reality: Our Experiencementioning

confidence: 97%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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Abstract:With the public's growing interest in skin whitening, lightening ingredients only used under dermatological supervision until recently, are more and more frequently incorporated into cosmetic formulas. The active agents that lighten skin tone are either natural or synthetic substances, and may act at various levels of melanogenesis. They are used to treat various skin pigmentation disorders or simply to obtain a lighter skin tone as whiter skin may be synonymous of wealth, health, youth, and/or beauty in different cultures. However, recent studies demonstrated the adverse effects of some of these ingredients, leading to their interdiction or restricted use under the European Directive and several other international regulations. After an overview of skin whitening practices and the associated risks, this article provides insight into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients. The legislation dealing with the use of skin lighteners is then discussed. As traditional depigmenting agents such as hydroquinone and corticosteroids are of safety concern, the potential of natural extracts has been investigated more and more; finally, a synthesis of three years of research in our laboratory for such plant extracts will be given.

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Inhibition of melanogenesis by β‐caryophyllene from lime mint essential oil in mouse B16 melanoma cells

Abstract: These results reveal that lime mint essential oil and β-caryophyllene are considered to be valuable as potential skin-whitening agents.

Cited by 35 publications

References 19 publications

Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells

Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells

Chemical Composition, Antioxidant and Anti‐melanogenic Activities of Essential Oils from Chrysanthemum boreale Makino at Different Harvesting Stages

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

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