“…The first report about desensitization to adenosine was in neuroblastoma cells in tissue culture (Green, 1977), although a clear demonstration of this phenomenon was also reported by McNeal et al (1980) in guinea-pig cerebral cortex. Desensitization to adenosine has been reported in different tissues such as hippocampus (Lee et al, 1986;Porter et al, 1988), striatum (Porter et al, 1988;Abbracchio et al, 1992;), neocortex (McNeal et al, 1980Porter et al, 1988;Abbracchio et al, 1993), locus coeruleus (Regenold & Illes, 1990), neuroblastoma (Kenimer & Nirenberg, 1981;Kelly et al, 1990), liver (Buxton et al, 1987), kidney (Newman & Levitzki, 1983), smooth muscle (Hayashi et al, 1985;Ramkumar et al, 1991), vascular smooth muscle (Anand-Strivastava et al, 1989;Hussain & Mustafa, 1993), heart or myocytes (Shryock et al, 1989;Liang & Donovan, 1990), endothelial cells (Luty et al, 1989), mast cells (Marquardt & Walker, 1987), adipocyte cells (Parsons & Stiles, 1987;Hoffman et al, 1989;Longabaugh et al, 1989;Stoneham, 1989). Adenosine desensitization was seen both in vivo (Lee et al, 1986) and in vitro (Abbracchio et al, 1992).…”