Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds

Menon, Lata G.; Kuttan, Ramadasan; Kuttan, Girija

doi:10.1016/0304-3835(95)03887-3

Cited by 194 publications

(102 citation statements)

References 9 publications

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“…More recently, others have studied the antitumoral and inhibitory effects of curcumin on melanoma cells [141] and melanoma lung metastasis in mice [147].…”

Section: Curcumin Exhibits Antitumor Activity In Animalsmentioning

confidence: 99%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,859

1,267

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“…More recently, others have studied the antitumoral and inhibitory effects of curcumin on melanoma cells [141] and melanoma lung metastasis in mice [147].…”

Section: Curcumin Exhibits Antitumor Activity In Animalsmentioning

confidence: 99%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,859

1,267

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“…Curcumin alone induced a 49-55% reduction in mean tumor growth compared with control animals, while the combination of curcumin with docetaxel resulted in a 77% reduction in mean tumor growth compared with the controls. In both cases, curcumin induced a decrease of proliferation and microvessel density and a significant increase in tumor cell apoptosis (78). In a recent in vitro study, the authors showed that the combination of curcumin and triptolide was able to synergistically inhibit ovarian cancer cell growth (79).…”

Section: Ovarian Cancermentioning

confidence: 99%

“…In order to evaluate the effect of curcumin against ovarian cancer, a group of animals were treated with curcumin alone or in combination with docetaxel (78). Curcumin alone induced a 49-55% reduction in mean tumor growth compared with control animals, while the combination of curcumin with docetaxel resulted in a 77% reduction in mean tumor growth compared with the controls.…”

Section: Ovarian Cancermentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

245

181

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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“…This pharmacokinetic feature of curcumin, which has been observed across several species, is the result of poor absorption and avid metabolic conjugation and reduction Sharma et al, submitted for publication). Despite the evidence that curcumin is poorly available following oral administration, there are reports that curcumin at 50 -200 mg kg À1 doses exerts biological activity on sites distant from the locus of absorption in rodents, such as breast (Inano and Onoda, 2002), prostate (Frank et al, 2003), lung (Menon et al, 1995) and especially the liver (Busquets et al, 2001;Park et al, 2001;Nanji et al, 2003). Studies on gall bladder contractility following oral curcumin in humans suggest that curcumin may exert biological actions at doses of 20 mg (Rasyid & Lelo 1999;Rasyid et al, 2002).…”

mentioning

confidence: 99%

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

et al. 2004

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Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration of curcumin results in concentrations of the agent in normal and malignant human liver tissue, which are sufficient to elicit pharmacological activity. In total, 12 patients with hepatic metastases from colorectal cancer received 450 -3600 mg of curcumin daily, for 1 week prior to surgery. Levels of curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue. Curcumin was poorly available, following oral administration, with low nanomolar levels of the parent compound and its glucuronide and sulphate conjugates found in the peripheral or portal circulation. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected. In patients who had received curcumin, levels of malondialdehyde-DNA (M 1 G) adduct, which reflect oxidative DNA changes, were not decreased in post-treatment normal and malignant liver tissue when compared to pretreatment samples. The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans.

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Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds

Cited by 194 publications

References 9 publications

Curcumin as “Curecumin”: From kitchen to clinic

Curcumin as “Curecumin”: From kitchen to clinic

Biological and therapeutic activities, and anticancer properties of curcumin

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

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