Inhibition of lipid peroxidation in mitochondria isolated from the liver of hypothyroid rabbits

Marzoev, A. I.; Козлов, А. В.; Vladimirov, Yu. A.

doi:10.1007/bf00834000

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…Significantly elevated level of hepatic TBARS found in the course of induced hyperthyroidism (Kappus, 1985) is considered to represent a breakdown product of polyunsaturated fatty acids undergoing free radical action. Opposite changes are expected to occur in hypothyroid animals (Marzoev et al, 1982b).…”

Section: Discussionmentioning

confidence: 99%

Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits

Brzezińska-Ślebodzińska

2003

Acta Veterinaria Hungarica

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The effect of hypothyroidism on some oxidative stress parameters is reported. Moderate hypothyroid state was induced in two groups of female rabbits (3 and 12 months old) by giving 50 mg/kg body weight (BW) of propylthiouracil (PTU) per os for 6 days and 20 mg/kg BW of methimazole (MMI) for further 14 days. Serum T 4 and T 3 concentrations decreased by about 38-40 and 32-36%, respectively. The induced hypothyroidism resulted in a significant decrease in the serum concentration of the lipid peroxidation end-product malondialdehyde, as measured by the thiobarbituric-acid assay. Erythrocytes of hypothyroid animals exhibited higher resistance to oxidative stress, while submitted to free radicals generator 2,2'-azo-bis(2-amidinopropane) hydrochloride (AAPH) in vitro. Using two detector systems (phospholipid liposomes and deoxyribose), sensitive to either organic or inorganic oxygen radical damage, the ability of euthyroid and hypothyroid rabbit plasma to protect against oxygen radicals was evaluated. The plasma of hypothyroid animals showed about 20% higher ability to protect against iron-binding organic radicals, but about 50% lower chain-breaking antioxidant activity. The antioxidant capacity of plasma against inorganic radicals was not affected by hypothyroidism. In conclusion, the results show that thyroid hormones modulate the free-radical-induced oxidative damage of lipids and that hypothyroidism offers some protection against lipid peroxidation.Key words: Hypothyroidism, oxidative stress, lipid peroxidation, free radicals While the biochemical knowledge on free radical metabolism is well documented, there is little information on the endocrine control of oxidative stress. The involvement of thyroid hormones in lipid peroxidation and antioxidant enzyme activities has been studied mainly in liver tissue (Venditti et al

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Section: Discussionmentioning

confidence: 99%

Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits

Brzezińska-Ślebodzińska

2003

Acta Veterinaria Hungarica

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“…Spontaneous UPE of mitochondria in the optical spectral range (from ultraviolet to infrared) could be detected however by several other groups [ 92 – 94 ], and it has been demonstrated that the UPE emission from mitochondria can be enhanced by the addition of iron [ 95 – 97 ], acetaldehyde [ 98 ], H 2 O 2 or tert-butyl hydroperoxide [ 93 ], succinate [ 94 ], NADH [ 94 ], or a cocktail of doxorubicin and iron(III) chloride [ 99 ]. That mitochondria emit UPE even in the ultraviolet range was demonstrated by Zhuralev et al [ 92 ] measuring UPE from isolated liver mitochondria of rats using a photomultiplier sensitive in the spectral range of approx.…”

Section: Novel Findings Regarding Membrane Nanotubes and Mitochondriamentioning

confidence: 99%

Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis

Scholkmann

2016

Theor Biol Med Model

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Coordinated interaction of single cells by cell-to-cell communication (signalling) enables complex behaviour necessary for the functioning of multicellular organisms. A quite newly discovered cell-to-cell signalling mechanism relies on nanotubular cell-co-cell connections, termed “membrane nanotubes” (MNTs). The present paper presents the hypothesis that mitochondria inside MNTs can form a connected structure (mitochondrial network) which enables the exchange of energy and signals between cells. It is proposed that two modes of energy and signal transmission may occur: electrical/electrochemical and electromagnetic (optical). Experimental work supporting the hypothesis is reviewed, and suggestions for future research regarding the discussed topic are given.

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The response of rat liver lipid peroxidation, antioxidant enzyme activities and glutathione concentration to the thyroid hormone

Morini

Casalino

Sblano

et al. 1991

International Journal of Biochemistry

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Inhibition of lipid peroxidation in mitochondria isolated from the liver of hypothyroid rabbits

Cited by 5 publications

References 3 publications

Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits

Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits

Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis

The response of rat liver lipid peroxidation, antioxidant enzyme activities and glutathione concentration to the thyroid hormone

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