Inhibition of leucocyte migration by salicylates and indomethacin

The enhancement of dextran anaphylactoid reaction in the rat by sodium salicylate

“…I n the rat it is genetically controlled (Harris et al 1963), just as are many allergic states in man. Doses of sodium salicylate above 100 mg kg-' reduce the reaction (Warne & West 1978), as d o aspirin and indomethacin, but the effects of much smaller doses of salicylate have not been studied in detail.…”

Circannual Variations in Carrageenan-Induced Paw Edema and in the Anti-Inflammatory Effect of Phenylbutazone in the Rat

“…The efflux of pi neal cyclic GMP produced by administration of /-norepinephrine or potassium chloride was markedly reduced during January and February [13] and vasopressin secretion in rats was much lower in winter than during the summer [21], Seasonal variations were also observed in the effects of nonsteroidal anti-inflammatory drugs. Warne and West [16,17] noted that doses of aspirin, which were effective inhibitors of cell migration during the winter months, failed to produce inhibition in the summer. A partial return of the inhibitory effect of the salicylate was noted during the period of September to November.…”

Seasonal Variation in Drug Action and Animal Responses in Models of Inflammation

“…At this time period, rats were insensitive to intravenous histamine and relatively insensitive to anaphylactic shock, and survival rates after traumatic or tourniquet shock have also been reported to be at peak values. The cause of this resistance has still to be found, though hormonal activation may play a major role.Whilst studying the effets of drugs on leucocyte migration into the pleural space in flamed by carrageenan and into inert poly vinyl sponges implanted subcutaneously in rats, Warne and West [6] noted that doses of salicylates, which were effective inhibi tors of cell migration during the winter months, suddenly failed to produce inhibi tion in the summer. This result was in sharp contrast to that using indomethacin which retained its inhibitory effect throughout the year.…”

“…Groups of 5 male Wislar rats (Tuck Ltd., Rayleigh, Es sex) were used and the techniques have been described [6]. Briefly, carrageenan was injected into the pleural space to induce a migration, 24 h later, of leucocytes (poly morphs 60%, mononuclears 40%) and the inhibitory effects of oral aspirin (225 mg kg') and indomethacin (10 mg kg ') giv en 24 and 1 h before the stimulus were de termined at different times of the year.…”