Inhibition of lens aldose reductase by flavonoids

Shimizu, Mineo; Ito, Toshimi; Terashima, Satoshi; Hayashi, Toshimitsu; Arisawa, Munehisa; Morita, Naokata; Kurokawa, Shigeki; Itō, Kiyoshi; Hashimoto, Yoshiro

doi:10.1016/s0031-9422(00)84935-3

Cited by 81 publications

(56 citation statements)

References 8 publications

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“…The re ac tion was ini ti ated by the ad di tion of aldose reductase, and the rate of ox i da tion from NADPH to NADP was ob served by the de crease in the absorbancy at 340 nm 1 .…”

Section: Ma Te Rial and Methodsmentioning

confidence: 99%

“…Flavonoids that are pres ent in higher plants, mainly legu mi nous, have aroused in ter est be cause of their in hib i tory ac tion on aldose reductase 1,2,3 . Aldose reductase ca tal y ses the re duc tion of glu cose and galactose, pro duc ing sorbitol and dulcitol re spec tively, us ing NADH as a co-factor 4 .…”

Section: Introductionmentioning

confidence: 99%

“…It has been dem on strated that cat a ract forma tion ceases un der the sys temic ad min is tra tion of aldose reductase in hib i tors 7,8 . In or der to solve this prob lem several com pounds have been tested 6,8,9,10 , be sides flavonoids 1,3 . The pur pose of the pres ent study is to iso late, pu rify and iden tify flavonoidic com pounds of the UFV-5' soy bean's cultivar, as well as to test their in hib i tory ac tion in aldose reductase in vi tro .…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory action on aldose reductase by soybean flavonoids

Oliveira¹,

Nagem²,

Miranda³

et al. 1997

J. Braz. Chem. Soc.

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Os flavonóides kaempherol, genisteína, naringenina, quercetina, morina, rutina, e quercitrina isolados do cultivar de soja UFV-5' foram testados como inibidores de aldose redutase. Os melhores resultados foram obtidos usando morina e quercitrina.The flavonoids kaempherol, genistein, naringenin, quercetin, morin, rutin and quercitrin iso lated from UFV-5'soybean's cultivars were tested as in hib i tors of aldose reductase. The best re sults were ob tained by us ing morin and quercitrin. Key words: flavonoids, soy bean, aldose reductase In tro duc tionFlavonoids that are pres ent in higher plants, mainly legu mi nous, have aroused in ter est be cause of their in hib i tory ac tion on aldose reductase 1,2,3 . Aldose reductase ca tal y ses the re duc tion of glu cose and galactose, pro duc ing sorbitol and dulcitol re spec tively, us ing NADH as a co-factor 4 . This en zyme has been found in many an i mal tis sues, such as the ret ina, blood, the cor nea, the sci atic nerve, the liver, kidneys and sperm.The ex ces sive pres ence of sorbitol in di a betic rats and hu mans causes the for ma tion of cat a racts 2,5,6 . A sim i lar result was also ob served by the pres ence of dulcitol in the lenses of rats main tained on a diet rich in galactose 7 . In the lenses of di a betic rats the con tent of sorbitol may be as high as 50 µmol/g, while in the lenses of galactosemic rats, the level of dulcitol can rise to ap prox i mately 80 µmol/g wet weight tis sue 4 . It has been dem on strated that cat a ract forma tion ceases un der the sys temic ad min is tra tion of aldose reductase in hib i tors 7,8 . In or der to solve this prob lem several com pounds have been tested 6,8,9,10 , be sides flavonoids 1,3 . The pur pose of the pres ent study is to iso late, pu rify and iden tify flavonoidic com pounds of the UFV-5' soy bean's cultivar, as well as to test their in hib i tory ac tion in aldose reductase in vi tro . Ma te rial and MethodsThe flavonoids kaempherol (I), genistein (II), quercetin (III), naringenin (IV), morin (V), rutin (VI) and quercitrin (VIII) were ex tracted from the UFV-5'soybean's cultivar, fol low ing Hardin's tech nique 11 . The sam ple was heated in a bath-water with ace tic acid for 10 min, and then fil tered. The fil trate was treated with HCl 1 N for one hour, and then ex tracted with an hy drous ethyl ether which was evap o rated giv ing a res i due con tain ing flavonoidic com po nents isolated by chro ma tog ra phy.Ar ti cle

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“…The re ac tion was ini ti ated by the ad di tion of aldose reductase, and the rate of ox i da tion from NADPH to NADP was ob served by the de crease in the absorbancy at 340 nm 1 .…”

Section: Ma Te Rial and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitory action on aldose reductase by soybean flavonoids

Oliveira¹,

Nagem²,

Miranda³

et al. 1997

J. Braz. Chem. Soc.

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show abstract

“…The polyphenols in the iso-octane soluble fraction were detected (not data shown). The polyphenols and the flavonoids are known aldose reductase inhibitors 19,22 .…”

Section: -Rlmfmxmsr Sj Ephswi Vihygxewi Egxmzmx] F] XLI Mws Sgxeri Jvmentioning

confidence: 99%

“…2, the aldose reductase activity was inhibited by extracts from malt that were prepared without hops. Many polyphenols are known to be potent inhibitors of aldose reductase 8,19,22 . The wort prepared with malt contained 200 mg/L polyphenol.…”

Section: (-7'977-32mentioning

confidence: 99%

Inhibition of Aldose Reductase Activity by Extracts from Hops

Shindo

Tomatsu

Nakda

et al. 2002

Journal of the Institute of Brewing

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The inhibitory effect of beer on aldose reductase was investigated. Components present in beer strongly inhibited aldose reductase. Inhibition activity was observed primarily in the methanol-soluble fraction of the beer and active components were identified to be of hop origin. Further, a component was identified as iso-␣-acids, which are well known as main bitter components of beer. The inhibition rate of iso-␣-acids was similar to quercetin, which is known to be a strong inhibitor of aldose reductase activity.

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Antioxidant and aldose reductase inhibition activity of Ligustrum japonicum and Olea europaea L. leaf extracts

Papoti

Pegklidou

Perifantsi

et al. 2011

Euro J Lipid Sci & Tech

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Ligustrum japonicum and Olea europaea leaf extracts prepared via domestic techniques were studied for antioxidant and aldose reductase inhibitory activity (ARI) in relation to individual phenol/flavonoid composition (HPLC-various detection means) and content. On the same extract weight basis L. japonicum leaf extracts, poorer in total polar phenol (TPP) content and in most cases in flavonoids, were less efficient than olive leaf extracts in radical scavenging and in retarding lipid oxidation. On the same TPP content basis, the former were of comparable efficiency in radical scavenging but exhibited lower activity than the latter in bulk oils or liposomes. L. japonicum extracts were characterized by the presence of verbascoside and apigenin derivatives, whereas O. europaea extracts by that of oleuropein. Superiority of L. japonicum infusion versus O. europaea infusion was evidenced using the ARI activity assay either on the same extract weight or on TPP content basis. The former was also superior in comparison to oleuropein, tyrosol, and hydroxytyrosol activity. These findings suggest the presence of other active compounds besides the so far identified phenolics and enhance our view on the importance of Oleaceae plants as sources of bioactive compounds beyond O. europaea.Practical applications: Oleaceae plants are a unique source for the secoiridoid oleuropein or verbascoside that confer well documented biological properties. On continuation of our effort to valorize plants of this family as sources for functional constituents we examined, in parallel, leaf extracts of the less investigated species Ligustrum japonicum versus those of Olea europaea L. The data presented for the extracts obtained via domestic preparations techniques (infusions, decoctions, tinctures) are expected to attract the interest of those involved in herbal teas and dietary supplements sector.

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Inhibition of lens aldose reductase by flavonoids

Cited by 81 publications

References 8 publications

Inhibitory action on aldose reductase by soybean flavonoids

Inhibitory action on aldose reductase by soybean flavonoids

Inhibition of Aldose Reductase Activity by Extracts from Hops

Antioxidant and aldose reductase inhibition activity of Ligustrum japonicum and Olea europaea L. leaf extracts

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