Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of <i>Alpinia zerumbet</i>: possible involvement of an antioxidant effect

Araújo, Fernanda Yvelize Ramos de; Oliveira, Gersilene Valente de; Gomes, Patrícia; Soares, Marília Almeida; Silva, Maria Izabel Gomes; Carvalho, André F.; Moraes, Manoel Odoríco de; Moraes, Maria Elisabete Amaral de; Vasconcelos, Silvânia Maria Mendes; Viana, Glauce Socorro Barros; Sousa, Francisca Cléa Florenço de; Macêdo, Danielle Silveira

doi:10.1111/j.2042-7158.2011.01312.x

Cited by 26 publications

(21 citation statements)

References 44 publications

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“…The fruit was identified by Professor Chen Zu-yun, and a voucher specimen (No.20091026) was deposited at the Research Division of Pharmacology, Guiyang Medical University. The isolation of the essential oil was carried out at the school of Pharmacy of the Guiyang Medical University, according to a method described elsewhere [13]. Briefly, chopped fruit was placed in a glass flask connected at one end to a glass vessel with water and at the other end to a water-cooled condenser.…”

Section: Methodsmentioning

confidence: 99%

Evidence-based antioxidant activity of the essential oil from Fructus A. zerumbet on cultured human umbilical vein endothelial cells’ injury induced by ox-LDL

Shen

Tao

et al. 2012

BMC Complement Altern Med

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BackgroundThe essential oil from Fructus Alpiniae zerumbet (FAZ) is its principal bioactive ingredient, and is widely used in Miao folk herbs in Guizhou province for the treatment of gastrointestinal and cardiovascular diseases. Several studies have confirmed that FAZ ameliorates hyperlipidemia and atherosclerosis. Because endothelial dysfunction often accompanies cardiovascular diseases, especially hyperlipidemia and atherosclerosis, the present study concentrated on evaluating the endothelial protective effects of the essential oil from FAZ (EOFAZ) on oxidized low-density lipoprotein (ox-LDL)-induced injury of cultured human umbilical vein endothelial cells (HUVECs) and on the regulation of oxidative stress.MethodsCell viability was analyzed with the MTT assay and trypan blue exclusion staining (TBES). Cell injury was assessed by lactate dehydrogenase (LDH) release. Biochemical enzymatic methods were used to evaluate the oxidative stress, including the lipid peroxidation product, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px).ResultsThe redox status of HUVECs was significantly exacerbated after exposure to ox-LDL. EOFAZ protected HUVECs against ox-LDL injury as assessed by the MTT assay, TBES and LDH release. Furthermore, EOFAZ ameliorated the oxidative stress by elevating the activities of SOD, CAT and GSH-Px, and increasing the GSH levels, in addition to attenuating the MDA contents.ConclusionsThe present data provide the first experimental evidence that EOFAZ protects endothelial cells against ox-LDL-induced injury, and indicate that this protection involves ameliorating the redox status.

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Section: Methodsmentioning

confidence: 99%

Evidence-based antioxidant activity of the essential oil from Fructus A. zerumbet on cultured human umbilical vein endothelial cells’ injury induced by ox-LDL

Shen

Tao

et al. 2012

BMC Complement Altern Med

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“…Diverse plants with neuroactive properties, for example, Panax quinquefolium Linn (Araliaceae) (Chatterjee et al, 2012b), Alpinia zerumbet (Pers.) B. L. Burtt (Zingiberaceae) (de Araujo et al, 2011), Lonchocarpus cyanescens (Schumach and Thonn.) Benth.…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

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(2015) Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems, Pharmaceutical Biology, 53:12, 1850-1860, DOI: 10.3109/13880209.2014 (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies.Results: BM reduced ketamine-induced hyperactivity with an EC 50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily Â 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. Discussion and conclusion: Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.

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“…Previous studies indicate that inward currents in motoneurons are mediated by L-type calcium channel [33]. Here, the assumption of a central Ca 2+ -mediated action finds support because the systemic administration of EOAz triggers effects on the central nervous system [34,35]. In addition, the vasorelaxant and antihypertensive effects of a methanolic fraction of EOAz (MFEOAz) were related to an inhibition of the calcium influx via voltage-operated calcium channels, receptor-operated calcium channels and L-type calcium channels [3].…”

Section: Discussionmentioning

confidence: 83%

The Effect of Alpinia zerumbet Essential Oil on Post‐Stroke Muscle Spasticity

Maia

Dantas

Filho

et al. 2015

Basic Clin Pharma Tox

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The essential oil of Alpinia zerumbet (EOAz) presents myorelaxant and antispasmodic actions on cardiac and smooth muscles. The aim of this study was to investigate the effect of EOAz on the skeletal muscle contraction in post-stroke spasticity. Fifteen adults with unilateral hemiparesis and spasticity resulting from stroke were submitted to surface electromyography readings of the gastrocnemius muscle, before and after 10 daily applications (dermal 0.05 mL per muscle belly) of EOAz. The healthy contralateral muscles without applying the oil were used as controls. The analysis showed that, in both lateral and medial gastrocnemius, the values of all studied variables (root mean square, maximum amplitude and median power frequency) were significantly decreased in pathological legs during muscle contraction (Wilcoxon test, p < 0.05). Moreover, spastic muscles presented different results before and after dermal application of EOAz: The mean values of root mean square and median power frequency were significantly increased in lateral and medial gastrocnemius, and also, the maximum amplitude increased in medial gastrocnemius (Mann-Whitney test, p < 0.05). The results suggest that EOAz acts in the skeletal spastic muscle contraction by promoting relaxation and improvement of the muscular performance. Thus, the EOAz can be useful for the clinical management of secondary effects in patients with cerebral vascular disease.The Alpinia speciosa K. Schum., synonymy zerumbet, is a plant of Asian origin and member of the Zingiberaceae family [1,2]. It is widely distributed in Brazil, where it is popularly called 'colony'. The essential oil and extracts obtained from aerial parts of Alpinia zerumbet present antihypertensive [3][4][5][6], antioxidant [7,8] and anxiolytic [9] activities, among others.Some actions of essential oil of Alpinia zerumbet (EOAz) and its main constituents have been reported on the nervous and muscular systems. In experimental studies, the EOAz presented anticholinergic, antispasmodic and myorelaxant effects on small intestine of rodents [10,11]; promoted a dose-dependent blockade of the compound action potential of the rat sciatic nerve [12]; and presented endothelium-dependent vasorelaxant effect [4,13]. Also, the oil induced a cardiodepressive effect in vitro, this action being related to calcium current blockade [14]. These findings raise the possibility that the EOAz can act on altered contractile properties of skeletal fibres.In stroke patients, spasticity occurs as a result of spinal reflex dysfunction and is clinically related to abnormal increased muscle tone [15] and consequent impaired muscular performance [16]. This illness causes disabilities in more than 50% of affected people and impacts family and healthcare systems [17]. The current treatments are not fully effective, and new therapeutic strategies are desirable.From the hypothesis that EOAz could be a complementary medicine to treat spasticity by presenting relaxant action, this work aimed to investigate the effects of the derm...

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Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect

Abstract: The results suggest antipsychotic and antioxidant effects for the EOAZ that may have promising efficacy for the treatment of schizophrenia.

Cited by 26 publications

References 44 publications

Evidence-based antioxidant activity of the essential oil from Fructus A. zerumbet on cultured human umbilical vein endothelial cells’ injury induced by ox-LDL

Evidence-based antioxidant activity of the essential oil from Fructus A. zerumbet on cultured human umbilical vein endothelial cells’ injury induced by ox-LDL

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

The Effect of Alpinia zerumbet Essential Oil on Post‐Stroke Muscle Spasticity

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