Inhibition of Jejunal Water and Electrolyte Absorption by Therapeutic Doses of Clindamycin in Man

Spiller, Robin C.; Higgins, B. E.; Fröst, Peter; Silk, D. B. A.

doi:10.1042/cs0670117

Cited by 6 publications

(3 citation statements)

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“…The test solution comprised 145 mM l −1 NaCl and 15 mM l −1 mannitol in water. This solution was chosen since it was previously shown, using the intestinal perfusion technique, to induce no net fluid flux (absorption) when infused into a jejunal segment (Spiller et al 1984). Immediately after each bolus was infused an MRCP data set was acquired.…”

Section: Intubation and Mr Imagingmentioning

confidence: 99%

Non-invasive quantification of small bowel water content by MRI: a validation study

Hoad¹,

Marciani²,

Foley³

et al. 2007

Phys. Med. Biol.

118

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Substantial water fluxes across the small intestine occur during digestion of food, but so far measuring these has required invasive intubation techniques. This paper describes a non-invasive magnetic resonance imaging (MRI) technique for measuring small bowel water content which has been validated using naso-duodenal infusion. Eighteen healthy volunteers were intubated, with the tube position being verified by MRI. After a baseline MRI scan, each volunteer had eight 40 ml boluses of a non-absorbable mannitol and saline solution infused into their proximal small bowel with an MRI scan being acquired after each bolus. The MRI sequence used was an adapted magnetic resonance cholangiopancreatography sequence. The image data were thresholded to allow for intra- and inter-subject signal variations. The MRI measured volumes were then compared to the known infused volumes. This MRI technique gave excellent images of the small bowel, which closely resemble those obtained using conventional radiology with barium contrast. The mean difference between the measured MRI volumes and infused volumes was 2% with a standard deviation of 10%. The maximum 95% limits of agreement between observers were -15% to +17% while measurements by the same operator on separate occasions differed by only 4%. This new technique can now be applied to study alterations in small bowel fluid absorption and secretion due to gastrointestinal disease or drug intervention.

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Section: Intubation and Mr Imagingmentioning

confidence: 99%

Non-invasive quantification of small bowel water content by MRI: a validation study

Hoad¹,

Marciani²,

Foley³

et al. 2007

Phys. Med. Biol.

118

View full text Add to dashboard Cite

show abstract

“…This sequence yields high-intensity signals from areas with non-viscous ('free') fluid and little signal from body tissues 45 (Figure 1A). This sequence and analysis method to measure the volume of small bowel 'free' water has been validated using an infusion of known amounts of a mannitol-saline solution, known from perfusion studies to show no net absorption or secretion 46 . The mannitol-saline solution was instilled (via a nasoduodenal tube) in boluses of 40ml up to a total of 320 ml and the resulting images used to assess the volume.…”

Section: Measuring Small Bowel Water Contentmentioning

confidence: 99%

Enhancing our understanding of small bowel function using modern imaging techniques

Spiller

Hoad

2019

Neurogastroenterology Motil

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Small intestinal function is critical to digestive health and patients believe an abnormal reaction to food is responsible for many of their symptoms. Despite this, our ability to assess disturbed function in clinical practice has been limited, particularly after ingestion of the complex nutrients which make up normal food. Recent advances in both wireless capsules and magnetic resonance imaging have provided new insights. This review will briefly describe the limitations of past techniques and focus on how these newer techniques are changing our understanding, particularly of how patients' gastrointestinal tracts respond to food.

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“…After excluding the gall bladder and stomach, and thresholding based on the cerebral spinal fluid to exclude background noise, an area of bowel occupied by water can be calculated and summed across the different slices to calculate a volume. We have evaluated this by using a duodenal infusion of a balanced mannitol saline solution, which showed no net absorption or secretion during jejunal perfusion . Twelve subjects received boluses of mannitol saline, and the infused volume showed an excellent correlation with the measured small bowel water content with the 95% limits of agreement between −16% and 22%.…”

Section: Introductionmentioning

confidence: 99%

How do FODMAPs work?

Spiller

2017

J of Gastro and Hepatol

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Disclosures: RS has received research funding from Lesaffre and Ironwood. He has also acted on advisory boards for Allergan, Commonwealth Diagnostics International, Danone, Ipsen, and Yuhan, and received speakers' fees from Menarini. AbstractMany patients report symptoms come on after eating, and experience with exclusion diets suggests that certainly poorly absorbed but rapidly fermentable carbohydrates may be responsible. While monomeric and short chain carbohydrate polymers exert osmotic forces and trap water in the small bowel with acceleration of transit, the longer polymer polymers such as inulin pass through the small bowel unaltered but are fermented in the colon where they may cause distension and symptoms. Recent developments in magnetic resonance imaging confirm the importance of fructose in stimulating small bowel water secretion and its negation by the presence of glucose. Fructans have no impact on the small intestine but cause colonic distension and symptoms including bloating.

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Inhibition of Jejunal Water and Electrolyte Absorption by Therapeutic Doses of Clindamycin in Man

Cited by 6 publications

References 0 publications

Non-invasive quantification of small bowel water content by MRI: a validation study

Non-invasive quantification of small bowel water content by MRI: a validation study

Enhancing our understanding of small bowel function using modern imaging techniques

How do FODMAPs work?

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