Inhibition of intimal hyperplasia via local delivery of vascular endothelial growth factor cDNA nanoparticles in a rabbit model of restenosis induced by abdominal aorta balloon injury

Xie, Hongzhi; Yang, Jing; Yao, Han; Zhu, Xiangyang; Fang, Quan

doi:10.3892/etm.2015.2438

Cited by 8 publications

(21 citation statements)

References 37 publications

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“…Our findings revealed that the levels of EPC, SDF‐1α, VEGF, and NO were decreased greatly in the elderly patients with multivessel reocclusions compared to the elderly patients with one‐ or two‐vessel reocclusions. Oxidative stress responses and inflammatory responses decreased the overexpressions of EPC, SDF‐1α, VEGF, and NO, and the reduced circulating EPC, SDF‐1α, VEGF, and NO led to coronary in‐stent restenosis . The present study suggested that the decreased levels of EPC, SDF‐1α, VEGF, and NO were related to coronary in‐stent reocclusion and severity of reocclusion after coronary stenting and may be considered as the important targets for treatment in a new stent design for interventional therapy of coronary artery stenoses.…”

Section: Discussionmentioning

confidence: 51%

“…The research suggested that the efficacy of using VEGF gene in the treatment of coronary in‐stent restenosis following coronary artery injury. The VEGF induced endothelialization and decreased coronary artery intimal thickening, multiplication of foam cells, and coronary in‐stent restenosis . The VEGF levels were decreased greatly in the patients with CHD and predicted the worse clinical outcome in the patients with CHD after coronary stenting, and VEGF was considered as a promising predictive biomarker in CHD .…”

Section: Discussionmentioning

confidence: 98%

“…The VEGF induced endothelialization and decreased coronary artery intimal thickening, multiplication of foam cells, and coronary instent restenosis. 9 The VEGF levels were decreased greatly in the patients with CHD and predicted the worse clinical outcome in the patients with CHD after coronary stenting, and VEGF was considered as a promising predictive biomarker in CHD. 11 The studies demonstrated the VEGF reduced coronary in-stent restenosis and the coronary stents coated with VEGF and intracoronary injection of VEGF gene were the promising methods for the prevention and therapy of coronary in-stent restenosis.…”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory response was the mechanism of in‐stent restenosis after coronary stenting in the patients with myocardial infarction and VEGF had a key role in inhibiting coronary in‐stent restenosis. The research showed that the local transfer of VEGF gene decreased intimal thickening and cell proliferation and restenosis of the coronary arteries after balloon and stent damages . VEGF gene expressions were remarkably decreased in the patients with CHD and high doses of VEGF were considered as a therapeutic agent for improving myocardial function and symptoms of angina .…”

Section: Introductionmentioning

confidence: 99%

“…The research showed that the local transfer of VEGF gene decreased intimal thickening and cell proliferation and restenosis of the coronary arteries after balloon and stent damages. 9 VEGF gene expressions were remarkably decreased in the patients with CHD and high doses of VEGF were considered as a therapeutic agent for improving myocardial function and symptoms of angina. 10 The results showed that VEGF expressions can serve as a predictive biomarker of coronary restenosis and the reduced level of VEGF also predicted worse clinical outcome in the patients with CHD after coronary stenting.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stenting

Zhou

Guo

et al. 2020

IUBMB Life

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Pro‐inflammatory responses and oxidative stress damages, and effects of the reduced anti‐oxidation and anti‐inflammation were involved in development and progression of coronary heart disease. We tried to identify the effects of pro‐inflammatory and oxidative stress biomarkers as well as anti‐oxidant and anti‐inflammatory factors on multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stenting. We determined the expression levels of endothelial progenitor cell (EPC), stromal cell‐derived factor‐1α (SDF‐1α), vascular endothelial growth factor (VEGF), nitric oxide (NO), toll‐like receptor 2 (TLR2), toll‐like receptor 3 (TLR3), toll‐like receptor 4 (TLR4), and soluble ST2 (sST2) in elderly patients with multiple recurrent coronary in‐stent chronic total occlusions after coronary stenting. The levels of EPC, SDF‐1α, VEGF, and NO were decreased in elderly patients with multiple recurrent coronary in‐stent chronic total occlusions (p < .001). The levels of TLR2, TLR3, TLR4, and sST2 were increased in elderly patients with multiple recurrent coronary in‐stent chronic total occlusions (p < .001). The oxidative stress damages and pro‐inflammatory responses played the crucial roles in multiple recurrent coronary in‐stent chronic total occlusions of elderly patients after coronary stent placement. The levels of TLR2, TLR3, TLR4, and sST2, and the expressions of EPC, SDF‐1α, VEGF, and NO could be considered as potential early predictive indicators for multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stent implantation.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stenting

Zhou

Guo

et al. 2020

IUBMB Life

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Design and Fabrication of Environmentally Responsive Nanoparticles for the Diagnosis and Treatment of Atherosclerosis

Wang,

Lu,

Yin

et al. 2024

ACS Biomater. Sci. Eng.

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Cardiovascular disease poses a significant threat to human health in today's society. A major contributor to cardiovascular disease is atherosclerosis (AS). The development of plaque in the affected areas involves a complex pathological environment, and the disease progresses rapidly. Nanotechnology, combined with emerging diagnostic and treatment methods, offers the potential for the management of this condition. This paper presents the latest advancements in environment-intelligent responsive controlled-release nanoparticles designed specifically for the pathological environment of AS, which includes characteristics such as low pH, high reactive oxygen species levels, high shear stress, and multienzymes. Additionally, the paper summarizes the applications and features of nanotechnology in interventional therapy for AS, including percutaneous transluminal coronary angioplasty and drug-eluting stents. Furthermore, the application of nanotechnology in the diagnosis of AS shows promising real-time, accurate, and continuous effects. Lastly, the paper explores the future prospects of nanotechnology, highlighting the tremendous potential in the diagnosis and treatment of atherosclerotic diseases, especially with the ongoing development in nano gas, quantum dots, and Metal−Organic Frameworks materials.

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Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

Liu

2022

Sig Transduct Target Ther

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Aging-induced alternations of vasculature structures, phenotypes, and functions are key in the occurrence and development of vascular aging-related diseases. Multiple molecular and cellular events, such as oxidative stress, mitochondrial dysfunction, vascular inflammation, cellular senescence, and epigenetic alterations are highly associated with vascular aging physiopathology. Advances in nanoparticles and nanotechnology, which can realize sensitive diagnostic modalities, efficient medical treatment, and better prognosis as well as less adverse effects on non-target tissues, provide an amazing window in the field of vascular aging and related diseases. Throughout this review, we presented current knowledge on classification of nanoparticles and the relationship between vascular aging and related diseases. Importantly, we comprehensively summarized the potential of nanoparticles-based diagnostic and therapeutic techniques in vascular aging and related diseases, including cardiovascular diseases, cerebrovascular diseases, as well as chronic kidney diseases, and discussed the advantages and limitations of their clinical applications.

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Inhibition of intimal hyperplasia via local delivery of vascular endothelial growth factor cDNA nanoparticles in a rabbit model of restenosis induced by abdominal aorta balloon injury

Abstract: Abstract. In-stent restenosis (ISR) is one of the major factors affecting long-term outcomes of percutaneous coronary interventions.

Cited by 8 publications

References 37 publications

Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stenting

Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in‐stent chronic total occlusions in elderly patients after coronary stenting

Design and Fabrication of Environmentally Responsive Nanoparticles for the Diagnosis and Treatment of Atherosclerosis

Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

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