Inhibition of intestinal lipases alleviates the adverse effects caused by high-fat diet in Nile tilapia

Zhang, Yuxue; Jiang, Zhe-Yue; Han, Si-Lan; Li, Lingyu; Qiao, Fang; Zhang, Meiling; Du, Zhen‐Yu

doi:10.1007/s10695-019-00701-x

Cited by 19 publications

(11 citation statements)

References 56 publications

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“…That suggested proper lipid level in diets promoted hepatic lipid utilization by increasing TL activities, while excess lipid level caused abundant lipid deposition and metabolic disturbance in liver to the decrease of TL activities. ILPS activities can reflect the ability of intestinal lipid absorption (Zhang et al, 2020). In this study, ILPS activities in D2 and D3 groups were significantly higher than those in other groups, which indicated moderate lipid level improved lipid utilization in the intestine.…”

Section: Analysis Of the Differences In Intestinal Microbiotamentioning

confidence: 51%

Effects of dietary lipid levels on growth performance, plasma biochemistry, lipid metabolism and intestinal microbiota of juvenile golden pompano ( Trachinotus ovatus )

et al. 2021

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Section: Analysis Of the Differences In Intestinal Microbiotamentioning

confidence: 51%

Effects of dietary lipid levels on growth performance, plasma biochemistry, lipid metabolism and intestinal microbiota of juvenile golden pompano ( Trachinotus ovatus )

et al. 2021

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“…During recent years, HFD is also widely used in tilapia aquaculture, and the adverse effects in disturbing metabolism had also been reported (Liu et al., 2018). Our previous study had indicated that HFD (more than 120 g/kg fat) could cause severe fat accumulation compared with medium fat diet (70 g/kg fat) in Nile tilapia (He et al., 2015; Zhang et al., 2020). Therefore, in order to determine the possible regulatory effects of TP on flesh quality in the HFD‐fed GIFT tilapia, in the present experiment, the GIFT tilapias were fed with control diet (60 g/kg fat), HFD (120 g/kg fat) and the HFD supplemented with two doses of TP (50 mg/kg and 200 mg/kg, respectively) for 8 weeks.…”

Section: Introductionmentioning

confidence: 99%

Dietary tea polyphenols change flesh quality with dose‐related manner in the GIFT tilapia fed with a high‐fat diet

Wang

Qian

et al. 2020

Aquacult. Nutr.

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In aquaculture, the wide use of high-fat diet (HFD) could save protein and reduce feed costs, but also cause lipid deposition and impair flesh quality in fish. We hypothesized that tea polyphenols (TP) could alleviate the adverse effects of HFD on flesh quality in fish; thus, in the present study, GIFT tilapias were fed with control diet (60 g/kg fat), HFD (120 g/kg fat) and the HFD supplemented with two doses of TP (50 and 200 mg/kg, respectively) for 8 weeks. As compared with the control,

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“…This reversal of increased intestinal permeability in the HFDO- and HFDM-treated groups is reflected by the lower FITC-dextran intensity observed in the serum of the HFDO and HFDM groups ( Figure 14 B). Recently, Zhang et al reported that Orlistat prevented gut barrier disruption in HFD-fed Nile tilapia by upregulating the expression of Claudin-3, a tight junction protein [ 35 ]. We also measured the expression levels of Nesfatin-1, a potent anti-obesity and anti-inflammatory peptide, in the jejunum.…”

Section: Discussionmentioning

confidence: 99%

Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice

et al. 2020

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Obesity and hyper-intestinal permeability are interconnected. This study is designed to evaluate the ability of Mangifera indica seed kernel extract (MESK) in restoring the intestinal barrier and preventing obesity and associated metabolic complications in a high-fat diet-induced obese mouse model. Four groups of Swiss albino mice: (1) normal diet (ND), (2) high-fat diet (HFD), (3) HFD + Orlistat (100 µg/kg), and (4) HFD + MESK (75 µg/kg), were used to monitor various biochemical parameters associated with metabolic syndrome (glucose, total cholesterol, triglycerides) and body weight in an eight-week-long study. In vivo intestinal permeability was determined by the FITC-dextran method. Interestingly, MESK significantly reduced HFD-induced body weight gain, hepatic lipid accumulation, hepatic fibrosis, hyperglycemia, and dyslipidemia. Additionally, MESK treatment restored the expression of tight junction protein Zonula Occludens-1 (ZO-1) and Claudin-1 and hence prevented increased intestinal permeability induced by a high-fat diet. Moreover, it also increased the expression of potent satiety molecule Nesfatin-1 in the mouse jejunum. Our results, for the first time, establish MESK as a nutraceutical which prevents disruption of the intestinal barrier and thereby intercepts the adverse consequences of compromised intestinal permeability such as obesity, hyperglycemia, dyslipidemia, and systemic inflammation.

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Inhibition of intestinal lipases alleviates the adverse effects caused by high-fat diet in Nile tilapia

Cited by 19 publications

References 56 publications

Effects of dietary lipid levels on growth performance, plasma biochemistry, lipid metabolism and intestinal microbiota of juvenile golden pompano ( Trachinotus ovatus )

Effects of dietary lipid levels on growth performance, plasma biochemistry, lipid metabolism and intestinal microbiota of juvenile golden pompano ( Trachinotus ovatus )

Dietary tea polyphenols change flesh quality with dose‐related manner in the GIFT tilapia fed with a high‐fat diet

Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice

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