Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia

Baldea, Lidia A. Nistor; Martineau, Louis C.; Benhaddou-Andaloussi, Ali; Arnason, John T.; Lévy, Émile; Haddad, Pierre S.

doi:10.1016/j.jep.2010.07.055

Cited by 59 publications

(19 citation statements)

References 51 publications

(84 reference statements)

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“…In the management of T2D, the primary factor to control is the postprandial blood glucose level. In addition to their antioxidant effects, dietary polyphenols have been shown to exert antihyperglycemic effects by competitive inhibition of digestive enzymes and binding to glucose transporters [27,28]. α-Amylase and α-glucosidase are carbohydrate hydrolyzing enzymes responsible for dietary starch digestion and oligosaccharides degradation to glucose, resulting in postprandial glucose increase.…”

Section: Antidiabetic Activity In Vitromentioning

confidence: 99%

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

et al. 2020

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This study evaluated the potential antioxidant and antidiabetic properties in vitro of four millet grain varieties cultivated in South Korea. The free fractions were tested for their total antioxidant capacity using 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+) and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, followed by α-glucosidase, α-amylase, and advanced glycation endproducts (AGEs) formation inhibition assays. The total phenolics, flavonoids, and condensed tannins in the free fractions ranged from 107.8 to 136.4 mg ferulic acid equivalent (FAE)/100 g, 101.3 to 115.8 mg catechin equivalent (CE)/100 g, and 17.65 to 59.54 mg catechin equivalent (CE)/100 g, respectively. Finger Italian millet had the highest total phenolic content (136.4 mg FAE/100 g) and flavonoid content (115.8 mg CE/100 g). Barnyard and finger Italian millet showed the highest DPPH (IC50 = 359.6 µg/mL and 436.25 µg/mL, respectively) and ABTS radical scavenging activity (IC50 = 362.40 µg/mL and 381.65 µg/mL, respectively). Similarly, finger Italian millet also exhibited significantly lower IC50 values for the percentage inhibition of α-glucosidase (18.07 µg/mL) and α-amylase (10.56 µg/mL) as compared with acarbose (IC50 = 59.34 µg/mL and 27.73 µg/mL, respectively) and AGEs formation (33.68 µg/mL) as compared with aminoguanidine (AG) (52.30 µg/mL). All eight phenolic compounds identified in finger Italian millet were flavonoids, with flavanols being the predominant subclass. Taken together, millet flavonoids play important roles in the prevention and management of type 2 diabetes, and hence finger Italian millet has the potential to be developed as a functional food.

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Section: Antidiabetic Activity In Vitromentioning

confidence: 99%

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

et al. 2020

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“…: yet undetermined. The data that forms the basis of this table has been collated from several studies that have already been published by our team [73–75, 91, 94, 95, 104, 108, 117, 119, 120] as well as data (especially from in vivo studies) that have not yet been published (several currently under review). The names of plants must thus remain undisclosed to protect both the traditional knowledge shared by Cree Elders and the unpublished data.…”

Section: Figurementioning

confidence: 99%

Comprehensive Evidence-Based Assessment and Prioritization of Potential Antidiabetic Medicinal Plants: A Case Study from Canadian Eastern James Bay Cree Traditional Medicine

Haddad

Musallam

Martineau

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary (glucose-lowering) and secondary (toxicity, drug interactions, complications) antidiabetic activity by using a comprehensive platform of in vitro cell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. These in vitro and in vivo findings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide.

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“…It is well known that carbohydrates in the diet are hydrolyzed into monosaccharides, and then absorbed through the intestine by a transepithelial transport system. A number of studies have reported that glucose absorption increases following enhanced activity, mRNA, and protein levels of intestinal SGLT1, Na + /K + -ATPase and GLUT2 in the brush border membrane (BBM) and basolateral membrane (BLM) of STZ-induced diabetic animals [3]–[6]. Sustained supra-physiological glucose level resulting from excessive glucose assimilation may be toxic to β-cells, leading to deterioration of insulin control [7].…”

Section: Introductionmentioning

confidence: 99%

Cooperative Anti-Diabetic Effects of Deoxynojirimycin-Polysaccharide by Inhibiting Glucose Absorption and Modulating Glucose Metabolism in Streptozotocin-Induced Diabetic Mice

et al. 2013

PLoS ONE

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We had previously shown that deoxynojirimycin-polysaccharide mixture (DPM) not only decreased blood glucose but also reversed the damage to pancreatic β-cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or polysachharide alone. However, the mechanisms behind these effects were not fully understood. The present study aimed to evaluate the therapeutic effects of DPM on streptozotocin (STZ)-induced diabetic symptoms and their potential mechanisms. Diabetic mice were treated with DPM (150 mg/kg body weight) for 90 days and continued to be fed without DPM for an additional 30 days. Strikingly, decrease of blood glucose levels was observed in all DPM treated diabetic mice, which persisted 30 days after cessation of DPM administration. Significant decrease of glycosylated hemoglobin and hepatic pyruvate concentrations, along with marked increase of serum insulin and hepatic glycogen levels were detected in DPM treated diabetic mice. Results of a labeled 13C6-glucose uptake assay indicated that DPM can restrain glucose absorption. Additionally, DPM down-regulated the mRNA and protein expression of jejunal Na+/glucose cotransporter, Na+/K+-ATPase and glucose transporter 2, and enhanced the activities as well as mRNA and protein levels of hepatic glycolysis enzymes (glucokinase, phosphofructokinase, private kinase and pyruvate decarboxylas E1). Activity and expression of hepatic gluconeogenesis enzymes (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) were also found to be attenuated in diabetic mice treated with DPM. Purified enzyme activity assays verified that the increased activities of glucose glycolysis enzymes resulted not from their direct activation, but from the relative increase in protein expression. Importantly, our histopathological observations support the results of our biochemical analyses and validate the protective effects of DPM on STZ-induced damage to the pancreas. Thus, DPM has significant potential as a therapeutic agent against diabetes.

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Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia

Cited by 59 publications

References 51 publications

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

Comprehensive Evidence-Based Assessment and Prioritization of Potential Antidiabetic Medicinal Plants: A Case Study from Canadian Eastern James Bay Cree Traditional Medicine

Cooperative Anti-Diabetic Effects of Deoxynojirimycin-Polysaccharide by Inhibiting Glucose Absorption and Modulating Glucose Metabolism in Streptozotocin-Induced Diabetic Mice

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