Inhibition of intestinal alkaline phosphatase by palladium

Liu, Tsan Z.; Chou, Li-Shan; Humphreys, Michael H.

doi:10.1016/0378-4274(79)90108-5

Cited by 13 publications

(2 citation statements)

References 8 publications

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“…It appears that palladium inhibits enzymes by binding with SH groups (29), or by substituting Fe 2+ (57). Also, available data indicate that palladium inhibits some other cell enzymes: lactate de hydrogenase (LDH) (58), alkaline phosphatase (30,59), aldolase, carbonic anhydrase (30), etc. These cytotoxic effects of the palladium ion could explain the de pressant effect of palladium compounds on the heart.…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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SummaryPrevious studies have shown that palladium has toxic effects on the kidney and liver, leads to deterioration of the general condition of animals, and could cause allergy in animals and humans. Considering the limited data about the influence of palladium on the cardiovascular system, the aim of our study was to evaluate the effects of palladium on the heart from available published data, and to compare the toxicity of inorganic and organic palladium compounds. Relevant studies for our review were identified from PubMed and Scopus databases. The search terms included »palladium «, »palladium compound«, »cardiotoxicity«, »toxicity«, »heart«, »myocardium«, »oxidative stress« and »myocardial enzyme«, as well as combinations of these terms. There were only two published studies with the primary purpose to investigate the effect of palladium on the cardiovascular system, while others registered the side-effects of palladium compounds on the heart. Palladium could cause arrhythmias, a drop in blood pressure, decrease of the heart rate, as well as death of experimental animals. Based on the presented data it seems that palladium does not express significant cardiac toxicity when it is bound in an organic compound. Further investigation of the effects of palladium on the heart is necessary for a clear picture of the nature and extent of its cardiac toxicity.

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Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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“…Механизам инхибиције овог ензима могао би бити замена Fe 2+ јоном Pd 2+ и стварање чврстог комплекса једињења 229. Такође, сматра се да овај катјон ствара чврст комплекс са -SH групама креатин киназе,140 и да на тај начин LDH),242 алкалне фосфатазе,141,175 карбон анхидразе, сукцинат дехидрогеназе, пролил хидроксилазе и алдолазе,141 рибонуклеазе 249. PdSO 4 инхибира пролил хидроксилазу,229 Pd(NO 3 ) 2 инхибира аминопирин деметилазу,43 а K 2 PdCl 6 рибонуклеазу 249.…”

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Efekti jedinjenja paladijuma na kontraktilnost, koronarni protok i vijabilnost izolovanog srca pacova

Peric¹

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Palladium und seine Verbindungen [MAK Value Documentation in German language, 1981]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 8. Lieferung, Ausgabe 1981 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Chronische und subchronische Toxizität Untersuchungen zu sensibilisierenden und allergisierenden Eigenschaften von Palladiumverbindungen Carcinogenitätsversuch Zur Frage eines MAK‐Wertes

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Inhibition of intestinal alkaline phosphatase by palladium

Cited by 13 publications

References 8 publications

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Efekti jedinjenja paladijuma na kontraktilnost, koronarni protok i vijabilnost izolovanog srca pacova

Palladium und seine Verbindungen [MAK Value Documentation in German language, 1981]

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