Inhibition of Insulin Release by Endogeneous Insulin in Vitro

High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets

“…Previous studies indicated that insulin inhibits its own glucose-stimulated secretion when a static incubation system is used 51,52 . The extent of inhibition seems to be related to the number of islets incubated 53 . In contrast, islets that were loaded into a dynamic perifusion system do not show a secretory downregulation through ambient insulin 54 even when seeded at a density of 4,000 islets per cm 2(55) .…”

Diurnal Change of Plasma Insulin, Free Fatty Acids and Human Growth Hormone in Diabetics during Bonito Insulin Treatment

“…Grodsky and his co-workers (1968) found no suppressive effect of the bonito insulin on the insulin secretion from rat pancreas. However, an inhibition of the insulin release from the pancreas by insulin in vitro was demonstrated by Sodoyez et al (1969), Hahn and Michael (1970), and Iversen (1971). Since in our study the plasma insulin area increased by the treatment with bonito insulin, it seems unlikely that bonito insulin euppresses the secretion of insulin from the pancreas.…”

Metabolic and Hormonal Responses during a Glucose Contrlled Insulin Infusion (Biostator®) in Subjects with Imparied Glucose Tolerance1)

“…The possibility of feed-back inhibiton of insulin secretion by insulin itself has been the subjects of considerable controversy (Schatz and Pfeiffer, 1977;Hahn and Michael, 1970;Liljenquist et al, 1978;Shima et al, 1977;Zilker et al, 1977;Beischer et al, 1978;Tanaka et al, 1980). Glucose-induced endogenous insulin secretion was significantly reduced during the glucose-controlled insulin infusion by means of the Biostator.…”