Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane

Sekine, Kazunori; Ushida, Yoshihiko; Kuhara, Tetsuya; Iigo, Masaaki; Baba-Toriyama, Hiroyasu; Moore, Malcolm A; Murakoshi, Michiaki; Satomi, Yoshiko; Nishino, Hoyoku; Kakizoe, Tadao; Tsuda, Hiroyuki

doi:10.1016/s0304-3835(97)00358-3

Cited by 78 publications

(51 citation statements)

References 17 publications

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“…The protective activity of lactoferrin against chemically induced rat tumours is consistent with results obtained using preparations of proteins from whey and other dairy products (Abdelali et al, 1995). Thus, even if lactoferrin should be confirmed to be a milk component with cancer -chemopreventive properties, the effect of lactoferrin would probably be limited for most dairy products because of its low natural concentration (0.02% in cows' milk) and its destruction by heat treatments used for milk conservation (Sekine et al, 1997). The lack of clinical and epidemiological data in humans precludes any firm conclusion on a specific effect of milk proteins in carcinogenesis.…”

Section: Lactic Acid Bacteriasupporting

confidence: 79%

“…Lactoferrin may have other protective functions, by activating NK cells and stimulating lymphokine-activated killer (LAK) cells (Shau et al, 1992;Sekine et al, 1997). Human lactoferrin may inhibit the development of solid tumours of the colon and of metastases from a melanoma cell line in mice (Bezault et al, 1994;Yoo et al, 1997) and may reduce significantly the incidence and number of adenocarcinomas of the large intestine in rats (Sekine et al, 1997). The protective activity of lactoferrin against chemically induced rat tumours is consistent with results obtained using preparations of proteins from whey and other dairy products (Abdelali et al, 1995).…”

Section: Lactic Acid Bacteriamentioning

confidence: 99%

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Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003

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Objectives: This review provides an overview of the principal hypotheses and epidemiological evidence of the possible links between colorectal cancer and intake of milk and=or dairy products. Methods: The first section outlines the main hypotheses about the possible effect of calcium, vitamin D, fats and other milk components. The possible role of acid lactic bateria in fermented products is also discussed. The second section is a summary of the published epidemiological evidence. The results on milk, cheese and yoghurt are summarized using a meta-analytical approach. The results of studies on calcium and vitamin D are briefly described. Results: Case -control studies are heterogeneous and, on average, do not provide evidence of association between total intake of total dairy products, milk, cheese or yoghurt and colorectal cancer risk. The average result from cohort studies support the hypothesis of a protective effect of total dairy products (odds ratio (OR): 0.62; 95% confidence interval (CI): 0.52 -0.74; P heterogeneity test: 0.93) and for milk (OR: 0.80; 95% CI: 0.68 -0.95; P heterogeneity: 0.77). No association was found between cheese (OR: 1.10; 95% CI: 0.88 -1.36; P heterogeneity: 0.55) or yoghurt (OR: 1.03; 95% CI: 0.83 -1.28; P heterogeneity: 0.69) in cohort studies. Conclusions: Cohort studies consistently found a protective effect of total dairy products and milk intake, but the evidence is not supported by case -control studies. No relationship was found with cheese or yoghurt intake. As the number of cohort studies is still limited, their results need to be confirmed by other prospective studies.

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Section: Lactic Acid Bacteriasupporting

confidence: 79%

Section: Lactic Acid Bacteriamentioning

confidence: 99%

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003

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“…Further examination is necessary of the influence of LF feeding on immunological events in the oral tissue using this model. In the past few years, several immunomodulatory effects of ingested LF in animals have been reported (Sekine et al, 1997;Wakabayashi et al, 2002). Very recently, we showed that LF feeding augmented macrophage activity at the local site where inactivated Candida was injected as a priming agent (Wakabayashi et al, 2003).…”

Section: Kinetics Of Numbers Of Pbl and Cln Cellsmentioning

confidence: 92%

Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model

Takakura

Wakabayashi

Ishibashi

et al. 2004

Journal of Medical Microbiology

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“…We have recently shown that dietary supplementation with bovine lactoferrin (bLF), derived from bovine milk, 2) can inhibit the development of azoxymethane (AOM)-induced aberrant crypt foci (ACF) as precursor lesions of tumor development, 9) as well as carcinomas 10) in the rat colon, without any toxic effects in major organs. It was also found to reduce growth and metastasis of solid tumors.…”

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confidence: 99%

Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat

Ushida

Sekine

Kuhara

et al. 1999

Japanese Journal of Cancer Research

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A milk component, bovine lactoferrin (bLF), previously shown by us to be a strong chemopreventive of colon carcinoma development, was examined for its influence on other organs using a rat multi-organ carcinogenesis model. Male F344 rats, aged 6 weeks, were treated sequentially with diethylnitrosamine (DEN, i.p.), dihydroxy-di-N-propylnitrosamine (DHPN, in drinking water) and N-nitrosomethylbenzylamine (NMBA, s.c.) during the first 8 weeks (DDN treatment), and then bLF was administered in the basal diet, at a dose of 2, 0.2, 0.02 or 0.002%. Other groups were given DDN treatment or bLF alone as controls. All surviving animals were killed at week 41, and major organs were examined histopathologically for neoplastic lesions. In the esophagus, a tendency for reduction in development of papillomas was evident in the bLF-treated animals, along with a significant suppression of relatively large-sized papillomas (more than 50 mm 3 volume) at the 0.2% dose (P< < < <0.05, 11% of the control). The multiplicity of tumors (adenomas and carcinomas) in the lung was also decreased in animals fed 0.02% bLF (1.98± ± ± ±0.41 per cm 2 lung tissue section, P< < < <0.05) compared to the control group (3.48± ± ± ±0.33). No enhancing or inhibitory effects of bLF on tumor development in other organs were noted. The present results indicate that bLF exerts chemopreventive effects in the esophagus and lung in addition to the colon.

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Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane

Cited by 78 publications

References 17 publications

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model

Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat

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