Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids.

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

“…The structural components common to these molecules include two benzene rings on either side of a 3-carbon ring. Figure 5) isolated from the roots of Scutellaria baicalensis, was shown to have a specific inhibitory activity against influenza virus NA because it did not affect the mouse liver NA activity [84,85]. F36 inhibited the proliferation of influenza virus in MDCK cells, in the allantoic sac of embryonal chicken egg and in vivo using BALB/c mice [85][86][87].…”

“…Figure 5) isolated from the roots of Scutellaria baicalensis, was shown to have a specific inhibitory activity against influenza virus NA because it did not affect the mouse liver NA activity [84,85]. F36 inhibited the proliferation of influenza virus in MDCK cells, in the allantoic sac of embryonal chicken egg and in vivo using BALB/c mice [85][86][87]. Immunoelectron microscopic analysis revealed that F36 inhibited the budding of progeny influenza virus particles from MDCK cell surface and microvilli [88].…”

Antiviral Activity of a Hot Water Extract of Black Soybean against a Human Respiratory Illness Virus

“…However, the absorption spectrum of the partialy puriˆed antiviral active fragment obtained by ion-exchange HPLC showed a maximum absorbance at 260 nm, suggesting that the antiviral compound may have contained the phenyl group(s). Although some antiviral compounds having aromatic groups (synthetic antiviral agents 22,23) and polyphenolic compounds [24][25][26][27] isolated from natural products) have been reported, the molecular masses of these compounds are less than 1 kDa. Therefore, the antiviral compound(s) from black soybean would have been diŠerent from these well-known aromatic antiviral compounds.…”

Inhibitory Effects of Goishi Tea against Influenza Virus Infection

“…Furthermore, it has been determined that theaflavins such as flavan-3-ol in black tea have the ability to inactivate both rotavirus and coronavirus in an in vitro test and inhibit the infectivity of both influenza A virus and influenza B virus in Mardin-Darby canine kidney (MDCK) cells (Clark et al, 1998;Nakayama et al, 1993). In addition, it has been reported that flavonoids, 5,7,4´-trihydroxy-8-methoxyflavone, and tannic acid in some plants inactivate Flu, too (Carson et al, 1953;Miki et al, 2007;Nagai et al, 1990;Nagai et al, 1995).…”