Inhibition of In Vivo Tumor Angiogenesis and Growth Via Systemic Delivery of an Angiopoietin 2-Specific RNA Aptamer

Sarraf-Yazdi, Shiva; Mi, Jing; Moeller, Benjamin J.; Niu, Xi-Lin; White, Rebekah R.; Kontos, Christopher D.; Sullenger, Bruce A.; Dewhirst, Mark W.; Clary, Bryan M.

doi:10.1016/j.jss.2007.04.028

Cited by 49 publications

(38 citation statements)

References 40 publications

(61 reference statements)

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“…The expression levels in Stages C and D were significantly higher than those in Stages A and B, and the expression levels in those with lymphatic metastasis were significantly higher than those without lymphatic metastasis. All of the above results were consistent with DOI:http://dx.doi.org/10.7314/APJCP.2014.15.20.8651 Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer and its Significance existing literature (Wang et al, 2007;Cao et al, 2007;Sarraf-Yazdi et al, 2008). The results suggested that overexpression of Ang-2 could facilitate the metastasis of colorectal cancer and influence its development and prognosis.…”

Section: Discussionsupporting

confidence: 89%

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Zhang

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 89%

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Zhang

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Some cytokines (IL-1a, 2, 3, 4, 5, 6, 9, eotaxin, MIP-1a and GM-CSF) were not detected or were not significantly altered by a liver tumor burden. The serum concentrations of a group of cytokines (IL-1b, 10, 12 (p70), 13,15,17,18, MIP-1b, INF-c and TNF-a) were decreased after liver colony formation in Ang2 À/À mice. There were only slight changes in the concentration of these cytokines in the wild type mice after colony formation (left plot, Fig.…”

Section: Association Of G-csf and Neutrophils In Liver Colonization Omentioning

confidence: 98%

“…Considering many previous reports showing tumor growth inhibition by Ang2 suppression, this increase of tumor cells in the liver was striking. 13,15 We also followed liver colony growth using magnetic resonance imaging (MRI). At 9 days after the IS injection, we could reliably detect colonies in both genotypes.…”

Section: Tumor Growth In the Livermentioning

confidence: 99%

“…12 To ask about the effects of inhibition of Ang2, compounds that inhibit or trap Ang2 (and may also trap Ang1) including a soluble Tie2 receptor, antibody trapping and anti Ang2 specific antibody have been used. [13][14][15][16] In general, these methods led to reduced tumor growth and decreased endothelial proliferation suggesting that Ang2 has a pro-angiogenic role in tumors and could be a useful therapeutic target. Aptamers to Ang2 also reduced tumor growth but this agent at high dose caused enhancement of angiogenesis.…”

mentioning

confidence: 99%

“…Aptamers to Ang2 also reduced tumor growth but this agent at high dose caused enhancement of angiogenesis. 13 Intracranial injection of glioma cell lines led to initial increases in Ang2 expression that were accompanied by vascular regression. 7 However, this was only a transient phase with subsequent hypoxia potentially triggered by renewed angiogenesis.…”

mentioning

confidence: 99%

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G‐CSF rescues tumor growth and neo‐angiogenesis during liver metastasis under host angiopoietin‐2 deficiency

Im¹,

Tapmeier²,

Balathasan³

et al. 2012

Intl Journal of Cancer

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Suppression of neo‐angiogenesis is a clinically used anti‐tumor strategy with new targets such as angiopoietin‐2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang2−/−) mice. Surprisingly, the metastatic colonies formed in Ang2−/− mice were larger than those in the wild type. These colonies had greater vascular density with more pericyte coverage than the vessels in liver colonies in the wild type. Liver VEGF concentration in both genotypes was equivalent, and thus, the differences appeared VEGF independent. However, after colony formation, the serum concentration of granulocyte‐colony stimulating factor (G‐CSF) and CXCL1 in Ang2−/− mice was 12 and 6 times greater than after colony formation in wild type. Increase of these two cytokines was associated with two times greater numbers of neutrophils recruited to the liver. Two times more Tie2+/CD11b+/CD31− cells were present in the tumors in Ang2−/− than in the wild type livers. These results suggest that the depletion of host Ang2 induced compensatory VEGF‐independent angiogenic mechanisms and thus enhanced liver metastatic colony growth and colony vascularity. They further indicate organotypic differences in response to tumor metastasis. In contrast, Ang2 deficiency inhibited tumor growth during metastatic colony formation in the lung, consistent with the reports of decreased pulmonary seeding of tumor cells after pharmacological inhibition of Ang2. Further studies are thus required to assess the effects of pharmacological Ang2 blockade for cancer patients particularly in the liver.

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Optical Imaging and Measurement of Angiogenesis

Sorg

2011

Advances in Optical Imaging for Clinical Medicine

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Inhibition of In Vivo Tumor Angiogenesis and Growth Via Systemic Delivery of an Angiopoietin 2-Specific RNA Aptamer

Cited by 49 publications

References 40 publications

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

G‐CSF rescues tumor growth and neo‐angiogenesis during liver metastasis under host angiopoietin‐2 deficiency

Optical Imaging and Measurement of Angiogenesis

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