Inhibition of immunological function mediated DNA damage of alveolar macrophages caused by cigarette smoke in mice

Ishida, Tadao; Hirono, Yuriko; Yoshikawa, Kunio; Hutei, Yoshimi; Miyagawa, Matsuo; Sakaguchi, Ikuyo; Pinkerton, Kent E.; Takeuchi, Masaru

doi:10.1080/08958370903176727

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“…Takeuchi et al have suggested the relationship between intracellular ROS and induced oxidative DNA damage in human neutrophil-like cells [13]. Our data is similar to a prior report that CS or CS extract induces DNA damage in human lung tissue and B-lymphoblastoid cell line MCL-5 [14], [15], human bronchial epithelial cells and lung fibroblasts without leading to apoptosis or necrosis [16], [17]. Accordingly, it is considered that CS-induced DNA damage of AM may lead to altered cellular functions and affect the pulmonary immune system.…”

Section: Effect Of Cs On Dna Damage In Amsupporting

confidence: 82%

Cigarette Smoke Induce Alteration of Structure and Function in Alveolar Macrophages

Hirono¹,

Ayaka²,

Nose³

et al. 2013

IJBBB

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Abstract-Cigarette smoke (CS) is released into the atmosphere, and impact lung health in non-smoker but not smoker. CS is inhaled into the lung by respiration and affects alveolar macrophages (AM). AM play an important role of immune system in the lung. In this study, we investigated the effect of CS on DNA damage and immune function in AM. The number of AM was significantly increased in CS exposed mice compared with non CS-exposed mice. Expressions of CD11b, TLR-2 and CD14 on AM were significantly inhibited in CS exposed mice but not CD16. Phagocytic activity of AM was significantly inhibited in CS exposed mice. Both of tail moment and tail length of AM as indicator of DNA damage were significantly increased in CS exposed mice. CS was a risk factor for DNA damage of AM and induced inhibition of immunological functions in AM mediated with DNA damage. These results suggest that changes of intracellular structure, inhibition of phagocytosis and TLR expression and induced-DNA damage of AM by CS may result in easily infection of bacteria or virus and carcinogenesis.

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