Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells

Weise, Christin; Hilt, Kerstin; Milovanović, M; Ernst, Dennis; Rühl, Ralph; Worm, Margitta

doi:10.1016/j.jnutbio.2010.02.004

Cited by 36 publications

(34 citation statements)

References 61 publications

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“…It is possible that increased B-cell activation could have potential clinical utility, especially in terms of antibody production. A few labs have studied the impact of FO on antibody production with mixed results (46)(47)(48)(49). Altogether, these data highlighted the notion that FO is not universally immunosuppressive.…”

Section: Disruption Of Rafts With Fo Was Accompanied By Differential mentioning

confidence: 99%

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

Rockett

Teague

Harris

et al. 2012

Journal of Lipid Research

110

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Section: Disruption Of Rafts With Fo Was Accompanied By Differential mentioning

confidence: 99%

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

Rockett

Teague

Harris

et al. 2012

Journal of Lipid Research

110

View full text Add to dashboard Cite

“…One study demonstrated DHA treatment of human B cells suppressed IgE when activated with IL-4/anti-CD40 ( 41 ). Similarly, another study showed consumption of longchain n-3 PUFAs by female mice lowered the antibody response for pups in response to ovalbumin ( 42 ).…”

Section: Implications Of Enhancing Transitional and Marginal Zone B Cmentioning

confidence: 99%

n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity

Teague

Fhaner

Harris

et al. 2013

Journal of Lipid Research

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“…A few studies in the past focused on antibody production, revealing highly mixed results (Jang et al, 2014; Lauritzen et al, 2011; Selvaraj and Cherian, 2004; Weise et al, 2011). Differences between these studies were vast, ranging from experiments using birds to rats with different doses and intervention times with n-3 PUFAs.…”

Section: N-3 Pufa Supplementation Enhances B Cell Activation and Amentioning

confidence: 99%

N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections

Whelan

Gowdy

Shaikh

2016

European Journal of Pharmacology

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B cell antigen presentation, cytokine production, and antibody production are targets of pharmacological intervention in inflammatory and infectious diseases. Here we review recent pre-clinical evidence demonstrating that pharmacologically relevant levels of n-3 polyunsaturated fatty acids (PUFA) derived from marine fish oils influence key aspects of B cell function through multiple mechanisms. N-3 PUFAs modestly diminish B cell mediated stimulation of classically defined naïve CD4+ Th1 cells through the major histocompatibility complex (MHC) class II pathway. This is consistent with existing data showing that n-3 PUFAs suppress the activation of Th1/Th17 cells through direct effects on helper T cells and indirect effects on antigen presenting cells. Mechanistically, n-3 PUFAs lower antigen presentation and T cell signaling by disrupting the formation of lipid microdomains within the immunological synapse. We then review data to show that n-3 PUFAs boost B cell activation and antibody production in the absence and presence of antigen stimulation. This has potential benefits for several clinical populations such as the aged and obese that have poor humoral immunity. The mode of action by which n-3 PUFA boost B cell activation and antibody production remains unclear, but may involve Th2 cytokines, enhanced production of specialized proresolving lipid mediators, and targeting of protein lateral organization in lipid microdomains. Finally, we highlight evidence to show that different n-3 PUFAs are not biologically equivalent, which has implications for the development of future interventions to target B cell activity.

show abstract

Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells

Cited by 36 publications

References 61 publications

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity

N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections

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