1993
DOI: 10.1159/000236406
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Inhibition of IgE-Mediated Leukotriene Generation and Bronchoconstriction in Primates with a New 5-Lipoxygenase Inhibitor, E6080

Abstract: The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzyl-amino)-4,5,7-trimethylbenzothiazole hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments at similar concentrations: the IC50s of E6080were 1.11 and 0.96 μM, respectively. AA861 also inhibited both leukotriene C4 generations with IC50s of 0.7… Show more

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Cited by 2 publications
(1 citation statement)
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“…Since many mite-allergic patients react to Der f 2 allergens, the 4 monkeys positive for both rDer f 2 and mite extract should be a good model of house dust mite allergy in humans. Although sensitivity and reactivity to the sensitizing antigen in our monkeys were comparable with that of pollen-sensitized animals in several studies [8,27], monkeys showing a larger histamine release from basophils (60-80%) and a lower provocative concentration for skin reaction ( 0.1 µg/ ml of antigen) in response to Ascaris suum or Japanese cedar allergens were reported [28,29]. Additional immunization of our monkeys may achieve a stronger sensitization to mite antigens.…”
Section: Discussionsupporting
confidence: 54%
“…Since many mite-allergic patients react to Der f 2 allergens, the 4 monkeys positive for both rDer f 2 and mite extract should be a good model of house dust mite allergy in humans. Although sensitivity and reactivity to the sensitizing antigen in our monkeys were comparable with that of pollen-sensitized animals in several studies [8,27], monkeys showing a larger histamine release from basophils (60-80%) and a lower provocative concentration for skin reaction ( 0.1 µg/ ml of antigen) in response to Ascaris suum or Japanese cedar allergens were reported [28,29]. Additional immunization of our monkeys may achieve a stronger sensitization to mite antigens.…”
Section: Discussionsupporting
confidence: 54%