Inhibition of IgE‐induced activation of human mast cells by IL‐10

Royer, Bernard; Varadaradjalou, Sonia; Saas, Philippe; Guillosson, Jean‐Jacques; Kantelip, Jean-Pierre; Arock, Michel

doi:10.1046/j.1365-2222.2001.01069.x

Cited by 154 publications

(122 citation statements)

References 57 publications

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“…This suggests that there are other cytokines involved in the regulation of the IgE response in this model. Some evidence suggests that IL-10 can down-regulate allergic hyperreactivity via direct effects on both DC (34,35) and mast cells (36). However, no study has yet demonstrated a mechanism by which helminth-induced immunoregulation directly affects the induction of allergic disease.…”

Section: Discussionmentioning

confidence: 99%

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen

Bashir

Andersen

Fuss

et al. 2002

The Journal of Immunology

214

161

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Although helminths induce a polarized Th2 response they have been shown, in clinical studies, to confer protection against allergies. To elucidate the basis for this paradox, we have examined the influence of an enteric helminth infection on a model of food allergy. Upon Ag challenge, mice fed peanut (PN) extract plus the mucosal adjuvant cholera toxin (CT) produced PN-specific IgE that correlated with systemic anaphylactic symptoms and elevated plasma histamine. PN-specific IgE was not induced in helminth-infected mice fed PN without CT. Moreover, when PN plus CT was fed to helminth-infected mice, both PN-specific IgE and anaphylactic symptoms were greatly diminished. The down-regulation of PN-specific IgE was associated with a marked reduction in the secretion of IL-13 by PN-specific T cells. When helminth-infected PN plus CT-sensitized mice were treated with neutralizing Abs to IL-10, the PN-specific IgE response and anaphylactic symptoms were similar to, or greater than, those seen in mice that receive PN and CT alone. Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE.

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Section: Discussionmentioning

confidence: 99%

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen

Bashir

Andersen

Fuss

et al. 2002

The Journal of Immunology

214

161

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“…It possesses the ability to inhibit both, the cellular proliferation and synthesis of cytokines by Th1 and Th2 cells (Del Prete et al 1993). IL-10 is able to inhibit the production of pro-inflammatory mediators such as IFN-γ, TNF-α and NO (Royer et al 2001). Studying the role of IL-10 in the immune response of S. mansoni chronically infected subjects, we demonstrated that in peripheral blood mononuclear cells (PBMC) cultures stimulated in vitro with S. mansoni antigens, neutralization of endogenous IL-10 with the monoclonal Ab anti-IL-10, restored IFN-γ production .…”

Section: The Role Of Parasite Infection On the Suscep-tibility Of Autmentioning

confidence: 90%

“…Recent studies have shown that during helminthiasis, Lacto N tetrose (LTNT), a sugar present in many kinds of helminths, and lacto N fucopentose (LNFP III), found in S. mansoni, act as inducing factors of both the type 2 response and production of IL-10 (Velupillai et al 2000). The ability of IL-10 to then inhibit the release of histamine and other mediators by cord blood mast cells (Royer et al 2001) could therefore be the mechanism behind the inhibition of the skin prick test reaction in schistosomiasis. A study evaluating children living in an endemic area of S. haematobium in Africa showed high levels of IL-10 and a decreased skin prick tests response suggesting that IL-10 may be involved in that process (van den Biggelaar et al 2000).…”

Section: Influence Of Parasite Infection On the Devel-opment Of Allermentioning

confidence: 99%

Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases

Araújo

Hoppe

Medeiros

et al. 2004

Mem. Inst. Oswaldo Cruz

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Section: Abstract: Schistosoma Mansoni Recombinant Proteins -S Mansmentioning

confidence: 99%

“…Studies have shown that IL-10 is protective against asthma, and increases in levels during immunotherapy (Akdis et al 1998). The protective role of IL-10 in asthma include the induction of IgG4 (Jeannin et al 1998), down-modulation of Th2 cytokine production (Araujo et al 2004) and the inhibition of histamine and other inflammatory mediators by mast cells (Royer et al 2001).Considering the potential of S. mansoni antigens in protecting against allergic diseases, this study aimed to evaluate some parasite antigens regarding their ability to induce IL-10 production. The S. mansoni antigens evaluated were Sm22.6, a soluble protein from the tegument, present in all life cycle of the worm with the exception of egg (Jeffs et al 1991).…”

mentioning

confidence: 99%

Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals

Cardoso

Oliveira

Pacífico

et al. 2006

Mem. Inst. Oswaldo Cruz

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Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin . The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral bloods mononuclear cells were stimulated with the S. mansoni recombinant antigens Sm22.6, Sm14, P24, was measured in the supernatants of cultures. As the recombinant antigens were cloned in Escherichia coli, we blocked contaminant endotoxin with polymyxin B added to the cultures. We demonstrated that all antigens used drove high production of IL-10 in S. mansoni infected individuals (n = 13, 408 ± 514 and 401 ± 383 pg/ml, 484 ± 245 pg/ml, 579 ± 468 pg/ml, respectively). In asthmatics infected with S. mansoni (n = 21) rP24 induced higher levels of rSm14 and rSm22.6 (184 ± 209 pg/ml; 292 ± 243 pg/ml; 156 ± 247 pg/ml, respectively). Conclusion: the S. mansoni antigens evaluated in this study stimulated IL-10 production by cells from infected individuals and therefore they have the potential to be used as a modulator of the inflammatory response in asthma. Key words: Schistosoma mansoni recombinant proteins -S. mansoni antigens -interleukin-10Evidences has accumulated that helminth infections protect against the development of allergy. For instance Lynch et al. (1993) demonstrated an inhibition of the skin prick test response to aeroallergens in individuals infected with Ascaris lumbricoides, and that the anti-helminthic treatment resulted in an increase in the prevalence of positive skin tests. These findings were supported by others authors (van den Biggelaar et al. 2000) and in the last few years some studies have demonstrated that Schistosoma mansoni infection not only suppresses the skin prick test response, but modulates asthma severity (Araujo et al. 2000, van den Biggelaar et al. 2000, Medeiros et al. 2003.Asthma is a multifatorial disease that results from genetic predisposition, exposure to allergens and environmental factors. While some environmental factors precipitate the development of asthma, others seem to be protective. This is the case of helminth infections, particularly S. mansoni, which through the modulation of the inflammatory response prevent asthma (Medeiros et al. 2003, Araujo et al. 2004. Studying the mechanisms behind the protection against allergy, Araujo et al. (2004) found that interleukin (IL-10) seems to play an important role in modulating the Th2 inflammatory response involved in the pathology of allergic diseases. Supporting this idea, Bigellar et al. showed high levels of this cytokine in individuals infected with S. haematobium who did not respond to skin test to aeroallergens (van den Biggelaar et al. 2000).It is well known that the acute phase of S. mansoni infection is characterized by a strong Th1 inflammatory response that evolues to a parasite antigen-driven Th2 response cronically . It is also known that this down modula...

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Inhibition of IgE‐induced activation of human mast cells by IL‐10

Cited by 154 publications

References 57 publications

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen

Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases

Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals

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