Keywords: 2-aminopyrimidine, 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides, bromination, antitubercular activity, X-ray structural analysis.Pyrimidine bases occur in a number of the most widespread heterocyclic systems in nature. Occurring in nucleic acids and coenzymes these compounds play a direct role in encoding and transmitting hereditary information, in the metabolism of carbohydrates and lecithin, and also in many biochemical processes important for animals and plants [2]. As a result, natural pyrimidines have an extremely broad spectrum of biological activities: from vitamins and regulators of biosynthesis amongst specific living organism proteins to antibiotics and alkaloids and to tetrodotoxin [3] which is one of the most powerful non-protein neurotoxins. Of course, pharmaceutical chemistry has not stood aside from the facts listed. As a result, to this day around 100 synthetic preparations [4] based on pyrimidine have been created and indeed used in medicinal practice. The majority of them fit into four broad categories of well known substances: barbiturates, sulfanilamides, antimicrobial pyrimidine-2,4-diamines, and antitumor agents [3]. Less impressive but none the less valuable for public health are such pharmacological groups as diuretics, antihypertensive and antihistamine agents, anticonvulsants, vitamins etc. [3,4].