Inhibition of<i>Helicobacter pylori</i>Adhesion to Human Gastric Mucus by a High-Molecular-Weight Constituent of Cranberry Juice

Burger, Ora; Weiss, Ervin I.; Sharon, Nathan; Tabak, Mina; Néeman, I.; Ofek, Itzhak

doi:10.1080/10408390209351916

Cited by 116 publications

(53 citation statements)

References 16 publications

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“…Nowadays, consumers are increasingly interested in their personal health and expect the foods to be sensory attractive and also safe and healthy. In the last years, in vitro and clinical studies have focused on certain microbial effects by cranberry phenolics [55]; condensed tannins of cranberry can inhibit the adhesion of uropathogenic fimbriated Escherichia coli to uroepithelial cells in the urinary tract [56,57]. Some extracts of cranberry have been also reported to inhibit the adherence of uropathogenic E. coli as well as the inhibition of the sialic-acid-specific adhesin of Helicobacter pylori to human gastric mucosa, a critical step in gastric ulcer development [58].…”

Section: Berry Phenolics and Biological Effects And Human Healthmentioning

confidence: 98%

Berries: Improving Human Health and Healthy Aging, and Promoting Quality Life—A Review

Paredes‐López

Cervantes-Ceja

Vigna-Pérez

et al. 2010

Plant Foods Hum Nutr

405

260

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The importance of the diet in relation to human health has increased the interest of consumers on nutraceuticals rich foods, and especially on fruits and vegetables. Berries are rich sources of a wide variety of antioxidant phenolics; these phytochemicals include flavonoids, stilbenes, tannins, and phenolic acids. Reactive oxidant species and free radicals are produced in an extensive range of physiological processes. In addition to the antioxidant defenses produced in the body, there are exogenous sources supplied by the diet; this is the case of berry fruits, among others. The insufficiency of antioxidant defense mechanisms is associated to the pathology of chronic disorders such as cardiovascular diseases, inflammation, and diabetes. Therefore, the enforcement of the latter mechanisms is of the utmost importance. The isolation and characterization of compounds that may delay the onset of aging is receiving intense research attention; some berry phenolics are being associated with this functional performance. Berry phenolics may also act as antimicrobials which may be of help in the control of the wild spectra of pathogens, in view of recent problems associated with antibiotic resistance. Most of the research works on the antioxidant activity of bioactive constituents of berries has been carried out using in vitro assays. In view of this, the human studies investigating the bioavailability and potential toxicity of phenolics are receiving more attention. Finally, we would like to emphasize the necessity of associating new plant breeding and genetic studies of berries with the expression and overexpression of compounds for human health and healthy aging.

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Section: Berry Phenolics and Biological Effects And Human Healthmentioning

confidence: 98%

Berries: Improving Human Health and Healthy Aging, and Promoting Quality Life—A Review

Paredes‐López

Cervantes-Ceja

Vigna-Pérez

et al. 2010

Plant Foods Hum Nutr

405

260

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“…It has been recently shown that high molecular weight compounds in cranberry and other berries, probably proanthocyanidins, may also interfere with the adhesion of H. pylori to human gastric mucus and to gastric epithelial cells. 59,60 Furthermore, various extracts of berries, alone or in combination, have been shown to inhibit the growth of H. pylori. 61 Recently Zhang et al…”

Section: Utilization Of Other Functional Dietary Components With Gastmentioning

confidence: 99%

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Gotteland

Brunser

Cruchet

2006

Aliment Pharmacol Ther

221

168

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SUMMARYHelicobacter pylori is a highly prevalent pathogen considered as an aetiological factor for gastroduodenal ulcers, and a risk factor for gastric adenocarcinoma and lymphoma in humans. Most subjects colonized by this micro-organism are asymptomatic and remain untreated. In symptomatic patients, the antibiotic treatment has a high cost and is not 100% effective because of resistance to antibiotics and to moderate patient compliance. This review discusses the role of probiotics as alternative solutions to assist in the control of H. pylori colonization in atrisk populations.The evidence that some strains of Lactobacillus and Bifidobacterium are able to inhibit H. pylori growth through the release of bacteriocins or organic acids, and may also decrease its adhesion to epithelial cells, is reviewed. In addition, probiotics have a possible role in the stabilization of the gastric barrier function and the decrease of mucosal inflammation. Other aspects that are considered are the contribution of probiotics to the healing of the gastric mucosa linked to their antioxidant and anti-inflammatory properties.Clinical trials in colonized adults and children are reviewed, and suggest that probiotics do not eradicate H. pylori but maintain lower levels of this pathogen in the stomach; in combination with antibiotics, probiotics may increase eradication rate and/or decrease adverse effects. Papers suggesting similar effects on H. pylori by foodstuffs such as berry juice and some milk proteins are quoted. Regular intake of these and other dietary products might constitute a low-cost, large-scale alternative solution applicable for populations at-risk for H. pylori colonization.

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“…The North American cranberry (Vaccinium macrocarpon) and its constituent products have been shown to provide numerous health benefits to humans, including antimicrobial, anti-virus, anti-mutagenesis, antiangiogenesis, and antioxidation (Pappas and Schaich 2009). The anti-microbial activity of cranberry has been widely recognized due to its potency in the prevention of urinary tract infections (Walker et al 1997) and probably stomach ulcers (Burger et al 2002), as well as improvement of oral hygiene (Steinberg et al 2004). The anti-microbial effect is likely attributable to the ability of cranberry to interfere with the adhesion of pathogens to the surfaces of host cells (Howell 2007;Sobota 1984).…”

Section: Introductionmentioning

confidence: 99%

The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

Guha

Cao

Kane

et al. 2012

AGE

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Nutraceuticals are known to have numerous health and disease preventing properties. Recent studies suggest that extracts containing cranberry may have anti-aging benefits. However, little is known about whether and how cranberry by itself promotes longevity and healthspan in any organism. Here we examined the effect of a cranberry only extract on lifespan and healthspan in Caenorhabditis elegans. Supplementation of the diet with cranberry extract (CBE) increased the lifespan in C. elegans in a concentration-dependent manner. Cranberry also increased tolerance of C. elegans to heat shock, but not to oxidative stress or ultraviolet irradiation. In addition, we tested the effect of cranberry on brood size and motility and found that cranberry did not influence these behaviors. Our mechanistic studies indicated that lifespan extension induced by CBE requires the insulin/IGF signaling pathway and DAF-16. We also found that cranberry promotes longevity through osmotic stress resistant-1 (OSR-1) and one of its downstream effectors, UNC-43, but not through SEK-1, a component of the p38 MAP kinase pathway. However, SIR-2.1 and JNK signaling pathways are not required for cranberry to promote longevity. Our findings suggest that cranberry supplementation confers increased longevity and stress resistance in C. elegans through pathways modulated by daf-16 and osr-1. This study reveals the anti-aging property of widely consumed cranberry and elucidates the underpinning mechanisms.

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Inhibition ofHelicobacter pyloriAdhesion to Human Gastric Mucus by a High-Molecular-Weight Constituent of Cranberry Juice

Cited by 116 publications

References 16 publications

Berries: Improving Human Health and Healthy Aging, and Promoting Quality Life—A Review

Berries: Improving Human Health and Healthy Aging, and Promoting Quality Life—A Review

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

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