“…Release of IL-6 in response to IL-1 has been demonstrated in other cell types such as fibroblasts (Sehgal, Walther & Tamm, 1987) and endothelial cells (Shalaby, Waage & Espevik, 1989) although IL-1 did not stimulate IL-6 release from anterior pituitary cells (Spangelo et al 1990¿>). IL-1 increases proliferation of thyrocytes (Mine, Tramontano, Chin & Ingbar, 1987;Kawabe, Eguchi, Shimomura et al 1989), but inhibits cAMP accumu¬ lation (Rasmussen, Bech, Feldt-Rasmussen et al 1988), iodide organification (Sato, Sato, Shizume et al 1990), thyroid peroxidase gene expression (Ashizawa, Yamashita, Tobinaga et al 1989), thyroglobulin production (Rasmussen et al 1988) and phagocytosis (Matsunaga, Eguchi, Fukuda et al 1988). IL-6 shows synergy with IL-1 in many of the actions of the latter in immune cells and, in some cases, IL-6 may be a mediator of the actions of IL-1 (van Snick, 1990).…”