“…Inhibitors. Several compounds are inhibitors of CYP2A6-mediated nicotine metabolism in vitro, including methoxsalen (8-methoxypsoralen), tranylcypromine, tryptamine, coumarin, and neomenthyl thiol (Nakajima et al, 1996b;Zhang et al, 2001;Le Gal et al, 2003;MacDougall et al, 2003). Other inhibitors of coumarin 7-hydroxylation such as pilocarpine, metyrapone, R-(ϩ)-menthofuran, -nicotyrine, naphthalene, 4,4Ј-dipyridyl disulfide, 2-(p-tolyl)-ethylamine, nootkatone, several azole antifungals, and rifampicin would also be expected to inhibit nicotine C-oxidation Tassaneeyakul et al, 2000;Fujita and Kamataki, 2001;Xia et al, 2002;Asikainen et al, 2003;Rahnasto et al, 2003;Denton et al, 2004).…”