Inhibition of Human Liver Cytochrome P450 by Star Fruit Juice

Jiangwei, Zhang; Liu, Yong; Cheng, Jie; Li, Wei; Ma, Hong; Liu, Hongtao; Sun, Jie; Wang, Liming; He, Yuqi; Wang, Yun; Wang, Zhengtao; Yang, Ling

doi:10.18433/j30593

Cited by 57 publications

(39 citation statements)

References 27 publications

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“…Correlation studies were performed by incubation of MPA (10 M, near K m value) with liver microsomes (0.3 mg/ml) from nine individual donors for 10 min. The isoform specific maker reactions were as follows (Zhang et al, 2007) …”

Section: Methodsmentioning

confidence: 99%

Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate

Liu¹,

Zhao²,

Wang³

et al. 2008

Drug Metab Dispos

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ABSTRACT:Medroxyprogesterone acetate (MPA) is one of the most frequently prescribed progestins for conception, hormone replacement therapy, and adjuvant endocrine therapy. MPA has a low oral bioavailability because of extensive metabolism; however, its metabolism was poorly documented. This study was intended to profile the phase I metabolites of MPA and the cytochrome P450 (P450) isoforms involved. After MPA was incubated with human liver microsomes and the NADPH-generating system, five main metabolites

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Section: Methodsmentioning

confidence: 99%

Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate

Liu¹,

Zhao²,

Wang³

et al. 2008

Drug Metab Dispos

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“…As for the incubations without inhibitor, 1% neat methanol was added. Final microsomal protein concentration and incubation time in different probe reactions were selected as described previously to ensure linear formation of metabolites during the incubations (Zhang et al, 2007). There was a 3 min preincubation at 37°C before the reaction was initiated by adding NADPHgenerating system.…”

Section: Assay With Hlmmentioning

confidence: 99%

“…The quantitative assay for the corresponding metabolites was performed as previous report (Zhang et al, 2007). The intra-and inter-day coefficients of variation were <7% at relevant concentrations (n = 6).…”

Section: Assay With Hlmmentioning

confidence: 99%

Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes

Liang

et al. 2013

Food and Chemical Toxicology

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“…The human liver microsomes (HLMs) isolated from 11 individuals using the procedure described above, and the relative activities of individual cytochrome P450 enzymes among the individual microsomal preparations had been determined previously using specific cytochrome P450 substrates (Zhang et al, 2007b;. Correlation studies were performed by incubation of liquiritigenin (25 μM) with HLMs (0.5 mg/ml) from 11 individual donors for 20 min.…”

Section: Correlation Studiesmentioning

confidence: 99%