Inhibition of Human Immunodeficiency Virus Type 1 by Lactic Acid Bacteria from Human Breastmilk

Martín, Virginia; Maldonado, Antonio; Fernández, Leónides; Rodríguez, Juan M.; Connor, Ruth I.

doi:10.1089/bfm.2010.0001

Cited by 53 publications

(42 citation statements)

References 26 publications

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“…Subsequently, TZM-bl cells were used to assess the effect of heat-killed bacteria and cell-free culture supernatants (CF-CS) on HIV-1 infectivity, as described previously (Martín et al 2010b). TZM-bl cells are derived from HeLa cells and engineered to stably express the HIV-1 receptor (CD4) and co-receptors (CCR5 and CXCR4) required for infection along with reporter genes for luciferase and β-galactosidase under the control of the HIV-1 promoter.…”

Section: Activity Against Hiv Infectivitymentioning

confidence: 99%

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

Langa

Maldonado‐Barragán

Delgado

et al. 2012

Appl Microbiol Biotechnol

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Lactobacillus salivarius CECT 5713, isolated from human milk, has immunomodulatory, anti-inflammatory and antiinfectious properties, as revealed by several in vitro and in vivo assays, which suggests a strong potential as a probiotic strain. In this work, the relationships between several genetic features of L. salivarius CECT 5713 and the corresponding phenotypes were evaluated. Although it contains a plasmid-encoded bacteriocin cluster, no bacteriocin biosynthesis was observed, possibly due to a 4-bp deletion at the beginning of the histidine kinase determinant abpK. The genome of L. salivarius CECT 5713 harbours two apparently complete prophages of 39.6 and 48 kbp. Upon induction, the 48-kbp prophage became liberated from the bacterial genome, but no DNA replication took place, which resulted in lysis of the cultures but not in phage progeny generation. The strain was sensitive to most antibiotics tested and no transmissible genes potentially involved in antibiotic resistance were detected. Finally, the genome of L. salivarius CECT 5713 contained four ORFs potentially involved in human molecular mimetism. Among them, protein 1230 was considered of particular relevance because of its similarity with dendritic cell-related proteins. Subsequently, in vitro assays revealed the ability of L. salivarius CECT 5713 to stimulate the maturation of immature dendritic cells and to inhibit the in vitro infectivity of HIV-1.

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Section: Activity Against Hiv Infectivitymentioning

confidence: 99%

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

Langa

Maldonado‐Barragán

Delgado

et al. 2012

Appl Microbiol Biotechnol

Self Cite

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“…Lactic acid, a final product of carbohydrate metabolism, is produced by all Lactobacillus species and is responsible for the homeostasis of the vaginal pH (B4.5). Acidic pH inactivates HIV (Martin et al, 2010) and HSV-2 (Tuyama et al, 2010). Moreover, HSV-2 is irreversibly inactivated by concentrations of lactic acid at the pH value corresponding to that observed in the healthy human vagina (Conti et al, 2009).It is appearing that lactobacilli could produce compounds that could help the host cells to defy viral replication (Mastromarino et al, 2011).…”

Section: Lab Antiviral Agents and Its Mechanism Of Actionmentioning

confidence: 99%

Overview of Anticancer activity of Lactic Acid bacteria

Delesa¹

2017

Int. J. Adv. Res. Biol. Sci.

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Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

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“…The risk of transmission by breast milk seems to be highest with mixed feeding and breastfeeding beyond 6 months of age [40]. Whilst these findings seem to suggest that breastfeeding by an HIV-infected mother is dangerous for the non-infected infant, there is growing evidence that breastfed infants have better chances of survival and may even be protected against HIV by lactic acid bacteria in breast milk [41]. …”

Section: Impact Of Infections On Nutritionmentioning

confidence: 99%

Interaction of Nutrition and Infections Globally: An Overview

Krawinkel¹

2012

Ann Nutr Metab

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The interaction of nutrition and infections is known by experience by generations of medical doctors. Before the era of antibiotics, diet was an integral part of the management of infections. Now, it is necessary to take a fresh look at this interaction as the understanding of immune response has expanded considerably. Comparatively little research has addressed the impact of nutrition interventions on the management of infectious diseases. Most observations of the interaction between nutrition and infections are epidemiological in character. This holds especially true for measles as well as for tuberculosis. In AIDS, the deterioration of the nutritional status is an indicator of disease progression. Infections in undernourished children are a common cause of death, and taking this finding into account helps to reduce the case fatality rate in severely malnourished patients. Regarding the immune response, cellular as well as soluble components are affected by deficiencies of single nutrients or general undernutrition. The immunosuppressive effect of undernutrition starts during intrauterine life already: maternal nutrition status has been shown to impact on immune function in adult animals. Recent research suggests that not only undernutrition but also caloric overnutrition impacts on immune response to infections and immunization. This is partly due to the chronic inflammatory activity of the adipose tissue and partly due to neuroendocrine alterations. Infectious diseases also impact on the nutritional status, either specifically or through unspecific mechanisms, such as anorexia, tachypnea, and vomiting.

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Inhibition of Human Immunodeficiency Virus Type 1 by Lactic Acid Bacteria from Human Breastmilk

Abstract: These results demonstrate for the first time that commensal LAB from human breastmilk inhibit HIV-1 infection in vitro and suggest a possible role for these bacteria in mucosal protection against HIV-1 in the breastfeeding infant.

Cited by 53 publications

References 26 publications

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

Overview of Anticancer activity of Lactic Acid bacteria

Interaction of Nutrition and Infections Globally: An Overview

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