Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin

Jenssen, Håvard; Sandvik, Kjersti; Andersen, Jeanette Hammer; Hancock, Robert E. W.; Gutteberg, Tore Jarl

doi:10.1016/j.antiviral.2008.03.004

Cited by 51 publications

(40 citation statements)

References 38 publications

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“…Similarly, both apo-and holo-lactoferrin has been demonstrated to interact both with canine herpes virus and surface receptors on the Madin-Darby canine kidney cells, thus inhibiting canine herpes virus infection [74]. With regard to the anti-herpes simplex virus 1 ability of lactoferrin, both bovine and human lactoferrin and lactoferricin have demonstrated the ability to block viral entry and also inhibit viral cell-to-cell spread in a dose dependent manner [55,[77][78][79], through interaction with negatively charged glycosaminoglycans like heparan sulphate on the cell surface [55,[80][81][82][83] and elements of the viral particle [55]. Differently from herpes simplex virus 1, Marchetti et.…”

Section: Protein Composition Of Milk and Their Antiviral Activitymentioning

confidence: 99%

“…Herpes simplex virus 1 human and bovine lactoferrin and lactoferricin, lactoperoxidase Binding to both virus particle and cellular receptors (heparan sulphate) to prevent viral adsorption and entry; Interference with intracellular replication events or synthesis of progeny viral components [9,35,55,[77][78][79][81][82][83] chemically modified milk proteins e.g. serum albumin, -lactalbumin, -lactoglobulin [89,93,99,100] Herpes simplex virus 2 human and bovine lactoferrin…”

Section: Virus Protein or Peptide Model Of Antiviral Function Referenmentioning

confidence: 99%

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Milk Derived Peptides with Immune Stimulating Antiviral Properties

Sun¹,

Jenssen²

2012

Milk Protein

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Section: Protein Composition Of Milk and Their Antiviral Activitymentioning

confidence: 99%

Section: Virus Protein or Peptide Model Of Antiviral Function Referenmentioning

confidence: 99%

Milk Derived Peptides with Immune Stimulating Antiviral Properties

Sun¹,

Jenssen²

2012

Milk Protein

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“…blocking the uncoating of viral genomes or the trafficking of virion components). Recently, bovine lactoferrin, in addition to inhibiting virus attachment and/or entry, has been shown to inhibit cell-to-cell virus spread, possibly by interacting with the structural viral proteins ICP5 (major capsid protein) and VP16 (viral tegument protein) (Jenssen et al, 2008). Lactoferrin and its cleavage product lactoferricin also interfere with trafficking of HSV-1 capsids along microtubules towards the nucleus (Marr et al, 2009).…”

Section: ±012mentioning

confidence: 99%

In vitro antiviral activity against herpes simplex virus in the abalone Haliotis laevigata

Vinh

Benkendorff

Speck

2010

Journal of General Virology

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As viruses are extremely abundant in oceans, marine organisms may have evolved novel metabolites to protect themselves from viral infection. This research examined a well-known commercial gastropod, abalone (Haliotidae), which in Australia have recently experienced disease due to a neurotropic infection, abalone viral ganglioneuritis, caused by an abalone herpesvirus (AbHV). Due to the lack of molluscan cell lines for culturing AbHV, the antiviral activity of the abalone Haliotis laevigata was assessed against another neurotropic herpesvirus, herpes simplex virus type 1 (HSV-1), using a plaque assay. The concentration range at which abalone extract was used for antiviral testing caused minimal (,10 %) mortality in Vero cells. Haemolymph (20 %, v/v) and lipophilic extract of the digestive gland (3000 mg ml "1 ) both substantially decreased the number and size of plaques. By adding haemolymph or lipophilic extract at different times during the plaque assay, it was shown that haemolymph inhibited viral infection at an early stage. In contrast, the antiviral effect of the lipophilic extract was greatest when added 1 h after infection, suggesting that it may act at an intracellular stage of infection. These results suggest that abalone have at least two antiviral compounds with different modes of action against viral infection, and provide a novel lead for marine antiviral drug discovery. INTRODUCTIONThe greatest biodiversity on earth is found in oceans, with 32 of the 33 animal phyla, 14 of which are not found on land (Nybakken & Bertness, 2005). Currently there are an estimated 230 000-275 000 taxonomically described marine species, and with the new species inventory accruing 1300-1500 species a year, there is predicted to be between 1.4-1.6 million species of macrofauna and flora in the ocean (Bouchet, 2006). Viruses are also abundant in oceans, with about 10 9 or more viruses per litre of water, exceeding numbers of bacteria and Archaea by about 15-fold (Bergh et al., 1989;Fuhrman, 1999;Suttle, 2007). Viral infections are common in marine environments, with an estimated 10 23 infections occurring every second (Suttle, 2007).Due to natural selection, a range of antiviral agents may have evolved in marine organisms to protect them from viruses. The innate defences available to marine organisms can include secondary metabolites, bioactive peptides and proteins, thus serving as models for the development of new drugs for treating human disease. Indeed, several important antiviral compounds of marine origin have been reported, including didemnins (Caribbean tunicate, Trididemnum solidum), eudistomins (shallow-water tunicates within the genus Eudistoma), mycalamide A and B (New Zealand sponge, Mycale sp.), papuamides A (Theonella mirabilis and Theonella swinhoei sponges), avarone (Dysidea avara sponge), gymnochrome D (fossil crinoid Gymnocrinus richer), microspinosamide (Sidonops microspinosa sponge), solenolide A (gorgonian of the genus Solenopodium), hennoxazole A (Polyfibrospongia sp. sponge), thyrsiferol (red alg...

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“…Herpes simplex virus can be inactivated by lactoferrin, lysozyme, HNP 1-4, and HBD 3, 5, and 6 and has developed immune evasion techniques to downregulate SLPI. [109][110][111] Similarly, human papilloma virus can be inactivated by HNP1-3 and 5 and downregulates SLPI and elafin as an immune evasion mechanism. 112,113 Neisseria gonorrhea is inactivated by LL37, which is also an anti-HIV factor.…”

Section: 93mentioning

confidence: 99%

Secreted Mucosal Antimicrobials in the Female Reproductive Tract that are Important to Consider forHIVPrevention

Ghosh

2014

American J Rep Immunol

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The mucosal microenvironment of the female reproductive tract (FRT) is rich in secreted endogenous antimicrobials that provide the first line of defense against pathogens. This review focuses on the spectrum of secreted antimicrobials found in the FRT that have anti-HIV functions and are regulated by the natural hormonal changes in women's life cycle. Understanding the complex nature of FRT, mucosal microenvironment will enable us to better design therapeutic interventions for women against sexually transmitted pathogens.

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Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin

Cited by 51 publications

References 38 publications

Milk Derived Peptides with Immune Stimulating Antiviral Properties

Milk Derived Peptides with Immune Stimulating Antiviral Properties

In vitro antiviral activity against herpes simplex virus in the abalone Haliotis laevigata

Secreted Mucosal Antimicrobials in the Female Reproductive Tract that are Important to Consider forHIVPrevention

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