Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding

Takken, Willem; Loon, Joop J. A. van; Adam, Wim

doi:10.1016/s0022-1910(00)00107-4

Cited by 127 publications

(109 citation statements)

References 24 publications

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“…Furthermore, electrophysiological recordings have been used to measure changes at the chemosensory level in A. aegypti, showing reductions in sensitivity to lactic acid in peripheral olfactory neurons after a blood meal (32). More recently, by using the malaria vector mosquito A. gambiae, host-seeking behaviors and electrophysiological responses to human odorants were also shown to decrease significantly in female mosquitoes shortly after ingestion of blood meals (33).…”

Section: Resultsmentioning

confidence: 99%

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

Fox

Pitts

Robertson

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

216

178

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Olfaction plays a major role in host preference and blood feeding, integral behaviors for disease transmission by the malaria vector mosquito Anopheles gambiae sensu stricto (henceforth A. gambiae). We have identified four genes encoding candidate odorant receptors from A. gambiae that are selectively expressed in olfactory organs, contain approximately seven transmembrane domains, and show significant similarity to several putative odorant receptors in Drosophila melanogaster. Furthermore, one of the putative A. gambiae odorant receptors exhibits female-specific antennal expression and is down-regulated 12 h after blood feeding, a period during which substantial reduction in olfactory responses to human odorants has been observed. Taken together, these data suggest these genes encode a family of odorant receptors in A. gambiae, whose further study may aid in the design of novel antimalarial programs.

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Section: Resultsmentioning

confidence: 99%

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

Fox

Pitts

Robertson

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

216

178

View full text Add to dashboard Cite

show abstract

“…1ng or higher) of the male from attraction to inhibition. Numerous examples have shown that behavioural responses to odours can be decreased as a function of physiological state (Baker and Cardé, 1979;Takken, 2001). However, these changes might be interpreted as a lack of motivation to respond rather than a case of (C)Seven neurons out of 13 analysed OG neurons in virgin males show a significantly higher spike frequency to the mixture of heptanal and pheromone than to heptanal alone (group 1, P0.02, N7).…”

Section: Discussionmentioning

confidence: 99%

Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect

Barrozo¹,

Gadenne²,

Anton³

2010

Journal of Experimental Biology

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SUMMARYIn the moth, Agrotis ipsilon, newly mated males cease to be attracted to the female-produced sex pheromone, preventing them from re-mating until the next night, by which time they would have refilled their reproductive glands for a potential new ejaculate. The behavioural plasticity is accompanied by a decrease in neuron sensitivity within the primary olfactory centre, the antennal lobe (AL). However, it was not clear whether the lack of the sexually guided behaviour results from the absence of sex pheromone detection in the ALs, or if they ignore it in spite of detection, or if the sex pheromone itself inhibits attraction behaviour after mating. To test these hypotheses, we performed behavioural tests and intracellular recordings of AL neurons to non-pheromonal odours (flower volatiles), different doses of sex pheromone and their mixtures in virgin and newly mated males. Our results show that, although the behavioural and AL neuron responses to flower volatiles alone were similar between virgin and mated males, the behavioural response of mated males to flower odours was inhibited by adding pheromone doses above the detection threshold of central neurons. Moreover, we show that the sex pheromone becomes inhibitory by differential central processing: below a specific threshold, it is not detected within the AL; above this threshold, it becomes inhibitory, preventing newly mated males from responding even to plant odours. Mated male moths have thus evolved a strategy based on transient odour-selective central processing, which allows them to avoid the risk-taking, energy-consuming search for females and delay re-mating until the next night for a potential new ejaculate.

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“…This type of plasticity occurs in another mosquito Anopheles gambiae in which odorant receptors for host cues are downregulated following a blood meal (Takken et al, 2001). It is likely that plasticity of pheromone response in C. fraxinella is regulated by allelic polymorphism of genes that control a more general reproductive diapause phenomenon in this species, and on-going research in our laboratory is examining variation in male accessory gland morphology and protein expression and spermiogenesis throughout the extended adult life stage.…”

Section: Discussionmentioning

confidence: 99%

Peripheral and behavioral plasticity of pheromone response and its hormonal control in a long-lived moth

Lemmen

Evenden

2009

Journal of Experimental Biology

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SUMMARYReproductive success in many animals depends on the efficient production of and response to sexual signals. In insects, plasticity in sexual communication is predicted in species that experience periods of reproductive inactivity when environmental conditions are unsuitable for reproduction. Here, we study a long-lived moth Caloptilia fraxinella (Ely) (Lepidoptera: Gracillariidae) that is reproductively inactive from eclosion in summer until the following spring. Male sex pheromone responsiveness is plastic and corresponds with female receptivity. Pheromone response plasticity has not been studied in a moth with an extended period of reproductive inactivity. In this study, we ask whether male antennal response and flight behavior are plastic during different stages of reproductive inactivity and whether these responses are regulated by juvenile hormone. Antennal response to the pheromone blend is significantly reduced in reproductively inactive males tested in the summer and autumn as compared with reproductively active males tested in the spring. Reproductively inactive autumn but not summer males show lower antennal responses to individual pheromone components compared with spring males. Treatment with methoprene enhances antennal response of autumn but not summer males to high doses of the pheromone blend. Behavioral response is induced by methoprene treatment in males treated in the autumn but not in the summer. Plasticity of pheromone response in C. fraxinella is regulated, at least in part, by the peripheral nervous system. Antennal and behavioral response to pheromone differed in reproductively active and inactive males and increased with methoprene treatment of inactive males.

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Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding

Cited by 127 publications

References 24 publications

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect

Peripheral and behavioral plasticity of pheromone response and its hormonal control in a long-lived moth

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