Inhibition of HIV infection by flavanoids

Mahmood, Naheed; Pìzza, Cosimo; Aquino, Rita Patrizia; Tommasi, Nunziatina De; Piacente, Sonia; Colman, Sue; Burke, Andrew; Hay, Alan J.

doi:10.1016/0166-3542(93)90095-z

Cited by 89 publications

(79 citation statements)

References 19 publications

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“…Scutellaria baicalensis, known as Chinese skullcap and Huang Qin, contains several flavonoids and is a widely used herb in traditional Chinese medicine with antitumor, antiviral, antibacterial and anti-inflammatory properties (7)(8)(9)(10)(11). Baicalein and wogonin are flavonoid-like chemical compounds which are found in Scutellaria baicalensis and have been reported to inhibit cell growth and induce apoptosis in various tumors (12,13).…”

Section: Introductionmentioning

confidence: 99%

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Kim

et al. 2012

Molecular Medicine Reports

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Abstract. The purpose of this study was to determine the effects of baicalein and wogonin, which are compounds derived from the Chinese herb Scutellaria baicalensis, in suppressing the viability of HT-29 human colon cancer cells. Following treatment with baicalein or wogonin, several apoptotic events were observed, including DNA fragmentation, chromatin condensation and increased cell cycle arrest in the G1 phase. Baicalein and wogonin decreased Bcl-2 expression, whereas the expression of Bax was increased in a dose-dependent manner compared with the control. Furthermore, the induction of apoptosis was accompanied by an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a dose-dependent manner. The administration of baicalein to mice resulted in the inhibition of the growth of HT-29 xenografts without any toxicity following 5 weeks of treatment. The results indicated that baicalein induced apoptosis via Akt activation in a p53-dependent manner in the HT-29 colon cancer cells and that it may serve as a chemopreventive or therapeutic agent for HT-29 colon cancer.

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Section: Introductionmentioning

confidence: 99%

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Kim

et al. 2012

Molecular Medicine Reports

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“…Cysteine and glutathione monoester inhibit chronic HIV expression (Mihm et al, 1991;Kalebic et al, 1991) whereas NAC and selenium are effective in inhibiting HIV activation in latently-infected cells (Roederer et al, 1990, Harakeh andJariwalla 1991;Sappey et al, 1994). It has been reported that alpha-lipoic acid can block acute infection (Bauer et al, 1991) and flavonoids including the polyphenol EGCG inhibit HIV at an early stage, blocking interaction of the virus with host-cells receptor (Mahmood et al, 1993, Fassina et al, 2002. More recently, green tea extract enriched in such polyphenols (80% by weight) was shown to suppress HIV production in chronically and latently infected cells (Jariwalla et al, 2010 Table 2.…”

Section: Role Of Micronutrients In Suppression Of Virus Infectionmentioning

confidence: 99%

Micronutrient Synergy in the Control of HIV Infection and AIDS

Jariwalla¹,

Niedzwiecki²,

Rath³

2011

Recent Translational Research in HIV/AIDS

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“…A number of flavans and flavones studied previously (Mahmood et al, 1993b) inhibited virus infection by irreversibly inactivating virus infectivity. The flavanones isolated from C. reflexa showed differences in their ability to neutralize virus, inhibit CD4/gp120 interaction and the virus enzymes reverse transcriptase and protease.…”

Section: Mode Of Actionmentioning

confidence: 99%

Constituents ofCuscuto Reflexaare anti-HIV Agents

Mahmood

Piacente

Burke

et al. 1997

Antivir Chem Chemother

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SummaryCrude water extracts of Cusano reflexa exhibited anti-HIV activity. Fractionation of the crude extract led to the isolation of nine pure compounds with closely related structures, showing interesting structure activity relationships. 3,5,7A'-Tetrahydroxyflavanone [oromadendrin) inhibited infection by binding to V3 loop of gp 120 and inhibiting its interaction with CD4, whereas 3,5,7,3'A'-pentahydroxyflavanone (taxifolin), with an extra OH group in the 3' position in ring Bwas less specific and exhibited less selectivity in cell cultures. In general, f1avanones containing an extra OH group in the 3' position (taxifolin, taxifolin-7-0-~-D-glucopyranoside and coccinoside B) were less specific and inhibited viral protease, reverse transcriptase, CD4/ gp 120 interaction in vitro and bound to non specific proteins. Other compounds isolated from c. reflexa were derivatives of quinic acids; 3A-O-dicaffeoylquinic acid was more active than 3-0-caffeoyl quinic acid. The anti-HIV activity of crude extract may be the result of combinatory effects with compounds of different modes of action.

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Inhibition of HIV infection by flavanoids

Cited by 89 publications

References 19 publications

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Micronutrient Synergy in the Control of HIV Infection and AIDS

Constituents ofCuscuto Reflexaare anti-HIV Agents

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