Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MlP-lα, MIP-1β, and SDF-1

Xiang, Jinhua; George, Sarah L.; Wünschmann, Sabina; Chang, Qing; Klinzman, Donna; Stapleton, Jack T.

doi:10.1016/s0140-6736(04)16453-2

Cited by 173 publications

(188 citation statements)

References 29 publications

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“…These include HLA-type (1)(2)(3)(4), HIV co-receptor expression (5), the cytidine deaminase APOBEC3G (6,7), tetherin (BST-2) (8), SAMHD1 (9,10), and an array of cytokines. Some cytokines such as type 1 and type 3 interferons, chemokines (e.g., stromal cell-derived factor 1, macrophage inflammatory factor 1a, RANTES (regulated on activation normal T cell expressed and secreted), and IL-27) inhibit HIV replication (11)(12)(13), whereas some enhance replication (IL-6 (14), tumor necrosis factor-␣ (15), IL-12 (16), and colony-stimulating factors (17,18)), and some are capable of either inhibiting or enhancing replication depending upon the culture system and conditions. In this regard, IL-2 has been shown to be capable of suppressing HIV-1 replication through the enhancement of CD8ϩ T cell function and enhancing HIV-1 replication in primary cultures of CD4ϩ T cells (19 -21).…”

Section: Il-2 Has Been Used In Culture Of Primary T Cells To Maintainmentioning

confidence: 99%

Interleukin-2 Inhibits HIV-1 Replication in Some Human T Cell Lymphotrophic Virus-1-infected Cell Lines via the Induction and Incorporation of APOBEC3G into the Virion

Oguariri¹,

Dai²,

Adelsberger

et al. 2013

Journal of Biological Chemistry

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Section: Il-2 Has Been Used In Culture Of Primary T Cells To Maintainmentioning

confidence: 99%

Interleukin-2 Inhibits HIV-1 Replication in Some Human T Cell Lymphotrophic Virus-1-infected Cell Lines via the Induction and Incorporation of APOBEC3G into the Virion

Oguariri¹,

Dai²,

Adelsberger

et al. 2013

Journal of Biological Chemistry

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“…As Xiang et al reported that the co-infection of GBV-C suppressed the HIV-1 replication through upregulation of RANTES, a natural CCR5 ligand, and also known as CCL5, in an in vitro study (25), we assessed the scenario by measuring the RANTES concentration in patients' plasma. In contrast to the in vitro study, however, much higher RANTES concentrations were observed in GBV-C-uninfected individuals.…”

Section: (A) (B)mentioning

confidence: 99%

Beneficial Effect of GB Virus C Co‐Infection in Human Immunodeficiency Virus Type 1‐Infected Individuals

Hattori

Okumura

Yamazaki

et al. 2007

Microbiology and Immunology

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Several reports have documented a better prognosis for HIV‐1‐infected patients co‐infected with GBV‐C, while other reports have contradicted such findings with the result that this issue remains controversial. We attempted to clarify the complicated status of the effect of GBV‐C co‐infection on HIV‐1‐infected patients. GBV‐C RNA was detected in 37 samples in 182 HIV‐1‐infected patients (20.3%) using RT/nested PCR. Of these, 3 were determined to be GBV‐C genotype 1, 12 were genotype 2, and the remaining 22 were genotype 3. The GBV‐C viral load quantified by real‐time PCR ranged from 7.8 × 103 to 3.3 × 106 copies/ml. Weakly negative correlation was observed between GBV‐C viral load and HIV‐1 viral load in 19 HAART‐naïve patients, indicating that a higher GBV‐C viral load is associated with a greater suppression of HIV‐1 replication. A previously published in vitro study suggested that GBV‐C infection would induce up‐regulation of RANTES, leading to suppression of HIV‐1 replication. However, in our present study, the blood RANTES level was significantly lower in the GBV‐C co‐infected group than in the uninfected group (190–9,959 vs. 264–31,038 pg/ml, P=0.004). Our results suggested that a suppression of HIV‐1 replication by GBV‐C co‐infection is not mediated by up‐regulated RANTES, and thus call for another as yet unknown factor.

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“…In experimental studies, GBV-C infection of peripheral-blood mononuclear cells resulted in decreased replication of both clinical and laboratory HIV strains that use either CCR5 or CXCR4 as their co-receptor. GBV-C induces HIV inhibitory chemokines and reduces the expression of HIV co-receptor CCR5 in vitro, that could block or reduce the decline of CD4 counts, hence justifying the better prognosis 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of GBV-C / HVG viremia in HIV-infected women

Silva

Rodrigues

Campos

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe present study aimed at standardizing a real-time quantitative polymerase chain reaction assay to evaluate the presence of GBV-C/HGV RNA. A "TaqMan" assay using primers and probe derived from the 5′ NCR region was developed and validated. Two hundred and fifty-three plasma samples from HIV-infected women were tested for GBV-C viremia and antibody against the envelope protein 2. GBV-C RNA was detected in 22.5% of the patients whereas the antibody was identified in 25.3% of the cohort. Detection of viral RNA and of antibodies was mutually exclusive. Viral loads showed a mean of 1,777 arbitrary units / mL, being 1.1 and 13,625 arbitrary units / mL respectively the lowest and highest values measured. We conclude that the real-time quantitative polymerase chain reaction method developed is appropriate for the investigation of GBV-C RNA since it was shown to be highly specific and sensitive, as well as requiring few steps, preventing contamination and providing additional information as to the relative viremia of carriers, a parameter that must be included in studies evaluating the co-factors influencing the clinical outcome of HIV/AIDS.

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Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MlP-lα, MIP-1β, and SDF-1

Cited by 173 publications

References 29 publications

Interleukin-2 Inhibits HIV-1 Replication in Some Human T Cell Lymphotrophic Virus-1-infected Cell Lines via the Induction and Incorporation of APOBEC3G into the Virion

Interleukin-2 Inhibits HIV-1 Replication in Some Human T Cell Lymphotrophic Virus-1-infected Cell Lines via the Induction and Incorporation of APOBEC3G into the Virion

Beneficial Effect of GB Virus C Co‐Infection in Human Immunodeficiency Virus Type 1‐Infected Individuals

Evaluation of GBV-C / HVG viremia in HIV-infected women

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