Inhibition of high glucose-induced inflammation and fibrosis by a novel curcumin derivative prevents renal and heart injury in diabetic mice

Chen, Hongjin; Yang, Xi; Lu, Kuang Lieh; Lu, Chun; Zhao, Yunjie; Zheng, Suqing; Li, Jieli; Huang, Zhangjian; Huang, Yi Wen; Zhang, Yali; Liang, Guang

doi:10.1016/j.toxlet.2017.07.212

Cited by 51 publications

(46 citation statements)

References 37 publications

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“…[27][28][29][30][31] However, many studies found that curcumin alleviates DCM. 2,32,33 In our study, both curcumin and curcumin/P reduced DCM through cross regulation effect of CaSR and endogenous CSE/H 2 S, while curcumin/P significantly decreased DCM.…”

Section: Effect Of Cars and Cari On Histopathologic Assessment Casrsupporting

confidence: 55%

“…[27][28][29][30][31] Recent studies have shown that curcumin alleviates DCM. 2,32,33 However, curcumin has very low water solubility and low bioavailability which limits its clinical application. 34 The process of curcumin on intestinal absorption induces biotransformation and curcumin is rarely absorbed into the bloodstream by an original drug.…”

Section: Introductionmentioning

confidence: 99%

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In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Tong

Chai

Jiang

et al. 2018

IJN

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BackgroundThe objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S).MethodsDiabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. The blood and myocardiums were collected, the level of serum H2S was observed, and the [Ca2+]i content was measured in myocardial cells, and hematoxylin-eosin, CaSR, CSE, and calmodulin (CaM) expression were detected.ResultsBoth curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.ConclusionPBLG-PEG-PBLG could improve water-solubility and bioactivity of curcumin and curcumin/PBLG-PEG-PBLG significantly alleviated diabetic cardiomyopathy.

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Section: Effect Of Cars and Cari On Histopathologic Assessment Casrsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Tong

Chai

Jiang

et al. 2018

IJN

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“…In fact, it is generally believed that enhanced extracellular matrix deposition and fibrosis are downstream of sustained inflammatory processes. A recent study by Chen and colleagues indicated that a curcumin derivative, J17, was able to significantly inhibit hyperglycemiainduced fibrosis in NRK-52E renal epithelial cells, H9C2 cardiomyoblast-like cells, and in the heart and kidneys of STZinduced diabetic mice (61). More specifically, transforming growth factor-beta (TGF-β) and collagen 1 (COL1) RNA and protein levels were both found to be greatly reduced in the heart and kidney tissues of J17-treated diabetic mice.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes

et al. 2019

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Chronic inflammation and oxidative stress lead to a multitude of adverse cellular responses in target organs of chronic diabetic complications. Curcumin, a highly investigated phytochemical, has been shown to exhibit both anti-inflammatory and antioxidant activities. However, the clinical application of curcumin has been greatly limited due to a poor pharmacokinetic profile. To overcome these limitations, we have generated analogs of curcumin to enhance bioavailability and offer a preferable pharmacokinetic profile. Here, we explored the effects of two mono-carbonyl curcumin analogs, L2H21 and L50H46, in alleviating indices of inflammation and oxidative stress in cell culture and mouse model of diabetic complications. Our results show that L2H21 and L50H46 normalize inflammatory mediators (IL-6 and TNF-α), extracellular matrix proteins (FN and COL4α1), vasoactive factors (VEGF and ET-1) and a key transcriptional coactivator (p300) in cultured human retinal microvascular endothelial cells (HRECs) and dermal-derived microvascular endothelial cells (HMVECs) challenged with high levels of glucose. These curcumin analogs also reduced glucose-induced oxidative DNA damage as evidenced by 8-OHdG labeling. We further show that treatment of streptozotocin-induced diabetic mice with curcumin analogs prevents cardiac and renal dysfunction. The preservation of target tissue function was associated with normalization of pro-inflammatory cytokines and matrix proteins. Collectively, our results show that L2H21 and L50H46 offer the anti-inflammatory and antioxidant activities as has been reported for curcumin, and may provide a clinically applicable therapeutic option for the treatment of diabetic complications.

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“…Curcumin has shown protective effects in several models of CVDs via decreasing hypertension (J. Hu et al, ), atherosclerosis (Zou, Zhang, Li, Zheng, & Feng, ), cardiac hypertrophy (Sunagawa et al, ), ischemia–reperfusion (I‐R) injury (H. Liu, Wang, Qiao, & Xu, ), and diabetic cardiovascular complications (H. Chen, Yang, et al, ; C. Li et al, ). Because elevated oxidative stress and the resulting proinflammatory responses both contribute to CVDs' development and progression, curcumin's inhibitory effect on ROS generation coupled with its anti‐inflammatory properties may contribute towards its protective effect against CVDs.…”

Section: Antioxidative and Anti‐inflammatory Properties Of Curcumin Imentioning

confidence: 99%

“…Another study has shown that curcumin analogue C66 inhibits high glucose‐induced rise in proinflammatory cytokines via regulation of the NF‐κB and c‐Jun N‐terminal kinase (JNK) signaling pathways (Pan et al, ). Additionally, J17, molecule with structural similarities to curcumin, has been demonstrated to suppress hyperglycemia‐induced inflammation, hypertrophy, and fibrosis, thereby, reducing key markers for renal and cardiac dysfunction in diabetic mice while also improving fibrotic and pathological changes in both renal and cardiac tissues (H. Chen, Yang, et al, ). Another group has studied the destruction of diabetic rat's cardiac microvasculature in 8‐ and 12‐week experiments.…”

Section: Antioxidative and Anti‐inflammatory Properties Of Curcumin Imentioning

confidence: 99%

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

Miao

et al. 2019

Phytotherapy Research

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It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have been used in traditional medicine for CVDs' management and other comorbidities for centuries. Numerous studies had delineated their anti‐inflammatory, antioxidative, and other medicinally relevant properties. Animal experiments and clinical trials have also demonstrated that turmeric and curcuminoids can effectively reduce atherosclerosis, cardiac hypertrophy, hypertension, ischemia/reperfusion injury, and diabetic cardiovascular complications. In this review, we introduce and summarize curcuminoids' molecular and biological significance, while focusing on their mechanistic anti‐inflammatory/antioxidative involvements in CVDs and preventive effects against CVDs, and, finally, discuss relevant clinical applications.

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Inhibition of high glucose-induced inflammation and fibrosis by a novel curcumin derivative prevents renal and heart injury in diabetic mice

Cited by 51 publications

References 37 publications

In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

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