Inhibition of HCN1 currents by norquetiapine, an active metabolite of the atypical anti-psychotic drug quetiapine
Nazzareno D'Avanzo,
Amélie Jean Jacques
Abstract:Background and Purpose Quetiapine is a second-generation atypical
antipsychotic drug that has been commonly prescribed for the treatment
of schizophrenia, major depressive disorder (depression), and other
psychological disorders. Targeted inhibition of
hyperpolarization-activated cyclic-nucleotide gated (HCN) channels,
which generate Ih, may provide effective resistance against
schizophrenia and depression. We investigated if HCN channels could
contribute to the therapeutic effect of quetiapine, and its major … Show more
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