Inhibition of Growth of Malignant Cells in vitro by a Component of Normal Adult Connective Tissue

Parshley, Mary S.; Mandl, Ines

doi:10.1038/208800a0

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…The method described in the present paper is of particular interest in that it permits the marking of MAA, thus allowing a biochemical quantification of the immature, connective stroma reaction in carcinomas. This fact could be of significance in cancerology, since the precise nature of the stromatumour relation is poorly understood, though it has been shown that a component of connective tissue, as well as connective tissue itself, could inhibit tumour growth (Parshley & Mandl, 1965;Haddow, 1967). The antigen's association with mesenchyme accounts for its presence in fibrosarcomas.…”

Section: Immunoftuorescencementioning

confidence: 99%

An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein

Delpech¹,

Delpech²,

Girard³

et al. 1979

Br J Cancer

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Anti-NSA3 antiserum was found to react with many kinds of benign and malignant tumours, as well as foetal skin and intestinal extracts. The corresponding antigens isolated from nervous tissue, benign breast adenoma, and a fibrosarcoma were compared. Immunoprecipitation cannot distinguish between these antigens, and their amino-acid contents were comparable. However, immuno-absorption identified an antigenic determinant that was confined to nervous tissue. Indirect immunofluorescence further confirmed the validity of the concept of a nervous form vs a mesenchymal form of the antigen. Furthermore, immunofluorescence enabled the localization of the antigen found in non-nervous tissue to mesenchyme (mesenchyme-associated antigen: MAA), whether the mesenchymal tissue be normal (foetal organs), tumoral (fibrosarcoma) or reactional (connective-tissue stroma of epithelial tumours). Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6

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Section: Immunoftuorescencementioning

confidence: 99%

An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein

Delpech¹,

Delpech²,

Girard³

et al. 1979

Br J Cancer

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“…In addition t o the prevention of overt ovarian cancers by removal of ovaries containing the epithelial inclusions interpreted as their precursors, several leads have appeared in the laboratory which could be applied t o the treatment of established ovarian cancer as follows: the use of extracts of skeletal muscle (12), the development of specific antibodies (13,14,15), and the production of specific lymphotoxins (16, 17, 18,19,20,21).…”

Section: Discussionmentioning

confidence: 99%

A survey of epithelial inclusions in the ovarian cortex of 470 patients

Mulligan

1976

Journal of Surgical Oncology

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The ovaries of 470 patients obtained for various indications at operation revealed 178 with 193 ovarian cysts and tumors - including 63 serous, 23 endometrial, and 27 mucinous - as well as 103 with tubal (serous), 35 with endometrial, and 2 with cervical (mucinous) epithelial inclusions. A very high frequency of transformation of mucinous epithelial inclusions into cysts and tumors contrasted with about 40% similar transformation of serous and endometrial inclusions into cysts and tumors.

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“…Investigations by Parshley and Mandl [8], Apple and Greenberg [2] and Bardos et al [3] had also demonstrated that cancer inhibitory factors were present in normal tissue extracts. Re search effort from this laboratory had 1 We wish to thank Doctors T. Namba, M. Ni chols and Mr. E. Tobin for advice and discussion, and Ms. E. Everinghim for excellent technical assistance.…”

Section: Szent-gyorgyimentioning

confidence: 99%

Inhibition of Growth of Mouse Ehrlich Ascites by Normal Tissue Extracts

Tong¹,

Bergevin²,

Appelbaum³

et al. 1978

Chemotherapy

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A dialyzable component from the aqueous extracts of mouse skeletal muscle and liver inhibited in vitro growth of a mouse Ehrlich ascites. A similar component was not detected in extracts of spleen, kidney, lung, skin, serum or small intestine. The muscle component appeared to be different from that of the liver in its resistance to heat and its stability in the culture medium. Both components however were stable on storage at 4, 23 and 37°C for 72 h. Intraperitoneal injection of the muscle and liver component into mice previously innoculated with Ehrlich ascites significantly decreased tumor incidence in these animals as compared with the control.

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Inhibition of Growth of Malignant Cells in vitro by a Component of Normal Adult Connective Tissue

Cited by 11 publications

References 9 publications

An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein

An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein

A survey of epithelial inclusions in the ovarian cortex of 470 patients

Inhibition of Growth of Mouse Ehrlich Ascites by Normal Tissue Extracts

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