Inhibition of gold thioglucose-induced hypothalamic obesity by glucose analogues

Likuski, HJ; Debons, AF; Cloutier, RJ

doi:10.1152/ajplegacy.1967.212.3.669

Cited by 111 publications

(16 citation statements)

References 2 publications

(2 reference statements)

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“…Another line of evidence is based on the hyperphagia seen after injury to the VMH caused by administration of goldthioglucose (GTG) [2,6,7,8,9,10,15,20,25,27]. It has been suggested that VMH glucoreceptors are unable to distinguish between GTG and glucose, take up GTG and then pay the penalty for their mistake [19].…”

Section: Discussionmentioning

confidence: 99%

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

Strubbe¹,

Mein²

1977

Physiology & Behavior

153

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Section: Discussionmentioning

confidence: 99%

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

Strubbe¹,

Mein²

1977

Physiology & Behavior

153

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“…Likuski, Debons & Cloutier (1967) have shown that the glucose moiety of GTG~s necessary for VMH necrosis in mice. However, it IS not clear to whHt extent amphibian metabolism is based on a glucose currency (Copeland & deRoos, 1971) and thus to what extent food intake control would be based on changes in glucose concentration.…”

Section: Discussionmentioning

confidence: 99%

Absence of lesions in the hypothalamus of frogs treated with gold thioglucose

Brown

Farrar

1980

Lab Anim

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“…Neither fasting nor the 2DG test alone is completely definitive, but if both tests are performed it is unlikely that a case of hypoglycemia would be missed. If the 2DG test is done first and is normal, there is no need to extend the fasting test for more than 24 h. If only the fasting test is performed, it should be extended for 36 h to pick up as many cases of hypoglycemia as possible. Determining blood glucose during spontaneously occumng symptoms remains a valuable means of detecting hypoglycemia.…”

Section: Plasma Glucose During the Fasting Testmentioning

confidence: 99%

“…The hyperglycemic response is the result of central inhibition of glucose transport in the hypothalamus (27). This results in acute sympathoadrenal (1,16,23,25,38), anterior pituitary (1, 25, 39), vagal (7, 13), and appetite responses (7,23,24,34,38) that are similar to those produced by insulin without the superimposed peripheral effects of insulin. The normal counter-regulatory response includes increases in plasma glucose, free fatty acids, lactate, epinephrine, cortisol, and suppression of insulin (1,23,25,38).…”

mentioning

confidence: 99%

The 2-Deoxyglucose Test as a Supplement to Fasting for Detection of Childhood Hypoglycemia

1984

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Summaryhvvodycemic, it is inevitably difficult and not without risk.The acute response to simulated hypoglycemia induced by 2-deoxyglucose (2DG) was compared with the prolonged fasting test as a possible screening test for detection of childhood hypoglycemia. Ten children, ages 2-9 yr, without a documented history of hypoglycemia were classified retrospectively as reference subjects. While fasting, their plasma glucose decreased to an average of 50 mg/dl (range, 30-74) between 28-36 h. After infusion of 2DG, 50 mg/kg IV over 30 min, their plasma glucose increased by an average of 35 mg/dl (range, 19-56) between 60-120 min. The half-life of plasma 2DG was 48 min.Twenty-three other children in the same age range had an abnormal response to one or both of these tests. Thirteen of these children became definitely hypoglycemic while fasting (glucose < 30 mg/dl) and also failed to increase their plasma glucose by more than 10 mg/dl after 2DG. Five children had plasma glucose values between 30-40 mg/dl during the first 24 h of fasting that were associated with a change in mental status but responded to 2DG with an increase in plasma glucose. The remaining five subjects had an apparently normal response to fasting but did not respond to 2DG; two of these had documented spontaneous hypoglycemia. No cases of documented hypoglycemia were undetected by either test. It is concluded that the 2DG test is a short safe supplement to fasting which is equally effective as the prolonged fasting test in detecting hypoglycemia. Neither test alone is completely reliable, but the combination is complementary. AbbreviationThe most direct approach to confirming a suspected diagnosis of spontaneous hypoglycemia is to measure blood glucose at the time of symptoms and, if possible, to demonstrate that symptoms are rapidly relieved after the blood glucose has been increased. This obvious approach is very often not successful in children because hypoglycemia is typically sporadic, brief, and may not be associated with definitive symptoms. When blood glucose values are obtained they may be equivocal. For these reasons, follow-up testing is frequently required to establish or confirm the diagnosis of hypoglycemia.Hypoglycemia in children due to various etiologies commonly occurs while fasting, and therefore fasting has been the most widely recommended general screening test (4, 10). If properly conducted, observations made during the fasting test can lead to a specific differential diagnosis in the event that the child does become hypoglycemic; however, as a test procedure, fasting has several practical disadvantages. Because the test may need to be continued for as long as 36 h or until the child becomes definitely ----~nter~retation may be compiicated by choice of appropriate reference standards and a variable relationship between blood glucose and symptoms (16). An especially frustrating outcome is to find that some children with documented spontaneous fasting hypoglycemia may fail to be distinguished from normal children under conditions ...

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Inhibition of gold thioglucose-induced hypothalamic obesity by glucose analogues

Cited by 111 publications

References 2 publications

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

Absence of lesions in the hypothalamus of frogs treated with gold thioglucose

The 2-Deoxyglucose Test as a Supplement to Fasting for Detection of Childhood Hypoglycemia

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