Inhibition of goby posterior intestinal NaCl absorption by natriuretic peptides and by cardiac extracts

Loretz, Christopher A.

doi:10.1007/bf02338291

Cited by 17 publications

(6 citation statements)

References 30 publications

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“…In the intestine, ANP potently inhibits NaCl absorption through the inhibition of Na-K-2Cl cotransporter in the winter flounder, Pseudopleuronectes americanus (65). Similar results are obtained in the goby, Gillichthys mirabilis (50). ANP stimulates chloride secretion (short-circuit current) in the isolated opercular epithelium of killifish (75).…”

Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelssupporting

confidence: 68%

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Takei, Yoshio, and Shigehisa Hirose. The natriuretic peptide system in eels: a key endocrine system for euryhalinity? Am J Physiol Regulatory Integrative Comp Physiol 282: R940-R951, 2002; 10.1152/ajpregu. 00389.2001.-The natriuretic peptide system of a euryhaline teleost, the Japanese eel (Anguilla japonica), consists of three types of hormones [atrial natriuretic peptide (ANP), ventricular natriuretic peptide (VNP), and Ctype natriuretic peptide (CNP)] and four types of receptors [natriuretic peptide receptors (NPR)-A, -B, -C, and -D]. Although ANP is recognized as a volume-regulating hormone that extrudes both Na ϩ and water in mammals, ANP more specifically extrudes Na ϩ in eels. Accumulating evidence shows that ANP is secreted in response to hypernatremia and acts to inhibit the uptake and to stimulate the excretion of Na ϩ but not water, thereby promoting seawater (SW) adaptation. In fact, ANP is secreted immediately after transfer of eels to SW and ameliorates sudden increases in plasma Na ϩ concentration through inhibition of drinking and intestinal absorption of NaCl. ANP also stimulates the secretion of cortisol, a long-acting hormone for SW adaptation, whereas ANP itself disappears quickly from the circulation. Thus ANP is a primary hormone responsible for the initial phase of SW adaptation. By contrast, CNP appears to be a hormone involved in freshwater (FW) adaptation. Recent data show that the gene expression of CNP and its specific receptor, NPR-B, is much enhanced in FW eels. In fact, CNP infusion increases 22 Na uptake from the environment in FW eels. These results show that ANP and CNP, despite high sequence identity, have opposite effects on salinity adaptation in eels. This difference apparently originates from the difference in their specific receptors, ANP for NPR-A and CNP for NPR-B. VNP may compensate the effects of ANP and CNP for adaptation to respective media, because it has high affinity to both receptors. On the basis of these data, the authors suggest that the natriuretic peptide system is a key endocrine system that allows this euryhaline fish to adapt to diverse osmotic environments, particularly in the initial phase of adaptation. atrial natriuretic peptide; ventricular natriuretic peptide; C-type natriuretic peptide; membrane guanylyl cyclase; water and electrolyte balance; molecular evolution; functional evolution; volume regulation; sodium regulation; Anguilla japonica ATRIAL NATRIURETIC PEPTIDE (ANP) was the first member of the natriuretic peptide (NP) family identified in mammals (17,63,69,86). Subsequent to the isolation and sequencing of ANP from the rat atria in 1983, brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were isolated from the porcine brain in 1988 and 1990, respectively, and they were identified as members of the NP family (Fig. 1). Whereas ANP and BNP are circulating hormones secreted from the heart, CNP is principally a paracrine factor in the brain and periphery (71). The basic structure of the NP peptides consists of an intramolecular...

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Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelssupporting

confidence: 68%

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Our current results provided the first direct evidence to show that ANP profoundly inhibits intestinal Na + absorption in vivo except in the dog where ANP inhibits it in the jejunum (Matsushita et al, 1991). There have been in vitro studies showing the inhibitory effect of ANP on short-circuit current in teleost intestine (O'Grady et al, 1985;Ando et al, 1992;Loretz, 1996). In the flounder, ANP inhibits Na et al, 1985), but in mammals, the ANP effect is mediated by Na + / glucose cotransporters (Gonzalez-Bosc et al, 2000).…”

Section: Discussionsupporting

confidence: 49%

Some Factors Affecting Drinking Behavior and Their Interactions in Seawater-Acclimated Eels, Anguilla japonica

et al. 2000

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-Atrial natriuretic peptide (ANP) decreases plasma Na + concentration and promtes seawater (SW) adaptation in eels. The hyponatremia may most probably be caused by increased branchial extrusion of Na + , but the mechanism has not been determined yet. The present study examined initially the effects of ANP on branchial Na + efflux in vivo using isotopic 22 Na. However, the efflux rate was not altered by infusion of a hyponatremic dose of ANP (5 pmol·kg). Therefore, we sought to examine whether the ANP-mediated hyponatremia is caused by a decrease in the uptake of Na + from the environment.Since a decrease in drinking was highly correlated with a degree of hyponatremia, conscious SW eels were infused with dilute SW into the stomach at a normal drinking rate to offset the antidipsogenic effect of ANP. Under this regimen, the hyponatremic effect of ANP was abolished. Then, we examined the site of Na + absorption in the alimentary tract by measuring the changes in ion composition of intraluminal fluid along the tract. Since Na + was absorbed at the esophagus and anterior/middle intestine, a sac was prepared at each site and the effects of ANP were examined in situ in conscious SW eels. ANP infusion did not alter Na + absorption at the esophagus, but it profoundly reduced the absorption at the intestine.Together with our previous finding that ANP does not alter renal Na + excretion, we propose that ANP reduces plasma Na + concentration in SW eels by inhibiting drinking and subsequent absorption of Na + by the intestine.

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“…Almost four decades later, the original observations by Smith were confirmed for rainbow trout acclimated to different salinities (Shehadeh and Gordon, 1969 (Shehadeh and Gordon, 1969). The study on rainbow trout reported direct measurements of pH in the intestinal or rectal fluids ranging between 8.1 and 9.0, depending on salinity ; 2 (Grosell et al, 2001); 3 (Grosell and Jensen, 1999); 4 (M.G., unpublished); 5 ; 6 (Marvao et al, 1994); 7 ; 8 (Musch et al, 1990); 9 (Mackay and Lahlou, 1980);10 (Smith et al, 1975); 11 (Gibson et al, 1987); 12 (Hickman, 1968); 13 (Loretz, 1996). and from which segment of the intestine the fluid samples were obtained.…”

Section: Anion Exchangementioning

confidence: 99%

Intestinal anion exchange in marine fish osmoregulation

Grosell

2006

Journal of Experimental Biology

227

211

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Osmoregulation in marine fishThree distinct strategies for maintaining salt and water balance have evolved in fishes inhabiting the marine environments. (1) Osmoconformity/ionoconformity is found in the strictly marine agnathan hagfishes, which do not appear to regulate osmotic pressure and concentrations of main osmolytes to a great extent in seawater (Morris, 1958). (2) Osmoconformity and ionoregulation are seen in marine elasmobranchs (Hazon et al., 2003) and in the lobe-finned coelacanth (Griffith et al., 1974), which maintains plasma osmolality at or slightly above that of the surrounding seawater but NaCl concentrations at approximately d of ambient levels. (3) The most common strategy is osmoregulation, found in all teleosts (Marshall and Grosell, 2005) and marine lampreys (Morris, 1958), achieved by the regulation of the main extracellular electrolyte (Na + and Cl -) levels at approximately d of full strength seawater. Under steady state conditions at constant salinities, hagfish, elasmobranchs and coelacanths presumably do not need to drink to maintain water balance. It was shown, however, that the unavoidable renal and extra-renal fluid loss to the hypertonic marine environment in hypo-osmoregulating fish was compensated for by ingestion of seawater with subsequent water absorption across the gastro-intestinal tract (Smith, 1930). More recently, it was demonstrated that even the osmoconforming elasmobranchs display transient drinking when exposed to elevated ambient salinity, and evidence for components of the rennin-angiotensin system (RAS), even in the elasmobranchs (Anderson et al., 2002;Hazon et al., 2003) and hagfish (Cobb et al., 2004) as well as in lamprey (Brown et al., 2005), continues to accumulate. The drinking reflex is at least in part controlled by RAS and it thus appears that the ability to regulate ingestion of seawater and thereby the magnitude of intestinal fluid absorption is an ancestral osmoregulatory trait among fishes.The ingestion and processing of the imbibed seawater for osmoregulatory purposes have, at least in teleost fish, received much attention for three quarters of a century since the first classic studies by Smith published in 1930(Smith, 1930. It is now well established that an initial desalinization of the ingested seawater occurs in the esophagus, which absorbs Na + and Cl -through both passive and active transport pathways, Despite early reports, dating back three quarters of a century, of high total CO 2 concentrations in the intestinal fluids of marine teleost fishes, only the past decade has provided some insight into the functional significance of this phenomenon. It is now being recognized that intestinal anion exchange is responsible for high luminal HCO 3 -and CO 3 2-concentrations while at the same time contributing substantially to intestinal Cl -and thereby water absorption, which is vital for marine fish osmoregulation. In species examined to date, the majority of HCO 3 -secreted by the apical anion exchange process is derived from hydration of metabolic ...

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Inhibition of goby posterior intestinal NaCl absorption by natriuretic peptides and by cardiac extracts

Cited by 17 publications

References 30 publications

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Some Factors Affecting Drinking Behavior and Their Interactions in Seawater-Acclimated Eels, Anguilla japonica

Intestinal anion exchange in marine fish osmoregulation

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