Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells

Chan, H. P.; Chan, Chi Ming; Ho, John W.

doi:10.1016/s0300-483x(03)00087-8

Cited by 71 publications

(49 citation statements)

References 18 publications

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“…The selenium-dependent glutathione peroxidase could detoxify both hydrogen peroxide and lipid hydroperoxides (Leopold, 1976;Sandstrom and Marklund, 1990). AFB 1 -induced reactive oxygen species formation and lipid peroxidation (LPO) might play a role in its cytotoxicity (Chan et al, 2003). AFB 1 -induced LPO was also found in hepatocytes (Liu et al, 1999).…”

Section: Discussionmentioning

confidence: 93%

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Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1

Geyikoğlu

Türkez

2005

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 93%

“…Recent studies have shown that aflatoxin B 1 enhances reactive oxygen species formation and causes oxidative damage (Chan et al, 2003). Also, AFB 1 plays a primary role in the generation of AFB 1 -mediated genetic damage (Wang and Groopman, 1999).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1

Geyikoğlu

Türkez

2005

Braz. arch. biol. technol.

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“…In fact, in vitro studies have shown that 5 μM of AFB 1 causes oxidative stress in a human hepatoma cell line (CHAN et al, 2003) and can react with components of cultured human blood cells, resulting in the formation of toxic intermediate compounds SISMAN, 2007). Furthermore, exposure of bovine peripheral blood mononuclear cells to AFB 1 (0, 5 and 20 μg/mL) increased intracellular reactive oxygen metabolites (BERNABUCCI et al, 2011).…”

Section: Effects Of Alatoxin Bmentioning

confidence: 99%

“…Oxidative damage is one of the potential mechanisms that makes AFB 1 able to induce cytotoxicity, carcinogenicity and mutagenicity in different cell and animal tissues (SHEN et al, 1995;CHAN et al, 2003;EL-GIBALY et al, 2003;LEE et al, 2005;ABBÈS et al, 2008;BERNABUCCI et al, 2011;AJIBOYE et al, 2013;MULDER et al, 2015). The oxidative process leads to the formation of the electrophilic AFB 1 -8,9-epoxide (SMELA et al, 2001;CHAN et al, 2003;HANIOKA et al, 2012), which reacts with guanine and other cellular macromolecules (i.e.…”

Section: Effects Of Alatoxin Bmentioning

confidence: 99%

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

Riella

Nones

2017

Biotemas

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ResumoMedidas para o controle da alatoxina B 1 : uma breve revisão sobre o uso de lavonoides e argilas. A alatoxina B 1 (AFB 1 ) é uma das micotoxinas mais abundantes e tóxicas produzidas por cepas toxigênicas.Esta substância afeta a viabilidade celular, sendo capaz de induzir a morte, tanto de células humanas, quanto de células animais. Medidas vêm sendo adotadas para minimizar os danos causados pela AFB 1 , incluindo a utilização de lavonoides (compostos polifenólicos extraídos de plantas) e bentonitas (um tipo de argila). Nesta revisão, as características físico-químicas da AFB 1 e seus efeitos em diferentes tipos de células, in vitro e in vivo, foram abordados. Além disso, a capacidade de proteção celular a partir de substâncias e materiais naturais, tais como lavonoides e bentonita, foi brevemente descrita. Também relatamos os efeitos econômicos causados pelas micotoxinas e sugerimos alternativas (lavonoides e bentonita) para novas abordagens terapêuticas visando combater a toxicidade causada por estas substâncias (AFB 1 ).Palavras-chave: Alatoxina B 1 ; Argila; Flavonoides; Mecanismo de ação AbstractAlatoxin B 1 (AFB 1 ) is one of the most abundant and toxic mycotoxins produced by toxigenic strains. This substance affects cell viability, inducing cell death in several human and animal cells. Measures have been taken to minimize damage caused by AFB 1 , including the use of lavonoids (polyphenolic compounds extracted from plants) and bentonites (a type of clay). In this review, the physicochemical characteristics of AFB 1 and its effects on different cells are discussed. Furthermore, the cellular protective effects of lavonoids and bentonites are briely reviewed. Finally, the emerging view of the economic effects caused by mycotoxins is briely discussed, along with how lavonoids and bentonites might open new pathways to develop approaches to ight the toxic effects caused by alatoxins.

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“…Glycyrrhizin, an oleanane-type triterpene saponin, is about 50 times sweeter than sugar which is being used as a sweetener and flavoring additive in the food industry (Chin et al, 2007). It has a wide range of pharmacological, anti-bacterial and anti-oxidant activities (Varsha et al, 2013), hepato-protective (Chan et al, 2003;Jeong et al, 2002;Kimura et al, 2001), antiulcer (He et al, 2001), antiallergy (Park et al, 2004). anticancer (Fiore et al, 2004;Salvi et al, 2003;Yoon et al, 2005), antiviral activity against various DNA and RNA viruses (Fiore et al, 2008), including HIV (De Clercq, 2000) and severe acute respiratory syndrome-associated coronavirus (Cinatl et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Isolation, cloning and bioinformatics analysis of β-amyrin 11-oxidase coding sequence from licorice

Shirazi¹,

Aalami

Tohidfar³

et al. 2016

Plant Omics

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Licorice is the roots and stolons of Glycyrrhiza uralensis which have several chemical compounds. Triterpene saponins such as glycyrrhizin and glycyrrhetinic acid and flavonoids like liquiritin, isoliquiritigenin and glabron are main compounds detected in liquorice root. The plant's major constituent is a glycyrrhizin. The β-amyrin 11-oxidase catalyzes the sequential two-step oxidation of β-amyrin in C-11 to produce 11-oxo-β-amyrin, a possible biosynthetic intermediate between β-amyrin and glycyrrhizin. In this study, the total RNA was extracted from licorice roots and cDNA synthesis, then PCR products were cloned into pTZ57R/T vector. Sequencing confirmed piece length of 1482 bp that encodes a protein of 493 amino acid residues. The results of alignment showe d 99% similarity to β-amyrin sequence of Glycyrrhiza uralensis. Subcellular studies using Softberry and Psort software showed that the activity of this protein is in endoplasmic reticulum. Moreover the protein has a signal peptide and is targeted to the secretory pathway. The results of phylogenetic tree determined most similar amino acid sequence to the CYP88D subfamily of cytochrome P450. These findings can be used for nucleotide or protein manipulation and transformation.

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Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells

Cited by 71 publications

References 18 publications

Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1

Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

Isolation, cloning and bioinformatics analysis of β-amyrin 11-oxidase coding sequence from licorice

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