Inhibition of Glycolysis for Glucose Estimation in Plasma: Recent Guidelines and their Implications

Gupta, Shalini; Kaur, Harpreet

doi:10.1007/s12291-013-0405-1

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…In our own hospital, the guidelines have not been communicated to frontline staff, eg phlebotomists, midwives, nurses, and doctors. The evidence highlighting the importance of sample handling has been known for decades, including knowledge that sodium fluoride is slow at inhibiting glycolysis 20 , but in contrast to the evidence from the HAPO study, we have found that this knowledge, despite being highlighted in more recent years 19,[21][22][23]29 has not been translated into everyday practice. …”

Section: Accepted Manuscriptcontrasting

confidence: 94%

See 1 more Smart Citation

The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese women

Daly

Stapleton

O’Kelly

et al. 2015

American Journal of Obstetrics and Gynecology

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Section: Accepted Manuscriptcontrasting

confidence: 94%

“…The importance of glycolysis in the accurate measurement of plasma glucose is well established 19 . The fall in glucose values is time-dependent and particularly important in samples where the phlebotomy-analysis interval exceeds 90 minutes 20,21,22 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese women

Daly

Stapleton

O’Kelly

et al. 2015

American Journal of Obstetrics and Gynecology

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“…Fluoride inhibits glycolysis enzymes, a capacity which is used in laboratories to assist blood glucose determination [155].…”

Section: Main Functionsmentioning

confidence: 99%

ESPEN micronutrient guideline

et al. 2022

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“…The higher mean glucose values observed with glucometer readings can be due to the fact that post prandial capillary blood has higher glucose concentration than venous plasma values [21]. Improper ratio of blood to anticoagulant, inadequate mixing of blood with the anticoagulant, delay in transportation of samples to the laboratory and delay in separation of plasma from whole blood may also cause substantial loss of glucose by glycolysis subsequently resulting in low blood glucose estimation by laboratory method [22]. In terms of clinical consequences of errors of each glucometer type is concerned, most values in no risk zone of Clarke and surveillance error grids was reported by Device 2 (83.3% and 93.3%) whereas almost all readings (99%) of other glucometer types also fell in acceptable zones, zone A and zone B.…”

Section: Discussionmentioning

confidence: 99%

Validity of over the counter finger stick glucose measurement devices in comparison with laboratory venous plasma glucose measurements on pregnant women with diabetes

et al. 2018

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Introduction Self-monitoring of fasting, pre and postprandial blood glucose (SMBG) is an integral part of diabetic care. The validity and accuracy of different glucometer types vary significantly and at present, none of the local authorities carry out pre or post marketing evaluation of these devices in Sri Lanka. This study evaluated the accuracy and validity of 3 types of SMBG devices available over the counter, Device 1, Device 2 and Device 3 against a standard laboratory reference method. Methods A random sample of 103 capillary and venous blood samples were analyzed from diabetic pregnant patients admitted to Teaching Hospital Peradeniya for Blood Sugar Series Testing. Haematocrit value was also obtained by microhaematocrit method. Analytical and clinical accuracy were determined. Results The correlation coefficiencies were 0.856, 0.880 and 0.873 for Device 1, Device 2 and Device 3, respectively. Only Device 2 met the International Standardization Organization (ISO) performance standards for glucometers for glucose values >100 mg/dL whereas none of them met the ISO criteria for values <100 mg/ dL. In surveillance error grids, 87.8%, 93.3% and 81.6% of the data points were within non risk zone for Device 1, Device 2 and Device 3 whereas 11.1%, 4.4% and 17.2% were within slightly lower risk hypoglycemia area. All types of glucometers were less reliable in detecting hypoglyacaemia. Conclusions The over the counter SMBG monitoring systems are encountering certain problems in terms of accuracy and validity. Clinicians should exercise caution in making clinical decisions based on glucometer values for diabetic pregnant patients.

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Inhibition of Glycolysis for Glucose Estimation in Plasma: Recent Guidelines and their Implications

Cited by 11 publications

References 11 publications

The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese women

The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese women

ESPEN micronutrient guideline

Validity of over the counter finger stick glucose measurement devices in comparison with laboratory venous plasma glucose measurements on pregnant women with diabetes

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