Inhibition of glycerol-3-phosphate acyltransferase by analogs of glycerol-3-phosphate

Perspectives of data analysis of enzyme inhibition and activation, part 4: Equations for calculation of constants of enzyme activation and inhibition

“…Several examples of the V i type of enzyme pseudoinhibition in practical enzymology are published in [14][15][16][17]; however, the authors usually refer such data to the associative VI i type of enzyme inhibition and use Eq. (4) of Table 2 for calculation of K IVi constants of inhibition of enzymes, i.e.…”

Perspectives of data analysis of enzyme inhibition and activation, Part 2: Parametrical classification of types of enzymatic reactions

“…However, this type does not belong to activated reactions, because it is an inhibited reaction by a ratio of initial reaction rates recorded experimentally (v i < v 0 ). The traditional reference of this type to competitive enzyme inhibition [8,9] does not only take into account the above-mentioned peculiarity of the mechanisms of proceeding of such reactions but leads to confusion because there is no similarity with the IV i type of enzyme inhibition in this case (Figures 4 and 5 in Table 1).…”