Inhibition of gentamicin–induced renal tubular cell necrosis

Tavafi, Majid

doi:10.5812/nephropathol.7512

Cited by 31 publications

(20 citation statements)

References 9 publications

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“…However, gentamicin‐induced nephrotoxicity put a serious limitation on its use. In some cases, the drug must be discontinued because of the severity of this side effect …”

Section: Introductionmentioning

confidence: 99%

“…RAS is essentially responsible for the pathogenic progression of kidney injury, because angiotensin II is likely to be a powerful inducer of reactive oxygen species (ROS) and alterations of oxidant‐antioxidant status in renal and cardiovascular diseases . It is postulated that gentamicin‐induced nephrotoxicity is greatly related to the generation of ROS in the kidney . These ROS provoke cellular damage and necrosis by means of lipid peroxidation and protein alteration .…”

Section: Introductionmentioning

confidence: 99%

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Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Ahmed

Mohamed

2018

J Biochem & Molecular Tox

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This study pointed to estimate the possible protective impacts of candesartan and/or epigallocatechin‐3‐gallate (EGCG) against gentamicin‐induced nephrotoxicity. The current work revealed that gentamicin significantly elevated relative kidney weight and the serum level of creatinine and urea. Also, renal level of malondialdehyde was significantly increased with a concurrent decrease in renal glutathione‐S‐transferase and superoxide dismutase activities. Moreover, renal levels of nuclear factor‐kappa B (NF‐κB) and p38 mitogen‐activated protein kinase (p38‐MAPK) were increased together with the elevation of tumor necrosis factor‐alpha and interleukin‐1 beta levels after gentamicin treatment. In addition, caspase‐3 expression was elevated, and histological examination revealed extreme alterations enlightening inflammation, degeneration, and necrosis. Pretreatments with candesartan and/or EGCG attenuated gentamicin‐induced nephrotoxicity. Importantly, the altered expression of p38‐MAPK and NF‐κB may play a significant role in the protective mechanisms exerted by candesartan and EGCG. Coadministration of candesartan and EGCG exhibited more profound response compared with the monotherapy.

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“…However, gentamicin‐induced nephrotoxicity put a serious limitation on its use. In some cases, the drug must be discontinued because of the severity of this side effect …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Ahmed

Mohamed

2018

J Biochem & Molecular Tox

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“…The etiologies of renal failure were diabetic nephropathy, hypertension, various glomerular diseases, autosomal dominant poly cystic kidney disease(ADPKD) and also urinary tract infections [32][33][34][35][36][37][38].According to the severity of secondary hyperparathyroidism, each patient was treated with oral active vitamin D3 (Rocaltrol), calcium carbonate, and Rena-Gel capsules at various doses. According to the severity of anemia, patients were treated with IV iron therapy Iron Source (venofer) at various doses after each dialysis session .All patients were under treatments of 6 mg folic acid daily, oral vitamin B-complex tablet daily and also 2000 U IV Eprex (recombinant human erythropoietin (rHuEPO) were given to each patient after each dialysis session routinely [39][40][41]. Exclusion criteria were active or chronic infection.…”

Section: Methodsmentioning

confidence: 99%

Age and Dialysis Adequacy in Maintenance Hemodialysis Patients

Nasri¹

2013

Ann Clin Anal Med

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ÖzetAmaç: Dializin optimal dozu ve sıklığı sorunu, dializ tedavisi alımında en önemli sorun başlığı olmuştur. Biz yaşın, bazı hemodiyaliz parametrelerin, özellikle üre reduksiyon hızı ile (URR) hemodializ yeterliliği üzerindeki etkisini değerlendirmeyi ve bu parametreleri diabetli ve diabetli olmayan hastalar arasında karşılaştırmaya çalıştık. Gereç ve Yöntem: İdame hemodiyaliz tedavisi alan End-stage (SON EVRE) hastalar dikkate alındı. Üre redüksiyon hızı ve boy kilo endeksleri hesaplandı. Bulgular: Tümü 60 kişi olan hastalar (K=21, E=39) 44 non-diyabetik hemodiyaliz(F=15, M=29) ve 16 (F=6, M=10) diyabetik hemodiyaliz hastasından oluşmakta idi. Non-diyabetikler ve diyabetikler arasında diyaliz yeterliliği açısından, diyabetik grupta düşük değerlerle, dikkate değer bir fark gözlendi ve 50 yaşındakilerle ve 50 yaş üstü hastalarda daha düşük değerlerle, kreatinin ve diyaliz yeterliliği açısından önemli bir fark gözlendi. Tüm hemodiyaliz hastalarında yaş ve hemodiyaliz yeterliliği arasın-da önemli bir negatif korelasyon gözlendi, ve aynı zamanda yaş ile serum kreatinin arasından dikkate değer bir negatif korelasyon belirlendi. Tartışma: Yaşın hemodiyaliz üzerine negatif etkisi daha fazla dikkate alınmalıdır, bu bakış açısıyla yaşlı hastalarda sıklıkla gözlenen diyaliz komplikasyonları azaltılabilir. Anahtar KelimelerHemodializ; Yaş; Üre Azalma Oranı; Diabetus Mellitus Abstract Aim: The issue of optimal dialysis dose and frequency has been a central topic in the delivery of dialysis treatment. We aimed to consider the effects of age on some hemodialysis parameters specially dialysis adequacy by urea reduction rate (URR) and to compare these parameters between diabetics and non diabetic HD(hemodialysis) patients. Material and Method: Patients with end-stage renal disease (ESRD), undergoing maintenance hemodialysis treatment were considered. The urea reduction rate and body mass index were calculated. Results: The total patients were 60 (F=21 M=39), consisting of 44 non diabetic hemodialysis patients (F=15 M=29), and 16 diabetic hemodialysis patients (F=6 M=10). A significant difference of dialysis adequacy between non-diabetics and diabetics was observed with lower values in diabetic group and a significant difference of dialysis adequacy and creatinine was observed in patients, with ages below and more than 50 years old with lower values in older patients. A significant negative correlation of age with dialysis adequacy in total hemodialysis patients and a significant negative correlation of age with serum creatinine were observed. Discussion:The negative effect of age on dialysis adequacy needs more attention to this aspect to reduce the dialysis complications which is frequently observed in older patients.

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“…8 More recently, we also observed that estrogen abolishes the protective effect of erythropoietin against CIN in ovariectomized rats, 9 whereas nephroprotective effects of erythropoietin were also detected in our previous study. [10][11][12] Hence, it is well documented that there is a gender difference in CIN in the rat model. It is documented that some cases of chronic kidney diseases are gender related too.…”

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confidence: 99%

The Authors Reply

Lázaro

Humanes

Jado

et al. 2013

Kidney International

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We appreciate the interest of Drs Nematbakhsh and Nasri 1 in our paper. 2 Some animal models suggest that sex hormones have an important role in the development of drug-induced nephrotoxicity. As for cisplatininduced nephrotoxicity (CIN), the novel data provided by the above-mentioned authors in rats show that CIN is sex related and therefore directly affects toxicity and the potential administration of renoprotectors. Although they found no renal dysfunction in female rats with CIN when compared with male rats, several nephroprotectors were shown to prevent CIN in male rats but http://www.kidney-international.org

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Inhibition of gentamicin–induced renal tubular cell necrosis

Cited by 31 publications

References 9 publications

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Age and Dialysis Adequacy in Maintenance Hemodialysis Patients

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