Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1

Way, LW; Durbin, Richard P.

doi:10.1038/221874a0

Cited by 107 publications

(41 citation statements)

References 10 publications

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“…In early in vitro studies on the amphibian gastric mucosa, PGE2 inhibited the secretory response to histamine but not to directly applied cyclic AMP (Way & Durbin, 1969). In studies in the rat in vivo, PGE2 inhibited the secretory responses to histamine yet failed to reduce the small secretory response to db cyclic AMP alone (Main & Whittle, 1974).…”

Section: Discussionmentioning

confidence: 99%

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

Boughton‐Smith

Whittle

1981

British J Pharmacology

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1 The characteristics of the antisecretory actions of prostaglandin E2 (PGE2) and two stable prostacycin analogues during different rates of acid stimulation have been evaluated in the lumen-perfused isolated whole stomach of the rat and mouse. 2 In the rat isolated stomach, histamine induced a dose-dependent increase in acid output. Preincubation with PGE2 caused a dose-related and surmountable inhibition. 3 The stable prostacycin analogues, 6/3-PGI1 and a 16-phenoxy derivative likewise caused a surmountable inhibition of histamine-stimulated acid output from rat stomach. 4 PGE2 had inconsistent actions on the acid secretion stimulated by pentagastrin, methacholine or dibutyryl cyclic adenosine 3',5'-monophosphate. 5 In the mouse isolated stomach, acid secretion was stimulated by low concentrations of histamine, pentagastrin or methacholine. 6 PGE2 failed to inhibit histamine-stimulated acid output from mouse stomach, but high concentrations of the potent 16-phenoxy analogue did show anti-secretory activity. 7 The results indicate the usefulness of the rat isolated stomach for studying the interaction of prostaglandins with the acid secretory process in mammalian gastric mucosa.

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Section: Discussionmentioning

confidence: 99%

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

Boughton‐Smith

Whittle

1981

British J Pharmacology

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“…PGE1 also inhibits the action of vasopressin on isolated collecting tubules of rabbit kidney cortex, but in this tissue, unlike its action in the bladder, PGE1 alone slightly increases net water transport (Grantham & Orloff, 1968). Similarly in isolated frog gastric mucosa PGE, inhibits gastrin-stimulated H+ secretion (Way & Durbin, 1969;Shaw & Ramwell, 1969) while alone it is capable of eliciting secretion (Shaw & Ramwell, 1969). A similar dual effect of prostaglandins El, E2, Fl.…”

Section: Discussionmentioning

confidence: 99%

“…A number of authors have observed that gastric acid secretion, stimulated by food, 2-deoxyglucose, histamine or gastrin, is inhibited by prostaglandin E1 (PGE1), both in vivo (Robert, Nezamis & Phillips, 1967, 1968Lippman, 1968;Shaw & Ramwell, 1968;Jacobson, 1970 and Nezamis, Robert & Stowe, 1971) and in vitro (Way & Durbin, 1969) and it is tempting to postulate that such inhibition is the result of the feed-back mechanism envisaged above.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin action on pancreatic blood flow and on electrolyte and enzyme secretion by exocrine pancreas in vivo and in vitro

Case¹,

Scratcherd²

1972

The Journal of Physiology

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SUMMARY1. Intra-arterial injection or infusion of prostaglandins E1 and E2 into anaesthetized cats caused a fall in arterial blood pressure, a reduction in pancreatic blood flow and an inhibition of secretin-stimulated pancreatic electrolyte secretion. In some experiments these effects were preceded by a transient increase in blood flow and secretion.2. The fall in blood pressure and reduction in blood flow, but not the inhibition of secretion, were much less marked following administration of the a-adrenergic blocking agent phenoxybenzamine. This stimulatory action was markedly potentiated by theophylline. 5. Enzyme secretion was not stimulated by any of the prostaglandins, even in the presence of theophylline.6. It is concluded that prostaglandins can stimulate electrolyte transport by exocrine pancreas, perhaps through a mechanism involving adenylate cyclase, but that in vivo this action is masked by a secondary inhibition resulting either from vasoconstriction, or from the vibration of an antisecretory agent, or both.

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“…Although prostaglandin E1 can also inhibit secretion in the isolated bullfrog mucosa (Way & Durbin, 1969) its mechanism of action in vivo…”

Section: Introductionmentioning

confidence: 99%

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

Main

Whittle

1973

British J Pharmacology

153

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Summary The effects of prostaglandins E1, E2, A1 and A2 on gastric acid secretion and mucosal blood flow were studied by means of a [14C]‐aniline clearance technique in the anaesthetized rat. During intravenous administration of these prostaglandins, in doses which almost completely inhibited pentagastrin‐ and histamine‐induced acid secretion, a fall in clearance was observed. Clearance per unit acid secretion increased during prostaglandin administration, precluding a primary reduction in mucosal blood flow as the mechanism of the antisecretory action. Prostaglandins increased clearance during basal secretion, indicating a direct vasodilator effect on the gastric mucosa. The possibility that endogenous prostaglandins contribute to functional vasodilatation in the gastric mucosa and that exogenous prostaglandins may be of clinical value in the treatment of peptic ulcer is discussed.

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Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1

Cited by 107 publications

References 10 publications

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

Prostaglandin action on pancreatic blood flow and on electrolyte and enzyme secretion by exocrine pancreas in vivo and in vitro

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

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Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1

Cited by 107 publications

References 10 publications

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

Prostaglandin action on pancreatic blood flow and on electrolyte and enzyme secretion by exocrine pancreas in vivo and in vitro

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

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THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E₂ AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro