Inhibition of gastric acid secretion by somatostatin and analogs in the rat

Lippmann, W.; Borella, Luis E.

doi:10.1016/0031-6989(76)90053-9

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…In the awake animal the effect of somatostatin on pentagastrin-stimulated gastric acid secretion has been studied in the rat [20], the cat [4][5][21][22], the dog [6,[23][24] and in man [3]. A single study in man examined the effect of somatostatin on gastric secretion stimulated by exogenous gastrin [2].…”

Section: Discussionmentioning

confidence: 99%

Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion

et al. 1979

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The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine. Evidence is produced that somatostatin competitively inhibits gastrin-stimulated acid secretion whereas it inhibits carbamylcholine-stimulated acid secretion by a mechanism which is non-competitive in nature and it has no action on histamine-stimulated secretion. The model of the persued stomach in the anaesthetized rat seems suitable to study the inhibition caused by drug on stimulated acid secretion.

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Section: Discussionmentioning

confidence: 99%

Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion

et al. 1979

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“…Included among these are special diets, and the neutralization or suppression of gastric acid secretion by antacid or anticholinergic compounds. More recently the goal of suppress ing gastric acid secretion has focused on the use or potential use of histamine H2 blockers (3,4,11 ), prostaglandin and somatostatin analogs (17,10). However, the anticholinergics still enjoy widespread therapeutic use.…”

mentioning

confidence: 99%

A Study in Mice of Benzodiazepine-Anticholinergic Interaction: Protection against Restraint-Immersion and Forced Exertion-Induced Gastric Mucosal Erosion

Dairman¹,

Juhász²

1978

Pharmacology

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The effectiveness of benzodiazepines arid anticholinergics administered alone or in combination in preventing restraint-immersion and forced exertion-induced gastric mucosal erosion was investigated in mice. The benzodiazepines used were diazepam and chlordiazepoxide HCI and the anticholinergics were propantheline bromide and clidinium bromide. The administration of a benzodiazepine with an anticholinergic resulted in additive or supra-additive protective effects in both systems. In the restraint-immersion system, diazepam combined with propantheline bromide at a ratio of 1 to 13.7 yielded a 4.53-fold supra-additive effect. At ratios of 4.6 or 1.5 parts of propantheline bromide to 1 part of diazepam an additive effect was observed. One part of diazepam, when combined with 1.4 to 12.0 parts of clidinium bromide resulted in supra-additive effects of about 1.5-fold. The co-administration of chlordiazepoxide HCI and clidinium bromide in ratios of 2 to 1 or 2.5 to 1 resulted in supra-additive effects of 2.4- and 1.85-fold, respectively. At higher and lower ratios additive effects were demonstrated. In the forced exertion system, diazepam combined with either anticholinergic resulted in supra-additive effects of 2- to 3-fold which occurred at ratios of diazepam to the anticholinergic varying over an 8-fold range. The co-administration of 2 parts of chlordiazepoxide HCI and 1 part of clidinium bromide resulted in a 2.84-fold supra-additive effect in the forced exertion system. These results are discussed in relation to the use of benzodiazepine anticholinergic combinations in the treatment of human gastric and duodenal ulcer disease.

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“…In order to demonstrate the effectiveness of somatostatin in the rat, we have confirmed its effect on pentagastrin-stimulated gastric acid output as described previously (Lippman & Borella, 1976 Raptis et al (1978) also observed no effect of somatostatin on bile volume in man.…”

Section: Discussionmentioning

confidence: 61%

“…It inhibits growth hormone (Ferland, Labrie, Jobin, Arimura & Schally, 1976), thyrotrophin (Vale, Rivier, Brazeau & Guillemin, 1974;Ferland et al, 1976), and prolactin (Vale et al, 1974) release from the pituitary. Also pancreatic insulin and glucagon release (Brown, Rivier & Vale, 1976) and secretion of gastric acid (Lippman & Borella, 1976) are inhibited. Recently it has been reported by Lin, Spray & Tust (1977) that somatostatin has profound effects on bile flow and bile lipid composition in the dog.…”

Section: Introductionmentioning

confidence: 99%

“…In this paper we describe the effect of somatostatin on bile flow, on bile, plasma and liver lipids and on liver glycogen and plasma glucose levels in the rat. Since the inhibition of gastric acid secretions by somatostatin has been demonstrated in the rat (Lippman & Borella, 1976), in other animal species (Barros, Bloom & Baron, 1975;Gomez-Pan, Reed, Albinus, Besser, Coy, Kastin & Schally, 1975) and in man (Raptis, Dollinger, VonBerger, Schlegel, Schroden & Pfeiffer, 1975), we used this criterion to establish the effectiveness of the dose level of somatostatin used in this study.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Somatostatin on Gastric Acid Secretion and on Lipid and Carbohydrate Metabolism in the Rat

Linscheer¹,

Raheja²

1978

British J Pharmacology

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1 Studies were conducted to examine the effects of somatostatin on pentagastrin-induced gastric acid secretion, and on bile, plasma and liver lipid composition in the rat. 2 In addition, liver glycogen and plasma glucose concentrations were measured. 3 Somatostatin was administered intravenously as a bolus (100 jg) at the start of the experiment followed by a continuous infusion (50 gg/h) for 2 h.4 Controls were infused with isotonic saline (1 ml/h) throughout the experiment. Gastric secretions and bile were collected during the infusions. 5 Somatostatin significantly decreased the volume of gastric secretion as well as total gastric acid output but it had no effect on bile flow or bile lipid composition. 6 Plasma and liver lipids were not affected. Plasma glucose concentrations were significantly elevated but liver glycogen was not changed. 7 Our results suggest that somatostatin probably decreases glucose uptake by peripheral tissue. The effect of somatostatin on bile composition and glucose levels in the rat is different from observations reported in other species.

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Inhibition of gastric acid secretion by somatostatin and analogs in the rat

Cited by 19 publications

References 18 publications

Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion

Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion

A Study in Mice of Benzodiazepine-Anticholinergic Interaction: Protection against Restraint-Immersion and Forced Exertion-Induced Gastric Mucosal Erosion

Effects of Somatostatin on Gastric Acid Secretion and on Lipid and Carbohydrate Metabolism in the Rat

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