Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy

Zhang, Nan; Xue, Meilan; Wang, Qing; Liang, Hui; Yang, Jia; Pei, Zhongqian; Qin, Kunpeng

doi:10.1002/ptr.7303

Cited by 18 publications

(12 citation statements)

References 54 publications

(65 reference statements)

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“…It was applied to combined treatments with several anticancer drugs. Taking the example of breast cancer cells, FN combined with cisplatin, tamoxifen, paclitaxel [ 38 ], and doxorubicin [ 23 ] exhibit synergistic antiproliferation effects. Combined treatment of FN with tyrosine kinase inhibitor lapatinib suppresses more proliferation of esophageal cancer cells (OE33) [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Fucoidan/UVC Combined Treatment Exerts Preferential Antiproliferation in Oral Cancer Cells but Not Normal Cells

et al. 2022

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Combined treatment is a promising anticancer strategy for improving antiproliferation compared with a single treatment but is limited by adverse side effects on normal cells. Fucoidan (FN), a brown-algae-derived polysaccharide safe food ingredient, exhibits preferential function for antiproliferation to oral cancer but not normal cells. Utilizing the preferential antiproliferation, the impacts of FN in regulating ultraviolet C (UVC) irradiation were assessed in oral cancer cells. A combined treatment (UVC/FN) reduced cell viability of oral cancer cells (Ca9-22 and CAL 27) more than single treatments (FN or UVC), i.e., 53.7%/54.6% vs. 71.2%/91.6%, and 89.2%/79.4%, respectively, while the cell viability of UVC/FN treating on non-malignant oral (S–G) was higher than oral cancer cells, ranging from 106.0 to 108.5%. Mechanistically, UVC/FN preferentially generated higher subG1 accumulation and apoptosis-related inductions (annexin V, caspases 3, 8, and 9) in oral cancer cells than single treatments. UVC/FN preferentially generated higher oxidative stress than single treatments, as evidenced by flow cytometry-detecting reactive oxygen species, mitochondrial superoxide, and glutathione. Moreover, UVC/FN preferentially caused more DNA damage (γH2AX and 8-hydroxy-2’-deoxyguanosine) in oral cancer cells than in single treatments. N-acetylcysteine pretreatment validated the oxidative stress effects in these UVC/FN-induced changes. Taken together, FN effectively enhances UVC-triggered antiproliferation to oral cancer cells. UVC/FN provides a promising potential for preferential and synergistic antiproliferation in antioral cancer therapy.

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Section: Discussionmentioning

confidence: 99%

“…Recently, the combined treatment of anticancer agents with FN was reported using cisplatin [ 23 ], gefitinib [ 24 ], and vitamin C [ 25 ] for lung, breast, and colon cancer cells, respectively, while the combined treatment of anticancer therapy with FN in oral cancer was rarely applied, particularly together with UVC irradiation.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan/UVC Combined Treatment Exerts Preferential Antiproliferation in Oral Cancer Cells but Not Normal Cells

et al. 2022

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“…Previous experiments have focused on combining fucoidan in a therapeutic system to obtain gatekeeper [ 50 ], target molecule [ 51 ], and anticancer drug [ 52 ] functions, but only for one or two fucoidan functions. In this experiment, we are the first person to integrate all fucoidan functions into one therapeutic system but are still affected by the instability of algal extracts.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan with three functions extracted from Sargassum aquifolium integrated rice-husk synthesis dual-imaging mesoporous silica nanoparticle

Lee

Chen

et al. 2022

J Nanobiotechnol

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In this study, we used the nanoparticle delivery system to reduce the side effect of conventional cancer treatment- radiation therapy and chemotherapy. We used rice husk silicon source mesoporous silica nanoparticle doped in Eu3+ and Gd3+ as the carrier in the delivery system and to enable fluorescence and MRI dual-imaging functions for follow-up therapy. In addition, we choose a popular seaweed extract—fucoidan was extracted from the same brown algae—Sargassum aquifolium collected from Taiwan-Pingtung-Kenting-Chuanfan Rock. In this research, we used acid hydrolysis to prepared two different molecular weight fucoidan, the small molecular fucoidan (Fus) as drug, and the molecular weight approximately 1 kDa fucoidan (Ful) as the nanoparticle gatekeeper, and as targeting molecule for overexpressed P-selectin on the surface of the metastatic tumors. The results of the cell cytotoxicity experiment showed that HCT116 cancer cells have a survival rate of approximately 58.12% when treated with 200 μg/mL fucoidan. Dual-imaging rice husk mesoporous silica nanoparticles (rMSN-EuGd) were modified with 1 kDa fucoidan (Ful) as the gatekeeper and target, and the small molecule fucoidan (Fus) was loaded into nanoparticles (Ful-Fus@rMSN-EuGd) at a concentration of 200 μg/mL. The HCT116 cancer cells had a survival rate of approximately 55.56%. The cell cytotoxicity experiment results show that Ful-Fus@rMSN-EuGd can improve the anticancer effect of fucoidan, and the nanoparticle drug delivery system using fucoidan as a drug, target, and gatekeeper was successfully synthesized.

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“…Zhang et al found that fucoidan induced autophagy in breast cancer cells by down-regulating mTOR/p70S6K/TFEB pathway, thus inhibiting tumor development. At the same time, they also explored the chemotherapeutic sensitization of fucoidan and concluded that fucoidan might enhance the sensitivity of breast cancer cells to chemotherapeutic drugs doxorubicin and cisplatin [125]. These findings will help researchers to further explore the regulatory role of TFEB in cancers as one of the effective targets for anticancer therapy.…”

Section: Promotion Of Autophagy In Anticancer Therapymentioning

confidence: 95%

Research Progress on the Anticancer Molecular Mechanism of Targets Regulating Cell Autophagy

Zhang

Cheng

et al. 2023

Pharmacology

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Background: Autophagy is a lysosome-mediated catabolic process that maintains cell homeostasis and survival. It occurs not only in normal cells such as cardiac muscle cells, neurons, and pancreatic acinar cells but also in various benign and malignant tumors. The abnormal level of intracellular autophagy is closely related to multiple pathophysiological processes, including aging, neurodegeneration, infectious diseases, immune disorders, and cancer. Autophagy mainly plays a dual role in life and death by regulating cell survival, proliferation, and death, thus being involved in the occurrence, development, and treatment of cancer. It is also involved in chemotherapy resistance by a dual role, since it not only promotes the occurrence of drug resistance but also reverses it. Previous findings suggest that the regulation of autophagy can be used as an effective strategy in tumor therapy. Summary: Recent studies found that small molecules from natural products and their derivatives exert anticancer activity by regulating the level of autophagy in tumor cells. Key Messages: Therefore, this review article describes the mechanism of autophagy, the role of autophagy in normal cells and tumor cells, and the research progress on the anticancer molecular mechanism of targets regulating cell autophagy. The aim is to provide a theoretical basis for developing autophagy inhibitors or activators to improve anticancer efficacy.

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Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy

Cited by 18 publications

References 54 publications

Fucoidan/UVC Combined Treatment Exerts Preferential Antiproliferation in Oral Cancer Cells but Not Normal Cells

Fucoidan/UVC Combined Treatment Exerts Preferential Antiproliferation in Oral Cancer Cells but Not Normal Cells

Fucoidan with three functions extracted from Sargassum aquifolium integrated rice-husk synthesis dual-imaging mesoporous silica nanoparticle

Research Progress on the Anticancer Molecular Mechanism of Targets Regulating Cell Autophagy

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